许永性别:
男
职务:
职称:
研究员
学历:
博士通讯地址:
广州市开源大道190号
电话:
邮政编码:
510530
传真:
电子邮件:
xu_yong@gibh.ac.cn
简历：
2011.9–至今研究员，中国科学院广州生物医药与健康研究院。
研究领域：
运用计算生物学、生物化学和结构生物学等方法研究生物大分子的结构与功能以及生物大分子与小分子间的相互作用，在此基础上针对重大疾病相关靶标进行药物设计研究
社会任职：
获奖及荣誉：
代表论著：
1.He,Y.*;Xu,Y.*;Zhang,C.;Gao,X.;Dykema,K.J.;Furge,K.A.;Xu,H.E.Potentiationofglucocorticoidsignalingbychloroquineviainhibitionoflysosomes.ScienceSignaling,2011,Jul5;4(180):ra44.(*co-firstauthor)
2.Martin,K.R.;Xu,Y.;Looyenga,B.D.;Davis,R.J.;Wu,C.L.;Tremblay,M.L.;Xu,H.E.;MacKeigan,J.P.IdentificationofPTPsigmaasanautophagicphosphatase.JCellSci,2011,124,812-819.
3.Zhou,X.E.;Suino-Powell,K.M.;Xu,Y.;Chan,C.W.;Tanabe,O.;Kruse,S.W.;Reynolds,R.;Engel,J.D.;Xu,H.E.TheorphannuclearreceptorTR4isavitaminA-activatednuclearreceptor.JBiolChem,2011,286,2877-2885.
4.Melcher,K.*;Xu,Y*.;Ng,L.M.*;Zhou,X.E.*;Soon,F.F.*;Chinnusamy,V.;Suino-Powell,K.M.;Kovach,A.;Tham,F.S.;Cutler,S.R.;Li,J.;Yong,E.L.;Zhu,J.K.;Xu,H.E.IdentificationandmechanismofABAreceptorantagonism.NatStructMolBiol,2011,17,1102-1108.(*co-firstauthor)
5.Melcher,K.*;Ng,L.M.*;Zhou,X.E.*;Soon,F.F.*;Xu,Y.;Suino-Powell,K.M.;Park,S.Y.;Weiner,J.J.;Fujii,H.;Chinnusamy,V.;Kovach,A.;Li,J.;Wang,Y.;Li,J.;Peterson,F.C.;Jensen,D.R.;Yong,E.L.;Volkman,B.F.;Cutler,S.R.;Zhu,J.K.;Xu,H.E.Agate-latch-lockmechanismforhormonesignallingbyabscisicacidreceptors.Nature,2009,462,602-608.
6.Xu,Y.;Zhang,T.;Chen,M.Combining3D-QSAR,docking,moleculardynamicsandMM/PBSAmethodstopredictbindingmodesfornonsteroidalselectivemodulatortoglucocorticoidreceptor.BioorgMedChemLett,2009,19,393-396.
7.Tao,Y.G.;Xu,Y.;Xu,H.E.;Simons,S.S.,Jr.MutationsofglucocorticoidreceptordifferentiallyaffectAF2domainactivityinasteroid-selectivemannertoalterthepotencyandefficacyofgeneinductionandrepression.Biochemistry,2008,47,7648-7662.
8.Suino-Powell,K.;Xu,Y.;Zhang,C.;Tao,Y.G.;Tolbert,W.D.;Simons,S.S.,Jr.;Xu,H.E.Doublingthesizeoftheglucocorticoidreceptorligandbindingpocketbydeacylcortivazol.MolCellBiol,2008,28,1915-1923.
9.Xu,Y.;Wang,R.AcomputationalanalysisofthebindingaffinitiesofFKBP12inhibitorsusingtheMM-PB/SAmethod.Proteins,2006,64,1058-1068.
10.Xu,Y.;Liu,H.;Niu,C.;Luo,C.;Luo,X.;Shen,J.;Chen,K.;Jiang,H.Moleculardockingand3DQSARstudieson1-amino-2-phenyl-4-(piperidin-1-yl)-butanesbasedonthestructuralmodelingofhumanCCR5receptor.BioorgMedChem,2004,12,6193-6208.
