黎相广 XIANGGUANG LI 副教授
所属学院：生物医药学院
导师类别：硕士生导师
科研方向：干细胞与肠道健康、胃肠道致病微生物检测与治疗
联系方式：**；xgli@gdut.edu.cn
硕士招生学院：生物医药学院
课题组：制药工程系

个人简述：
黎相广，男，博士，副教授，硕士生导师。曾公派到美国俄亥俄州立大学Wexner医学中心访问学习，目前担任广东省生物医学工程学会药品食品智能制造工程分会委员，主要从事干细胞与肠道健康、胃肠道致病微生物检测与治疗的研究工作。主持国家自然科学基金青年基金项目、广东省基础与应用基础研究基金区域联合基金-青年基金项目、广东工业大学“青年****”科研启动项目各1项，发表SCI论文22篇，被引频次超过200次。承担《药理学》、《药物筛选与动物模型》、《药食同源与健康》等课程的教学工作。

学科领域：
科学学位：制药工程
专业学位：材料与化工（生物医药方向）
教育背景：
2016.12–2017.12：美国俄亥俄州立大学Wexner医学中心（访问****）
2014.09–2017.06：华南农业大学动物营养专业（博士）
工作经历：
2021.03–至今：国家自然科学基金委员会，兼聘
2018.01–至今：广东工业大学，生物医药学院，讲师、副教授
2013.07–2014.08：华南农业大学，动物科学学院，科研助理
社会兼职：
广东省生物医学工程学会药品食品智能制造工程分会委员
主要论文
1. Tian-Tian Wang, Xiang-Guang Li*, Li-Li Chen, You-Huan Zhang, Yu-Jun Zheng, Lin-Jin Yu, Zhi-Yu Ye, Hua-Qian Wang, Xi-Ping Cui, Su-Qing Zhao*. The preparation of bifunctional hybrid nano-flowers and their application in the enzyme-linked immunosorbent assay for Helicobacter pylori detection. Analyst. 2021, 146(1):338-347.
2. Xiang-Guang Li, Pan He, Lin-Jin Yu, Qi-Yi He, Cheng-Gang Jia, Hui-Yi Yang, Ming-Lei Lu, Xiu-Ting Wei, Su-Qing Zhao*. Production and characteristics of a novel chicken egg yolk antibody (IgY) against periodontitis-associated pathogens. Journal of Oral Microbiology. 2020, 12(1):**.
3. Hua-Feng He, Dan-Min Lin, Jia-Jie Sun, Xian-Ying He, Tian-Tian Wang, Ying-Lin Fang, Yi-Jun Liu, Kai-Xiang Fan, Xin-Xin Chen, Hua-Hong He, Xiang-Guang Li, Bian-Sheng Ji, Su-Qing Zhao, Xi Zheng, Kun Zhang, Hua-Qian Wang*. An in vitro and in vivo study of the brain-targeting effects of an epidermal growth factor-functionalized cholera toxin-like chimeric protein. Journal of Controlled Release. 2020, 322: 509-518.
4. Jia‐Yi Zhou, Deng‐Gui Huang, Min Zhu, Chun‐Qi Gao, Hui‐Chao Yan, Xiang-Guang Li*, Xiu-Qi Wang*. Wnt/β‐catenin‐mediated heat exposure inhibits intestinal epithelial cell proliferation and stem cell expansion through endoplasmic reticulum stress. Journal of Cellular Physiology. 2020, 235(7-8): 5613-5627.
5. Min Zhu, Ying-Chao Qin, Chun-Qi Gao, Hui-Chao Yan, Xiang-Guang Li*, Xiu-qi Wang*. Extracellular glutamate-induced mTORC1 activation via the IR/IRS/PI3K/Akt pathway enhances the expansion of porcine intestinal stem cells. Journal of Agricultural and Food Chemistry. 2019, 67(34): 9510-9521.
6. Li-Li Chen, Xiang-Guang Li*, Tong-Da Zou, Tian-Tian Wang, Xi-Ping Cui, Ying-Shan Chen, Chun-Guo Zhang, Su-Qing Zhao*. Ultrasensitive detection of H. pylori in human feces based on immunomagnetic bead capture and fluorescent quantum dots. Analyst. 2019, 144(13): 4086-4092.
7. Shao-Jie Liang, Xiang-Guang Li, Xiu-Qi Wang*. Notch signaling in mammalian intestinal stem cells: determining cell fate and maintaining homeostasis. Current Stem Cell Research & Therapy. 2019, 14(7): 583-590.
8. Jia-Yi Zhou, Deng-Gui Huang, Ying-Chao Qin, Xiang-Guang Li, Chun-Qi Gao, Hui-Chao Yan, Xiu-Qi Wang*. mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation. Journal of Cellular Physiology. 2019, 234(10): 19028-19038.
9. Xiang-Guang Li, Min Zhu, Ming-Xia Chen, Hong-Bo Fan, Hou-Long Fu, Jia-Yi Zhou, Zhen-Ya Zhai, Chun-Qi Gao, Hui-Chao Yan, Xiu-Qi Wang*. Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/beta-catenin pathway. Toxicology Letters. 2019, 305: 19-31.
10. Xiang-Guang Li, Zhe Wang, Rong-Qiang Chen, Hou-Long Fu, Chun-Qi Gao, Hui-Chao Yan, Guang-Xu Xing, Xiu-Qi Wang*. LGR5 and BMI1 increase pig intestinal epithelial cell proliferation by stimulating WNT/beta-catenin signaling. International Journal of Molecular Sciences. 2018, 19(4): 1036.
11. Hong-Bo Fan, Zhen-Ya Zhai, Xiang-Guang Li, Chun-Qi Gao, Hui-Chao Yan, Zhe-Sheng Chen, Xiu-Qi Wang*. CDX2 stimulates the proliferation of porcine intestinal epithelial cells by activating the mTORC1 and Wnt/β-catenin signaling pathways. International Journal of Molecular Sciences. 2017, 18(11): 2447.
12. Mi Li #, Haichang Li #, Xiang-Guang Li, Hua Zhu, Zihui Xu, Lianqing Liu*, Jianjie Ma*, Mingjun Zhang*. A bioinspired alginate-gum arabic hydrogel with micro-/nanoscale structures for controlled drug release in chronic wound healing. ACS Applied Materials & Interfaces. 2017, 9 (27): 22160-22175.
13. Jing-E Ma, Qian-Qian Lang, Feng-Fang Qiu, Li Zhang, Xiang-Guang Li, Wen Luo, Juan Wang, Xing Wang, Xi-Ran Lin, Wen-Sheng Liu, Qing-Hua Nie, Xi-Quan Zhang*. Negative glucocorticoid response-like element from the first intron of the chicken growth hormone gene represses gene expression in the rat pituitary tumor cell line. International Journal of Molecular Sciences. 2016, 17(11): E 1863.
14. Jin-Ling Ye #, Chun-Qi Gao #, Xiang-Guang Li #, Cheng-Long Jin, Dan Wang, Gang Shu, Wen-Ce Wang, Xiang-Feng Kong, Kang Yao, Hui-Chao Yan, Xiu-Qi Wang*. EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells. Oncotarget. 2016, 7(25): 38681-38692.
15. Ming-Xia Chen #, Xiang-Guang Li #, Hui-Chao Yan, Xiu-Qi Wang*, Chun-Qi Gao*. Effect of egg weight on composition, embryonic growth, and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (Columba livia). Poultry Science. 2016, 95(6):1425-1432.
16. Xiang-Guang Li, Gao-Feng Xu, Zhen-Ya Zhai, Chun-Qi Gao, Hui-Chao Yan, Qian-Yun Xi, Wu-Tai Guan, Song-Bo Wang, Xiu-Qi Wang*. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget. 2016, 7(21): 30597–30609.
17. Xiang-Guang Li, Wei-Guo Sui, Chun-Qi Gao, Hui-Chao Yan, Yu-Long Yin, Hai-Chang Li, Xiu-Qi Wang*. L-Glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells. Journal of Animal Science. 2016, 94(4):1541-1549.
18. Ming-Xia Chen #, Xiang-Guang Li #, Jun-Xian Yang, Chun-Qi Gao, Bin Wang, Xiu-Qi Wang*, Hui-chao Yan*. The growth of embryo and gene expression of nutrient transporters in the small intestine of domestic pigeon (Columba livia). Journal of Zhejiang University-SCIENCE B. 2015, 16(6): 511-523.
19. Li-Na Wang #, Xue-Ling Chen #, Xiang-Guang Li, Gang Shu, Hui-Chao Yan, Xiu-Qi Wang*. Evaluation of adrenocorticotropin regulated glucocorticoid synthesis pathway in adrenal of different breeds of pigs. Livestock Science. 2014, 169: 185–191.
20. Xiang-Guang Li, Wei-Guo Sui, Hui-Chao Yan, Qing-Yan Jiang, Xiu-Qi Wang*. The in ovo administration of L-trans pyrrolidine-2,4-dicarboxylic acid regulates small intestinal growth in chicks. Animal. 2014, 8(10): 1677-1683.
21. Xiang-Guang Li, Xue-Ling Chen, Xiu-Qi Wang*. Changes in relative organ weights and intestinal transporter gene expression in embryos from White Plymouth Rock and WENS Yellow Feather Chickens. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 2013, 164(2): 368-375.
22. Pei-Ling Zeng #, Xiang-Guang Li #, Xiu-Qi Wang*, De-Xiang Zhang, Gang Shu, Qing-Bin Luo. The relationship between gene expression of cationic and neutral amino acid transporters in the small intestine of chick embryos and chick breed, development, sex, and egg amino acid concentration. Poultry Science. 2011, 90(11): 2548-2556.
科研项目：
1. 国家自然科学基金青年基金项目：石榴皮鞣质调控“肠道干细胞-杯状细胞-MUC2”轴缓解ETEC感染仔猪肠黏膜损伤的机制研究（**），2021/01-2023/12，直接经费24万元，主持
2. 广东省基础与应用基础研究基金区域联合基金-青年基金项目：乳脂肪球膜蛋白质调控肠道干细胞参与ETEC腹泻仔猪肠黏膜修复的机制研究（2019A），2020/01-2022/12，10万元，主持
3. 广东工业大学“青年****”科研启动项目：肠道致病菌卵黄抗体的制备，2018/01-2023/01，10万元，主持
4. 国家自然科学基金面上项目：基于胰岛β细胞保护的中药凉粉草抗糖尿病药效物质及作用机制研究（**），2021/01-2024/12，直接经费55万，参加
5. 广东省重点领域研发计划重大科技专项项目：食源性致病微生物检测新靶标挖掘与检测芯片（2019B），2019/01-2021/12，700万元，参加
6. 广州市科技计划项目：基于甘胆酸、透明质酸和GPC-3的肝脏疾病免疫层析方法研究（4），2019/01-2021/12，100万元，在研，参加
7. 广州市国际合作项目：EAAT3介导谷氨酸转运促进仔猪肠上皮发育的机制（9），2018/04-2020/03，100万元，在研，参加
8. 广东省自然科学基金项目：猪肠道上皮特异转录因子CDX2基因克隆及其对靶基因的调控（2015A），2015/08-2018/08，10万元，已结题，参加
9. 国家自然科学基金重点项目：仔猪小肠上皮隐窝绒毛轴更新与蛋白质代谢的分子机制（**），2014/01-2018/12，287万元，已结题，参加
10. 973项目：“猪利用氮营养素的机制及营养调控”子课题“小肠黏膜结构、功能与氮营养素吸收利用”（2013CB127302），2013/01-2017/12，96万元，已结题，参加