李福男博士、副教授

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个人简历：
李福男博士，药学院副教授。主讲本科生《药学导论》、《药物合成反应》、《药物化学》、《药物化学实验》及研究生《药学研究》等课程。现主要研究方向为创新药物分子的设计、合成及机制研究，药物合成工艺及产业化研究。在Eur J Med Chem等国内外重要学术期刊上发表论文30余篇，出版教材2部，发明专利授权4项（其中国际专利1项）。 荣获厦门大学“我最喜爱的十位老师”、唐立新优秀教学教师奖、厦门大学第四届翻转课堂教学比赛第一名。

教育、工作背景：
1999-2002 延边大学药学院 药物化学硕士（导师：全哲山教授）
2005-2009 韩国首尔大学药学院 药物化学博士（导师：Young-Ger Suh教授、院士）
2010-至今 厦门大学药学院 药物化学与信息学 副教授

主要研究方向：
1、预防和治疗酒精性肝炎、肝纤维化、肝硬化靶点药物的设计、合成及机制研究
2、基于靶点的肺纤维化药物的设计、合成及机制研究
3、抗肿瘤药物的设计、合成及机制研究
4、药物合成工艺及产业化研究

近几年通讯或第一作者论文、专利及著作：
1、Sungwan Ahn, Fu-nan Li*,and Young Taek Han^*. Concise synthesis of nannozinone A, an unusual dihydropyrrolo-pyrazinone metabolite from myxobacteria.Natural Product Communications, 2019, 1-4（*corresponding author)
2、Zhi-Ning Huang, Han Liang, Hong Qiao, Bao-Rui Wang, Ning Qu, Hua Li, Run-Run Zhou, Li-Juan Wang, Shan-Hua Li*, Fu-Nan Li*. Synthesis and structure-activity relationship of N-(piperidin-4-yl)benzamidederivatives as activators of hypoxia-inducible factor 1 pathways. Arch Pharm Res.,2018, 41(12),1149-1161.（*corresponding author)
3、Man-Yi Zheng, Zhi-Ning Huang, Shao-Mei Yang, Han-Liang, Lu-Xu, Bao-Rui Wang, Li-Juan Wang, Hai-Li Wang, Shan-Hua Li, Fu-Nan Li*. Design, synthesis, and structure-activity relationship studies of novel diaryl ether amides as potential antitumor agents. Indian Journal of Chemistry -Section B, 2018, 57, 727-736. （*corresponding author)
4、Shao-Mei Yang, Zhi-Ning Huang, Zhong-Shi Zhou, Jin Hou, Man-Yi Zheng, Li-Juan Wang, Yu Jiang, Xin-Yi Zhou, Qiu-Yue Chen, Shan-Hua Li*, Fu-Nan Li*. Structure-based design, structure-activity relationship analysis, and antitumor activity of diaryl ether derivatives. Arch Pharm Res.,2015, 38(10),1761-1773.（*corresponding author)
5、Jin Hou,Wei Zhao, Zhi-Ning Huang, Shao-Mei Yang, Li-Juan Wang, Yu Jiang, Zhong-Shi Zhou, Man-Yi Zheng, Ji-Li Jiang, Shan-Hua Li*, and Fu-Nan Li*.Evaluation of novel N-(piperidin-4-yl) benzamide derivativesas potential cell cycle inhibitors in HepG2 cells. Chemical Biology & Drug Design, 2015, 86(2):223-231.（*corresponding author)
6、Shi-Ben Wang, Peng Jin, Fu-Nan Li*, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of novel purine derivatives. Eur J Med Chem., 2014, 84,574-583.（*corresponding author)
7、Young Taek Han, Shao-Mei Yang, Xiao-Yuan Wang, and Fu-Nan Li*.Design, Synthesis and Biological Evaluation of B-Region Modified Diarylalkyl Amide Analogues as Novel TRPV1 Antagonists. Arch Pharm Res.,2014, 37 (4) 440-451.（*corresponding author)
8、Nam-Jung Kim*, Fu-Nan Li*, Jin Hee Lee, Seul-gi Park, Kyeojin Kim, Changjin Lim, Young Taek Han, Hwayoung Yun, Jong-Wha Jung, Hyeung-geun Park, Hee-Doo Kim, Byoung Young Woo, Song Seok Shin, Sun-Young Kim, Jin Kyu Choi, Yeon-Su Jeong, Yanghui Park, Young-Ho Park, Dae-Duk Kim, Sun Choi, and Young-Ger Suh. Heterocycle-linked Phenylbenzyl Amides as Novel TRPV1 Antagonists and Their TRPV1 Binding Modes: Constraint-Induced Enhancement of in Vitroand in VivoActivities. Chemistry-an Asian Journal, 2013, 8(2):400-409. (*these authors contributed this work equally)
9、Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Fu-Nan Li*, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 7-Alkoxy-Triazolo-[3, 4-b] Benzo[d]Thiazoles. Medicinal Chemistry, 2010,6(5):313-320. （*corresponding author)
10、Fu-Nan Li, Nam-Jung Kim, Dong-Jo Chang, Jaebong Jang, Hannah Jang, Kyung-Hoon Min, Yeon-Su Jeong, Sun-Young Kim, Young-Ho Park,Hee-Doo Kim, Hyeung-Geun Park, Young-Ger Suh.Synthesis and Structural Optimization of Multiple H-bonding Region of Diarylalkyl (Thio)Amides as NovelTRPV1 Antagonists. Bioorg. Med. Chem., 2009, 17(24), 8149-8160.
11、Fu-Nan Li, Nam-Jung Kim, Yeon-Hee Nam, Seung-Hee Kim,Seung-YongSeo, Yeon-Su Jeong, Sun-Young Kim, Young-Ho Park,and Young-Ger Suh. Design, synthesis, and biological evaluation of phenylpropanamides as novel transient receptor potential vanilloid 1 antagonists. Arch Pharm Res.,2009, 32 (9) 1201-1210.
12、Fu-Nan Li, Nam-Jung Kim, Seung-Mann Paek, Do-Yeon Kwon, Kyung-Hoon Min, Yeon-Su Jeong, Sun-Young Kim, Young-Ho Park,Hee-Doo Kim, Hyeung-Geun Park, and Young-Ger Suh.Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists. Bioorg. Med. Chem., 2009, 17(10), 3557-3567.
13、Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same, 国际专利：WO A3
14、李福男，李善花，朱铉，侯瑾，杨少梅，黄志宁，周仲实. 4-苯氧基苯甲酰胺类化合物及其制备方法和应用。专利号：ZL8.0 申请日：2014.1.7；授权公告日：2016.4.6
15、李福男,李善花,郑满意,梁涵,王宝睿,詹亚东,苗佳颖. 一种类黄酮化合物及其制备方法和应用。专利号：ZL5.2申请日：2017.10.16；授权公告日：2019.05.24
16、李福男,李善花，郑满意，梁涵，王宝睿，乔红，杨国姣. 一种含哌嗪环的类异黄酮化合物及其制备方法和应用。专利号：ZL4.7申请日：2017-10-16；授权公告日：2019.06.14
17、《药物化学》教材，中国医药科技出版社，ISBN号978-7-5067-7907-4，出版时间2016年1 月。
18、《药物化学实验指导》教材，中国医药科技出版社，ISBN号978-7-5067-7928-9，出版时间2016年2 月。

联系方式：
地址：福建省厦门市翔安区翔安南路，厦门大学药学院
Email: fnlee5@xmu.edu.cn