张家兴
职称：教授/博导
学科（专业）：生理学和神经生物学
研究方向：低氧神经生理
电子邮箱：zhangjiaxing@xmu.edu.cn

主要研究领域：
脑是机体利用氧最多和对氧的需求最敏感的器官。我们主要研究低氧及复氧脑的适应与重塑，低氧适应的呼吸和心血管中枢的代偿性调节机制，低氧/复氧对认知功能和情绪影响的神经机制及低氧/复氧基因表达与脑结构和神经细胞活动的关系。我们同时开展人类活体无创研究和动物疾病模型实验，研究手段包括核磁共振、脑电记录、光遗传学技术、分子生物学技术以及认知行为测试。
发表论文：
1、Zhang J*, Chen J, Yu Q, Fan C, Zhang R, Lin J, Yang T, Fan M. Alteration of spontaneous brain activity in COPD patients. International Journal of Chronic Obstructive Pulmonary Disease. 2016:11:1713-1719.
2、Zhao JP, Zhang R, Yu Q, Zhang J*. Characteristics of EEG activity during high altitude hypoxia and lowland reoxygenation. Brain Res. 2016; pii: S0006-8993:30489-9.
3、Chen J, Fan C, Li J, Han Q, Lin J, Yang T, Zhang J*. Increased Intraregional Synchronized Neural Activity in Adult Brain After Prolonged Adaptation to High-Altitude Hypoxia: A Resting-State fMRI Study. High Alt Med Biol. 2016;17:16-24.
4、Chen J, Lin IT, Zhang H, Lin J, Zheng S, Fan M, Zhang J*. Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study. Brain Imaging Behav. 2016;10:464-476.
5、Gan H, Zhang Q, Zhang H, Chen Y, Lin J, Kang T, Zhang J, Troy FA 2nd, Wang B. Development of new population-averaged standard templates for spatial normalization and segmentation of MR images for postnatal piglet brains. Magn Reson Imaging. 2014;32:1396-1402.
6、Zhang J*, Zhang H, Li J, Chen J, Han Q, Lin J, Yang T, Fan M. Adaptive modulation of adult brain gray and white matter to high altitude: structural MRI studies. PLoS One 2013;8:e68621.
7、Zhang J, Zhang H, Chen J, Fan M, Gong Q. Structural modulation of brain development by oxygen: evidence on adolescents migrating from high altitude to sea level environment. PLoS One. 2013;8:e67803.
8、Zhang J*, Yan X, Zhang H, Weng X, Gong Q, Fan M. Adaptive Responses of the Brain to High Altitude. Advances in High-Altitude Medicine and Hypoxic Physiology in China. p18-19. Science (Suppl). 2012; Dec. 17. (http://www.sciencemag.org/site/products/index.xhtml)
9、Zhang H, Wang X, Lin J, Sun Y, Huang Y, Yang T, Zheng S, Fan M, Zhang J*. Reduced Regional Gray Matter Volume in Patients with Chronic Obstructive Pulmonary Disease: A Voxel-Based Morphometry Study. AJNR Am J Neuroradiol. 2013;34:334-339.
10、Zhang H, Wang X, Lin J, Sun Y, Huang Y, Yang T, Zheng S, Fan M, Zhang J*. Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case-control study. BMJ Open. 2012;2:e000844.
11、Zhang H, Lin J, Sun Y, Huang Y, Ye H, Wang X, Yang T, Jiang X, Zhang J*. Compromised white matter microstructural integrity after mountain climbing: evidence from diffusion tensor imaging. High Alt Med Biol. 2012;13:118-125.
12、Yan X, Zhang J*, Gong Q, Weng X. Cerebrovascular reactivity among native-raised high altitude residents: an fMRI study. BMC Neurosci. 2011;12:94.
13、Zhang J*, Liu H, Yan X, Weng X. Minimal Effects on Human Memory Following Long-term Living at Moderate Altitude. High-altitude Medicine and Biology. High Alt Med Biol. 2011;12:37-43.
14、Yan X, Zhang J#*, Gong Q, Weng X. Adaptive influence of long term high altitude residence on spatial working memory: an fMRI study. Brain Cogn. 2011;77:53-59.
15、Yan X, Zhang J#*, Gong Q, Weng X. Appetite at high altitude: an fMRI study on the impact of prolonged high-altitude residence on gustatory neural processing. Exp Brain Res. 2011;209:495-499.
16、Yan X, Zhang J#*, Gong Q, Weng X. Prolonged high-altitude residence impacts verbal working memory: an fMRI study. Exp Brain Res. 2011;208:437-445.
17、Zhang J*, Yan X, Shi J, Gong Q, Weng X, Liu Y. Structural modifications of the brain in acclimatization to high-altitude. PLoS One. 2010;5:e11449.
18、Yan X, Zhang J#*, Shi J, Gong Q, Weng X. Cerebral and functional adaptation with chronic hypoxia exposure: a multi-modal MRI study. Brain Res. 2010;1348:21-29.
19、Zhang J, Lu X, Wang X, Wang L, Du J. Intermittent hypoxia impairs adult mice performance in the two-way shuttle box but not in the Morris water maze. J Neurosci Res. 2006;84:228-235.
20、Zhang J, Chen X, Du J, Chen Q, Zhu C. Neonatal exposure to intermittent hypoxia enhances mice performance in water maze and 8-arm radial maze tasks. J Neurobiol (Dev Neurobiol). 2005;65:72-84.