郑红花 教授/博导
学科（方向）：生物化学/神经科学
所在系部：基础医学部/神经科学研究所
办公电话：
邮 箱：honghua@xmu.edu.cn
课题组网址：http://neuro.xmu.edu.cn/



研究领域：
小胶质细胞（Microglia）是中枢神经系统（Central Nervous System，CNS）内特有的免疫效应细胞，大约占成年脑细胞群的5%～10%，占胶质细胞总数的10%～20%。近年来小胶质细胞上特异性表达的多个基因TREM2，CSF1R等均与神经退行性疾病的发生密切相关，本课题组旨在阐明这些基因在调控小胶质细胞功能中的作用，其异常参与AD等神经退行性疾病发病的分子机制，寻找这类疾病的预防和治疗策略。

学习经历
1993.09~1998.06湖北省咸宁医学院临床医学专业 医学学士；
2002.09~2005.12华中科技大学同济医学院生物化学与分子生物学专业 理学硕士；
2006.09~2009.07华中科技大学同济医学院人体解剖与组织胚胎学专业 医学博士；
2013.09~2014.10美国Mayo Clinic神经科学 博士后

工作经历
1998.09~2009.07历任湖北省咸宁医学院助教、讲师；
2009.08~2012.07厦门大学医学院 助理教授；
2012.08~2020.07厦门大学医学院 副教授；
2020.08~至今 厦门大学医学院 教授

代表性成果
Baoying Cheng, Xin Li, Kai Dai, Shengshun Duan, Zhouyi Rong, Yingmin Chen, Liangcheng Lü, Zhaoji Liu, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang*, Honghua Zheng*. Triggering receptor expressed on myeloid cells-2 (TREM2) interacts with colony-stimulating factor 1 receptor (CSF1R) but is not necessary for CSF1/CSF1R-mediated microglia survival.FrontImmunol. 2021. Accepted.
Rong Z, Cheng B, Zhong L, Ye X, Li X, Jia L, Li Y, Shue F, Wang N, Cheng Y, Huang X, Liu CC, Fryer JD, Wang X, Zhang YW, Zheng H*. Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models. FASEB J.2020;34(8):10984-10997.
Zheng H*, Jia L, Liu CC, Rong Z, Zhong L, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G*. TREM2 promotes microglial survival by activating Wnt/β-catenin pathway. J Neurosci. 2017; 37(7): 1772-1784.
Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G*. Opposing Roles of the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) and TREM-like Transcript 2 (TREML2) in Microglia Activation. Neurobiol Aging.2016; 42:132-141.
Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Xing H, Bu G, Xu H, Zhang YW*, Zheng W*. MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy. Mol Neurobiol.53(1):1-7. 2016.


主持过的重要课题
国家自然科学基金重大研究计划培育项目，NO.**，小胶质细胞介导的天然免疫在脑衰老和神经退行性变中的作用，2020/01-2022/12，在研，主持。
国家自然科学基金面上项目，NO.**，TREM2的功能效应及其突变体参与阿尔茨海默病发生的分子机制研究， 2018/01-2021/12，在研，主持。
国家自然科学基金青年基金项目，NO. **，Menin通过IGFs信号通路调控胚胎神经系统发育的组蛋白甲基化修饰机制，2012/01-2014/12，已结题，主持；
福建省自然科学基金面上项目，NO.2020J01014，TREM2与CSF1R相互作用介导的小胶质细胞存活状态参与AD进程的机制，2020/11-2023/11，在研，主持。
福建省高校青年自然基金重点项目（福建省教育厅科技项目），NO.JZ160403，TREM2调控小胶质细胞迁移和吞噬功能的分子机制， 2017/01-2019/12，已结题，主持。
福建省自然科学基金项目，NO.2016J01411，TREM2介导的小胶质细胞功能异常在AD发病中的作用及机制， 2016/04-2019/04，已结题，主持。
福建省自然科学基金项目，NO.2012J01418，神经管缺陷形成中Men1调控靶基因转录的机制，2012/01-2014/12，已结题，主持。
广东省自然科学基金项目，NO.2017A，TREM2调控阿尔茨海默病（AD）病程中小胶质细胞对淀粉样斑清除功能的分子机制， 2017/05-2020/05，已结题，主持。
广东省自然科学基金项目，NO. 2016A，miRNAs及其靶基因网络调控癫痫神经元异常放电的分子机制， 2016/06-2019/06，已结题，主持。
横向课题（厦门大学附属妇女儿童医院合作课题），NO. XDHT**A，有机酸血症相关性疾病早期快速诊断技术体系研究及其在临床诊疗中的应用，4.5万元，2020/09-2021/03，在研，主持。

已申请的专利
郑红花，郑维红，唐荣，计志林，张云武。microRNA219在制备抗癫痫药物中的应用。专利号ZL2014 1 **.5； 专利授权日期：2016年1月13日。
金光辉，张秀丽，朱铉，刘祖国，郑红花。人纤溶酶原Kringle 5短肽、其药物组合物、用途和编码该短肽的多核苷酸。专利号ZL 5.9；专利授权日期：2014年5月28日

获奖情况
1. 2020年指导本科生参加“第六届全国大学生基础医学创新论坛暨实验设计大赛”获得国家级二等奖；
2. 2018年指导本科生参加“第五届全国大学生基础医学创新论坛暨实验设计大赛”获得国家级一等奖；
3. 微课作品“肥从口入——物质代谢调节与科学合理减肥”获2017年全国高校（医学类）微课教学比赛三等奖；
4. 厦门大学“2018年度本科生科创竞赛优秀指导教师暨德贞社会课堂基金优秀指导教师” ；
5. 2017年至2020年连续四年获评厦门大学医学院大学生创新创业训练计划“优秀指导教师”。

所有论文列表
Baoying Cheng, Xin Li, Kai Dai, Shengshun Duan, Zhouyi Rong, Yingmin Chen, Liangcheng Lü, Zhaoji Liu, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang^?, Honghua Zheng^?. Triggering receptor expressed on myeloid cells-2 (TREM2) interacts with colony-stimulating factor 1 receptor (CSF1R) but is not necessary for CSF1/CSF1R-mediated microglia survival.FrontImmunol. 2021. Accepted.
Yue Wei, Menghui Ma, Sheng Lin, Xin Li, Yue Shu, Ziwei Wang, Yuhang Zhou, Banglian Hu, Baoying Cheng, Shengshun Duan, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang, Honghua Zheng^?.Proteolytic Shedding of Human Colony-Stimulating Factor 1 Receptor and its implication.J CellMolMed.2021. Accepted.
Liu Z, Ning J, Zheng X, Meng J, Han L, Zheng H, Zhong L, Chen XF, Zhang X, Luo H, Can D, Xu H, Zhang YW.TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities.Cell Death Dis. 2020 Aug 13;11(8):678. doi: 10.1038/s41419-020-02874-3.
Rong Z, Cheng B, Zhong L, Ye X, Li X, Jia L, Li Y, Shue F, Wang N, Cheng Y, Huang X, Liu CC, Fryer JD, Wang X, Zhang YW, Zheng H*.Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models.FASEB J2020 Aug;34(8):10984-10997.
Lin JZ, Zheng HH(co-first author), Ma QL, Wang C, Fan LP, Wu HM, Wang DN, Zhang JX, Zhan YH.Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel SPAST Mutation.Front Neurol.2020 May 27;11:399. doi: 10.3389/fneur.2020.00399.
Sun L, Cheng B, Zhou Y, Fan Y, Li W, Qiu Q, Fang Y, Xiao S*, Zheng H*, Li X*.ErbB4 Mutation that Decreased NRG1-ErbB4 Signaling Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.J Alzheimers Dis.2020 Feb 11; 74(2):535-544.
Zhao S, Li Z, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo H, Bu G, Xu H, Yao Y, Zhang YW. A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II. Exp Mol Med. 2019 Jul 23; 51(7):84.
Fu H, Cheng Y, Luo H, Rong Z, Li Y, Lu P, Ye X, Huang W, Qi Z, Li X, Cheng B, Wang X, Yao Y, Zhang YW, Zheng W, Zheng H*.Silencing MicroRNA-155 Attenuates Kainic Acid-Induced Seizure by Inhibiting Microglia Activation.Neuroimmunomodulation. 2019 Mar 29:1-10.
Zheng H* (Correspondence), Cheng B, Li Y, Li X, Chen X, Zhang YW.TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism.Front Aging Neurosci.2018 Nov 23;10:395.
Zhuang K, Huang C, Leng L, Zheng H(co-first author), Gao Y, Chen G, Ji Z, Sun H, Hu Y, Wu D, Shi M, Li H, Zhao Y, Zhang Y, Xue M, Bu G, Huang TY, Xu H, Zhang J*. Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression.2018; Cell reports. 2018 Jul 17;24(3):701-712.
Ye X, Rong Z, Li Y, Wang X, Cheng B, Cheng Y, Luo H, Ti Y, Huang X, Liu Z, Zhang Yw, Zheng W^?, Zheng H^?. Protective role of L-3-n-butylphthalide in cognitive function and dysthymic disorders in mouse with chronic epilepsy. Frontiers in Pharmacology.2018; 9:734.
Pan G,Chen Z,Zheng H,Zhang Yw,Xu H,Bu G, Zheng H, Li Y. Compensatory mechanisms modulate the neuronal excitability in a kainic acid-induced epilepsy mouse model.Frontiers in Neural Circuits. 2018; 12:48.
Sun L, Rong Z, Li W, Zheng H* (Correspondence), Xiao S*, Li X*. Identification of a Novel Hemizygous SQSTM1 Nonsense Mutation in Atypical Behavioral Variant Frontotemporal Dementia.Front Aging Neurosci.2018 Feb 6;10:26. doi: 10.3389/fnagi.2018.00026. eCollection 2018.
Zheng H* (Correspondence), Jia L, Liu CC, Rong Z, Zhong L, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G*. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.J Neurosci. 2017;37(7): 1772-1784.
Li Y, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H. Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease.J Neurosci.2017; 37(38): 9259-9268.
Zhan Y, Zheng H* (Correspondence), Wang C, Rong Z, Xiao N, Ma Q*, Zhang YW*. A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease.Neurobiol Aging. 2017; 50: 168.e1-168.e4.
Zhan L, Yao Y, Fu H, Li Z, Wang F, Zhang X, He W, Zheng W, Zhang Y, Zheng H* (Correspondence). Protective role of miR-23b-3p in kainic acid-induced seizure.Neuroreport.2016; 27(10):764-8.
Wang F, Zheng H（cofirst author）, Zhang X, Li Y, Gao Z, Wang Y, Liu X, Yao Y*. Successful surgery in lesional epilepsy secondary to posterior quandrant ulegyria coexisting with benign childhood focal epilepsy: A case report.Clin Neurol Neurosurg. 2016; 149:94-7.
Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G*. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.Neurobiol Aging. 2016; 42:132-141.
Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G. LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways.J Neuroinflammation. 2016; 13(1):304.
Zhong L, Chen XF, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer JD, Xu H, Bu G. Soluble TREM2 induces inflammatory responses and enhances microglial survival.J Exp Med.2017; 214(3):597-607.
Ye X, Zhang Y, Xu Q, Zheng H, Wu X, Qiu J, Zhang Z, Wang W, Shao Y,Xing HQ. HIV-1 Tat inhibits EAAT-2 through AEG-1 upregulation in models of HIV-associated neurocognitive disorder.2017; 8(24):39922-39934.
Wang J, Zhang Y, Xu Q, Qiu J, Zheng H, Ye X, Xue Y, Yin Y, Zhang Z, Liu Y, Hao Y, Wei Q, Wang W, Mori K, Izumo S, Kubota R, Shao Y, Xing HQ. Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells.Oncotarget. 2017; 8(11):18082-18094.
Fu Y, Zhao J, Atagi Y, Nielsen HM, Liu CC, Zheng H, Shinohara M, Kanekiyo T, Bu G*. Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan.Mol Neurodegener. 2016; 11(1):37.
Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G*. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).J Biol Chem. 2015; 290(43):26043-50.
Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Xing H, Bu G, Xu H, Zhang YW*, Zheng W*. MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy.Mol Neurobiol.53(1):1-7. 2016.
Zheng H, Wang X, Tang Z, Zheng W, Li Z*. The PI3K/Akt and ERK1/2 signaling pathways mediate the erythropoietin-modulated calcium influx in kainic acid-induced epilepsy.Neuroreport.24(6):335-41.2013.
Zhu W, Zheng H（cofirst author）, Shao X, Wang W, Yao Q, Li Z*. Excitotoxicity of TNFalpha derived from KA activated microglia on hippocampal neurons in vitro and in vivo.J Neurochem.114(2):386-96. 2010.
Zheng H, Zhu W, Zhao H, Wang X, Wang W, Li Z*. Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta.Neuroimmunomodulation.17(1):31-38. 2010.
Wang X, Zheng H（cofirst author）, Liu C, Zhu C, Wang W, Li Z*. Ciliary neurotrophic factor-treated astrocyte conditioned medium regulates the L-type calcium channel activity in rat cortical neurons.Neurochem Res.33: 826-832. 2008.
Chen Y, Li D, Liu H, Xu H,Zheng H, Feng Q, Li W, Zhao C, Wang Z, Wang X*. Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells.Cancer Biol Ther.11(1): 14-21. 2011.
Gao SB, Feng ZJ, Xu B, Chen Y, Zheng HH,Yin P, Hua X*, Jin GH*. Meninrepressesmalignantphenotypesofmelanomathroughregulatingmultiplepathways.J Cell Mol Med.15（11）：2353-63. 2011.