陈文生 M.D., Ph.D.
职称：副教授
学科（专业）：眼科学
研究领域：眼表干细胞、免疫及小儿眼科
邮箱：cwensheng@hotmail.com
电话：

教育背景：
1987-1991河南医科大学 临床专业 本科
1998- 2000日本国立秋田大学医学部眼科学讲座研究生
2000-2004 日本国立秋田大学医学部眼科学 博士研究生

工作经历：
1991-1998 河南省南阳市眼科医院从事眼科临床工作
2004日本国立秋田大学眼科学讲座任客座研究员
2004-2007 天津医科大学从事博士后研究工作
2007年 天津医科大学眼科中心任副教授
2008-厦门大学附属厦门眼科中心主任医师 厦门大学眼科研究所副教授

研究方向：眼表干细胞、免疫及小儿眼科

发表论文：

牛贺平 李茗 贾云 胡贤丽 宋长径 刘静 陈文生*泪道激光联合羊膜植入治疗难治性上泪道阻塞.中国实用眼科杂志 2016 34卷 第5期 495-497
刘凡菲 李炜 刘祖国 陈文生*角膜上皮屏障功能的研究进展 中华眼科杂志 2016第52卷 第8期
W Chen*, Liu Z, Tian Q, Niu H, Liu F, Wang X, Xiu Y, N Dong. Levator resection with suspensory ligament of the superior fornix suspension for corretion of pediatric congenital ptosis with poor levator function Eye In press.
Liu Z, Qiu F, Zhu Z, Yang W, Zhou X, An J, Huang F, Wang Q, Reinach PS Li W, Chen Wensheng, Liu Z. Adenomatous polyposis coli mutation leads myopia development in mice. PLoS One. 2015;10:e**.
杨熠生，杨天舒，田青，陈文生黄斑区椭圆体带缺失及恢复 中华眼科杂志 2015；7 (通信作者)
Huang c, Wang H, Pan J, Zhou D, Chen Wensheng, Chen, et al. Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-?1/Smad3 signaling pathway. Invest Ophthalmol Vis Sci. 2014; 55: 8111-8122.
Chen Wensheng, Dong Nuo, Huang Caihong, et al. Corneal alternations induced by topical application of commercial latanoprost, travoprost and bimatoprost in rabbit. PLoS ONE. In press (通信作者)
Chen Wensheng, Zhang Zhenhao, Hu Jiaoyue, et al. Changes in rabbit corneal innervation induced by the topical application of benzalkonium chloride. Cornea. 2013;32:1599-1606 (通信作者).
陈文生， 刘祖国 角膜缘色素痣 中华眼科杂志 2013第十二期
Hu Jiaoyue, Zhang Zhenhao, Xie Hui, Chen Lelei, Zhou Yueping, Chen Wensheng, Liu Zuguo. Serine protease inhibitor A3K protects rabbit corneal endothelium from barrier function disruption induced by TNF-α. Invest Ophthalmol Vis Sci. 2013; 54: 5400-5407 (通信作者).
Chen Wensheng,Hu Jiaoyue, Zhang Zhenhao, et al. Localization and expression of zonula occludins-1 in the rabbit corneal epithelium following exposure to benzalkonium chloride. PLoS ONE. 2012;7(7):e40893 (通信作者).
Chen Wensheng, Li Zhiyuan, Hu Jiaoyue, et al. Corneal alternations induced by topical application of benzalkonium chloride in rabbit. PLoS ONE. 2012;6(10):e26103 (通信作者).
Han Y, Shao Y, Lin Z, Qu YL, Wang H, Zhou Y, Chen W, et al. Netrin-1 simultaneously suppresses corneal inflammation and neovascularization. Invest Ophthalmol Vis Sci. 2012; 53: 1285-1295.
刘祖国，刘靖，陈文生，李炜 眼表上皮疾病的基础与临床研究进展 厦门大学学报（自然科学版）2011；50：489-494
林辉， 刘祖国，李炜， 张梅，刘靖，陈文生等 单纯疱疹病毒性角膜基质炎静止期角膜改变的初步观察 中华眼科杂志 2010；46：785-790
Lin H, Li W, Dong N, Chen W, et al. Changes in corneal epithelial layer inflammatory cells in aqueous tear-deficient dry eye. Invest Ophthalmol Vis Sci. 2010; 51: 122-128.
董诺，李程，李炜，吴护平，陈文生等 Pax6在翼状胬肉上皮鳞状化生中的异常表达 眼科学报 2010；25：44-47
Chen Wensheng, Lin Hui, Dong Nuo et al. Cauterization of central cornea induces recruitment of major histocompatibility complex class II+Langerhans cells from limbal basal epithelium. Cornea. 2010; 29: 73-79 (通信作者).
董诺，陈文生，李炜等 细胞分化及细胞间连接蛋白在睑裂斑上皮细胞的表达 中华生物医学杂志 2009；15：181-184
Chai Y, Shao Y, Lin S, Xiong K, Chen W,et al. Vision-related quality of life and emotional impact in children with strabismus: a prospective study. J Int Med Res. 2009:1108-1114.
陈文生，刘祖国 角膜上皮树突状细胞免疫学研究现状 中华眼科杂志 2009；45：1145-1148
Dong N, Li W, Lin H, Li C, Chen W et al. Abnormal epithelial differentiation and tear film alteration in pinguecula. Invest Ophthalmol Vis Sci. 2009;50:2710-2715.
Chen Wensheng,Hara K, Tian Q, et al. Existence of small slow-cycling Langerhans cells in the limbal basal epithelium that express ABCG2. Exp Eye Res. 2007;84:626-634.Z
Chen Wensheng, Zhao K, Li X, et al. Keratoconjunctivitis sicca modified epithelial stem cell proliferation kinetics in conjunctiva. Cornea. 2007;26:1101-1106.
Chen Wensheng, Cao L, Hara K, et al. Effect of immunosuppression on survival of allograft limbal stem cells. Jpn J Ophthalmol. 2004; 48:440-448 (通信作者)
Chen Wensheng, Ishikawa M, Yamaki K, et al. Wistar rat palpebral conjunctiva contains more slow-cycling stem cells that have larger proliferative capacity: Implication for conjunctival epithelial homeostasis. Jpn J Ophthalmol 2003; 47:119-128(通信作者)