王海龙 副教授/硕导
学科（方向）：生殖生理学
所在系部：基础医学部
办公电话：
邮 箱：hailongwang@xmu.edu.cn



研究领域:
课题组始终围绕人类辅助生殖技术开展系列研究工作，聚焦于卵子发育质量对生育结局的影响，紧密结合临床开展相关课题研究，以实验动物为模型，研究卵母细胞减数分裂和受精的信号转导、不对称分裂纺锤体组装与迁移、染色体分离调节、卵母细胞极性和早期胚胎发育。
本课题组坚持以立德树人为根本，培养具有团队精神的独立科研工作者为己任。研究生进入课题组后，进行生殖医学相关课题研究、发表论文，同时能够掌握临床上的试管婴儿技术，为毕业求职奠定良好的基础；对于想进一步深造的同学来说，我们的受精机制研究是医学与生命科学的开始，理解医学与生命的本质，可为以后深入基础研究打开科学梦想之门。

学习经历：
1996-2000 东北农业大学 动物科学专业 学士；
2000-2003东北农业大学 动物遗传育种与繁殖专业 硕士； 2003-2007 中科院动物所与东北农业大学联培 动物胚胎学 博士。

工作经历：
2007-2013 厦门大学医学院 讲师；
2013-2014 美国西奈山医学院，访问****；
2013-至今厦门大学医学院 副教授；

主持过的重要课题：
国家重点研发计划项目（2017YFD**）：母畜繁殖调控新兽药研发，2017/07-2020/12
国家自然科学基金面上项目（**）：TACC3调节小鼠卵母细胞减数分裂的机制，2017/01-2020/12
国家自然科学基金青年项目（**）：糖尿病影响小鼠卵母细胞组蛋白乙酰化的机制，2013/01-2015/12

期刊论文：
He S, Xu B, Liu Y, Wang Y, Chen M, Xu L, Liao B, Lui R, Li F, Lin Y, Fu X, Fu B, Hong Z, Liu Y, Qi ZQ*, Wang H*.SKAP2 regulates Arp2/3 complex for actin-mediated asymmetric cytokinesis by interacting with WAVE2 inmouseoocytes. Cell Cycle.2017 Sep 21:1-10. doi: 10.1080/**. 2017. **. (Corresponding author) *
Liu Y, Wang Y, He S, Chen M, Zhang Z, Fu X, Fu B, Liao B, Lin Y, Qi Z*, Wang H*. Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes.Oncotarget.2017 Jan 24; 8(4):6233-6245. doi: 10.18632/oncotarget.14056. (Corresponding author) *
Chen M, Liu Y, Wang Y, Liu R, Xu B, Zhang F, Li F, Xu L, Lin Y, He S, Liao B, Fu X, Wang X, Yang X*, Wang H*. KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte. Sci Rep.2016 Dec 19;6:39337. doi: 10.1038/srep39337 (Corresponding author) *
Liu Y, Xu B, Liu R, Xu L, Zhang F, Li F, Zhang Z, Wang Y, Chen M, Qi Z*, Wang H*, Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation, Mol Reprod Dev.2016 Jul 19. doi: 10.1002/mrd.22683. (Corresponding author) *
He X,Song Y,Liu R,Liu Y,Zhang F,Zhang Z,Shen Y,Xu L,Chen M,Wang Y,Xu B,Yang X*,Wang H*, Axin-1 Regulates Meiotic Spindle Organization inMouseOocytes. PloS One.2016 Jun 10;11(6):e**. (Corresponding author) *
Shen Y, Song Y, He X, Zhang F, Huang X, Liu Y, Ding L, Xu L, Zhu M, Hu W, Qi Z, Wang H*,Yang X*, Triphenyltin chloride induces spindle microtubule deploy-merization and inhibits meiotic maturation in mouse oocytes, Reprod Fertil Dev.2014 Oct;26(8):1084-93. (Corresponding author) *
Huang X, Ding L, Pan R, Ma P, Cheng P, Zhang C, Sheng Y, He X, Qi Z*, Wang H*,WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes. Histochem Cell Biol.2013 Apr;139(4):525-34 (Corresponding author) *
Liu Y, Huang X, He X, Ding L, Xu L, Shen Y, Zhang F, Zhu M, Qi Z*, Wang H*, Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage, PloS One.2013 Oct 23;8(10):e77960 (Corresponding author) *
Ding L, Pan R, Huang X, Wang J, Shen Y, Xu L, Zhang Y, Liu Y, He X, Yang X, Qi Z*, Wang H*,Changes in histone acetylation during oocyte meiotic maturation in diabetic mouse. Theriogenology. 2012 Sep;78(4):784-92. (Corresponding author) *
Huang X,Tong J,Wang Z,Yang C,Qi S,Guo L,Ouyang Y,Quan S,Sun Q, Qi Z, Huang R*, Wang H*, JNK2 participates in spindle assembly during mouse oocyte meiotic maturation. Microsc Microanal. 2011Apr;17(2):197-205. (Corresponding author) *
Huang X^#,Wang H^#,Qi S,Wang Z,Tong J,Zhang Q,Ouyang Y,Hou Y,Schatten H.,Qi Z,Sun Q. DYNLT3 is required for chromosome alignment during mouse oocyte meiotic maturation. Reprod Sci.2011 Oct; 18(10): 983-9. (Co-first author)^#
Lan T,Wang L,Xu L,Jin N,Yan G,Xia J,Wang H*,Zhuang G,Gao C,Meng L,Du F,Zhou Q,Qi Z, Induced Pluripotent Stem Cells Can Effectively Differentiate into Multiple Functional Lymphocyte Lineages In Vivo with Negligible Bias. Stem Cells Dev.2016 Mar 15;25(6):462-71.
Ding J, Huang X, Shao N, Zhou H, Lee DF, Faiola F, Fidalgo M, Guallar D, Saunders A, Shliaha PV, Wang H*, Waghray A, Papatsenko D, Sánchez-Priego C, Li D, Yuan Y, Lemischka IR, Shen L, Kelley K, Deng H, Shen X, Wang J. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Cell Stem Cell.2015 Jun 4;16(6):653-68.
Cheng P,Xia J,Wang H*,Chen J,Wang F,Zhang Y,Huang X,Zhang Q, Qi Z. Islet transplantation reverses the effects of maternal diabetes on mouse oocytes. Reproduction.2011 Apr;141(4):417-24.