任 杰副教授/硕导
学科（方向）：基础医学
所在系部：厦门大学基础医学部
邮 箱：renjie_7912@xmu.edu.cn



学习经历：
1997~2001 吉林大学/沈阳药科大学（联合培养）生物制药系 学士；
2001~2006 沈阳药科大学生物制药系 博士；
2003~2003 韩国釜山大学 生物化学专业 交流学习。
工作经历：
2005~2015 厦门大学医学院，讲师；
2015~至今厦门大学医学院，副教授；
2008~2008 美国加州大学尔湾分校，药理学系，访问****。
代表性成果：
1. Yan Qiu?,Jie Ren?,Hongwei Ke,Yang Zhang,Qi Gao,Longhe Yang,Canzhong Lu*andYuhang Li*, Design and synthesis of uracil urea derivatives as potent and selective fatty acid amide hydrolase inhibitors, RSC Advances, 2017,7, 22699-22705;
2. Jie Ren, Yuhang Li*, Hongwei Ke, Yanting Li, Longhe Yang, Helin Yu, Rui Huang, Canzhong Lu, and Yan Qiu*, Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potentN-acylethanolamine acid amidase (NAAA) inhibitors, RSC Advances, 2017,7, 12455-12463;
3. Yuhang Li,Qi Chen,Longhe Yang,Yanting Li,Yang Zhang,Yan Qiu*,Jie Ren, Canzhong Lu*, Identification of highly potentN-acylethanolamine acid amidase (NAAA) inhibitors: Optimization of the terminal phenyl moiety of oxazolidone derivatives, European Journal of Medicinal Chemistry, 2017, 139, 214-221;
4. Ling Chen, Jie Ren, Longhe Yang, Yanting Li, Jin Fu, Yuhang Li, Yifeng Tian, Funan Qiu, Zuguo Liu*, Yan Qiu*, Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis, Scientific Reports, 2016, 6, 19665; doi: 10.1038/srep19665;
5. Yan Qiu*, Yang Zhang, Yuhang Li, Jie Ren, Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase, Molecules, 2016, 21, 229; doi:10.3390/molecules**;
6.Ling Chen, Huixia Chen, Yanting Li, Lei Li, Yan Qiu and Jie Ren*, Endocannabinoid and ceramide levels are altered in patients with colorectal cancer, Oncology Reports, 2015, 34, 447-454
7. Long Li, Lei Li, Ling Chen, Xiaoyu Lin, Yaping Xu, Jie Ren, Jin Fu, Yan Qiu*, Effect of Oleoylethanolamide on Diet-induced Nonalcoholic Fatty Liver in Rats, Journal of Pharmacological Sciences, 2015, 127, 244-250;
8.Ling Chen#, Long Li#, Junde Chen, Lei Li, Zihan Zheng, Jie Ren, Yan Qiu*, Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells, Oncotarget, 2015, 6 (40), 42530-42540
9.Angran Fan#, Xiaofeng Wu#, Huijuan Wu, Long Li, Rui Huang, Yueyong Zhu, Yan Qiu, Jin Fu,Jie Ren*, Chenggang Zhu*, Atheroprotective Effect of Oleoylethanolamide (OEA) Targeting Oxidized LDL, Plos One, 2014, 9 (1), e85337
10. Longhe Yang, Yanting Li, Jie Ren,Chenggang Zhu, Jin Fu, Donghai Lin*, Yan Qiu*, Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2, International Journal of Molecular Sciences, 2014, 15, 13637-13648；
11.Xiyue Wu#, Lijun Han#, Xiaolin Zhang, Long Li, Changzhen Jiang, Yan Qiu, Rui Huang, Baoying Xie, ZhiXiong Lin, Jie Ren*, Jin Fu*, Alteration of endocannabinoid system in human gliomas, Journal of Neurochemistry, 2012，120 (5), 842-849
主持过的重要课题：
1. 抑制SCD1促进神经酰胺聚集诱导肿瘤细胞凋亡的作用及机制，17.3万元，国家自然科学基金项目（**），2017.1-2019.12；主持
2. SCD1调控神经酰胺表达在肠癌发生发展中的作用及机制研究，4万，福建省自然科学基金（2017J01146），2017.04-2020.04，主持
3. 内源性大麻素系统调控脑胶质瘤干细胞机制的研究，3万元，福建省自然科学基金（2013J05122），2013.01-2015.12，主持
所有论文列表：
https://www.ncbi.nlm.nih.gov/pubmed/?term=xiamen+University+Jie+Ren