李善花 副教授/硕导
学科（方向）：人体解剖与组织胚胎学/低氧应激的表观遗传学
所在系部：基础医学部
办公电话：
邮 箱：lish@xmu.edu.cn





研究领域：
从事人体解剖与组织胚胎学的教学工作，主要研究方向为低氧应激的表观遗传学，主持并参与多项国家级、省级自然科学基金的研究。对低氧诱导因子转录的调控及小分子药物活性筛选进行了较深入的研究，HIF信号通路是细胞内缺氧应激最重要的信号通路之一，它在许多生物学反应包括细胞周期调控、细胞增殖、发育、分化、衰老、凋亡、代谢、免疫反应及肿瘤发生中起重要作用。熟练掌握多种原代细胞分离培养技术以及形态学、分子生物学和生物化学等多学科的研究手段，在PNAS等SCI收录刊物上发表多篇研究论文。
学习经历：
1991～1996 延边大学医学院临床医学专业 医学学士
1996～1999 延边大学医学院人体解剖与组织胚胎学专业医学硕士
2006～2010 韩国首尔大学医科大学药理学专业 医学博士
工作经历：
1999～2011 延边大学医学院 助教、助理教授；
2010～2011 韩国首尔大学医科大学 博士后；
2011～至今厦门大学医学院 副教授。
代表性成果：

Shin DH, Li SH*, Chun YS, Huang LE, Kim MS, Park JW. CITED2 mediates the paradoxical responses of HIF-1 alpha to proteasome inhibition. Oncogene. 2008, 27(13):1939-1944.
Li SH*, Shin DH, Chun YS, Lee MK, Kim MS, Park JW. A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}. Mol Cancer Ther. 2008, 7(12):3729-3738.
Ryu JH, Li SH*, Park HS, Park JW, Lee B, Chun YS. NEDD8 conjugation stabilizes HIF-alpha subunits reactive oxygen species-dependently. J Biol Chem. 2011, 286 (9): 6963-70.
Li SH*,Chun YS, Lim JH, Huang LE, Park JW. von Hippel-Lindau Protein Adjusts Oxygen Sensing of the FIH Asparaginyl Hydroxylase. Int J Biochem Cell Biol. 2011, 43: 795-804.
Xu B, Li SH*, Zheng R, Gao SB, Ding LH, Yin ZY, Lin X, Feng ZJ, Zhang S, Wang XM, Jin GH. Menin promotes hepatocelluar carcinogensis and epigenetically up-regulates Yap1 transcription. Proc Natl Acad Sci U S A. 2013, 110(43):17480-5.
Jin Hou,Wei Zhao, Zhi-Ning Huang, Shao-Mei Yang, Li-Juan Wang, Yu Jiang, Zhong-Shi Zhou, Man-Yi Zheng, Ji-Li Jiang, Shan-Hua Li^#, and Fu-Nan Li.Evaluation of novel N-(piperidin-4-yl) benzamide derivativesas potential cell cycle inhibitors in HepG2 cells. Chemical Biology & Drug Design, 2015, 86:223-231.
主持过的重要课题：
国家自然科学基金，FIH氧依赖调节低氧诱导因子转录活性分子作自用机制及其对肾细胞癌靶向治疗的实验研究，2012.01-2014.12
国家自然科学基金，MLL促进肝癌的靶基因鉴定及其表观遗传学特性的研究，2015.01-2018. 12
已申请的专利：
4-苯氧基苯甲酰胺类化合物及其制备方法和应用，专利号：ZL 2014 1 **.0
所有论文列表：
1.Structure-based design, structure-activity relationship analysis, and antitumor activity of diaryl ether derivatives.
Yang SM, Huang ZN, Zhou ZS, Hou J, Zheng MY, Wang LJ, Jiang Y, Zhou XY, Chen QY, Li SH, Li FN.Arch Pharm Res. 2015 Oct;38(10):1761-73. PMID:**
2. Evaluation of Novel N-(piperidine-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 Cells.
Hou J, Zhao W, Huang ZN, Yang SM, Wang LJ, Jiang Y, Zhou ZS, Zheng MY, Jiang JL, Li SH, Li FN.Chem Biol Drug Des. 2015 Aug;86(2):223-31. PMID:**
3. The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma.
Gao SB, Xu B, Ding LH, Zheng QL, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH.J Hepatol. 2014 Oct;61(4):832-9.PMID:**
4. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
Xu B, Li SH, Zheng R, Gao SB, Ding LH, Yin ZY, Lin X, Feng ZJ, Zhang S, Wang XM, Jin GH.Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17480-5. PMID:**
5. Interplay between menin and K-Ras in regulating lung adenocarcinoma.
Wu Y, Feng ZJ, Gao SB, Matkar S, Xu B, Duan HB, Lin X, Li SH, Hua X, Jin GH.J Biol Chem. 2012 Nov 16;287(47):40003-11.PMID:**
6. PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer.
Lee KH, Park JW, Sung HS, Choi YJ, Kim WH, Lee HS, Chung HJ, Shin HW, Cho CH, Kim TY, Li SH, Youn HD, Kim SJ, Chun YS.Oncogene. 2015 May 28;34(22):2897-909. PMID:**
7. Red ginseng and 20(S)-Rg3 control testosterone-induced prostate hyperplasia by deregulating androgen receptor signaling.
Bae JS, Park HS, Park JW, Li SH, Chun YS.J Nat Med. 2012 Jul;66(3):476-85.PMID:**
8. von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase.
Li SH, Chun YS, Lim JH, Huang LE, Park JW.Int J Biochem Cell Biol. 2011 May;43(5):795-804. PMID:**
9. Hypoxia-inducible factor α subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent.
Ryu JH, Li SH, Park HS, Park JW, Lee B, Chun YS.J Biol Chem. 2011 Mar 4;286(9):6963-70. PMID:**
10. Survivin mediates prostate cell protection by HIF-1alpha against zinc toxicity.
Yun YJ, Li SH, Cho YS, Park JW, Chun YS.Prostate. 2010 Aug;70(11):1179-88. PMID:**
11. Vitamin C supplementation prevents testosterone-induced hyperplasia of rat prostate by down-regulating HIF-1alpha.
Li SH, Ryu JH, Park SE, Cho YS, Park JW, Lee WJ, Chun YS.J Nutr Biochem. 2010 Sep;21(9):801-8. PMID:**
12.Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha.
Shin DH, Li SH, Yang SW, Lee BL, Lee MK, Park JW.FEBS J. 2009 Jul;276(13):3470-80. PMID:**
13. A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.
Li SH, Shin DH, Chun YS, Lee MK, Kim MS, Park JW.Mol Cancer Ther. 2008 Dec;7(12):3729-38. PMID:**
14. Cloning of miniature pig HIF-1alpha and its responses to immunosuppressive agents.
Kim KE, Jung YJ, Li SH, Chun YS, Ahn C, Park JW.Immunopharmacol Immunotoxicol. 2008;30(1):105-15. PMID:**
15. CITED2 mediates the paradoxical responses of HIF-1alpha to proteasome inhibition.
Shin DH,Li SH, Chun YS, Huang LE, Kim MS, Park JW.Oncogene. 2008 Mar 20;27(13):1939-44. PMID:**