毛宇彬 副教授
学科（方向）：病理生理学/肿瘤病理
所在系部：基础医学部
邮 箱：maoyubin@xmu.edu.cn


研究领域：
研究领域为肿瘤病理学，主要研究实体瘤发生的病理机制及分子病理诊断研究。
学习经历
1988~1993 西安医科大学临床医学专业 医学学士
1995~1998 西安医科大学病理生理学专业 医学硕士
2004~2007 厦门大学肿瘤生物学专业 理学博士
工作经历：
1993~1998 西安交通大学医学院 助教
1998~2002 厦门市中医院 主治医师
2002~2008 厦门大学医学院 助理教授
2008~至今 厦门大学医学院副教授
代表性成果：
MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2.an C, Lin Y, Mao Y, Huang Z, Liu AY, Ma H, Yu D, Maitikabili A, Xiao H, Zhang C, Liu F, Luo Q, Ouyang G. Oncotarget. 2016 Mar 8.doi:10.18632/oncotarget.7989.
Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis.Wang Z,Xiong S, Mao Y,Chen M,Ma X,Zhou X,Ma Z,Liu F,Huang Z,Luo Q,Ouyang G. J Pathol.2016 Aug;239(4):484-95. doi: 10.1002/path.4747. Epub 2016 Jul 8.
Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma.Wang W, Zhong W, Yuan J, Yan C, Hu S, Tong Y, Mao Y, Hu T, Zhang B, Song G.Oncotarget. 2015 Dec 8;6(39):42276-89. doi: 10.18632/oncotarget.5514.
Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24.Liu AY, Cai Y, Mao Y, Lin Y, Zheng H, Wu T, Huang Y, Fang X, Lin S, Feng Q, Huang Z, Yang T, Luo Q, Ouyang G. Carcinogenesis.2014Mar;35(3):537-45.
The Role of Nuclear β-Catenin Accumulation in the Twist2-Induced Ovarian Cancer EMT.Mao Y, Xu J, Li Z, Zhang N, Yin H, Liu Z. PLoS One. 2013 Nov 11;8(11):e78200.
Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24.Liu AY, Cai Y, Mao Y,Lin Y, Zheng H, Wu T, Huang Y, Fang X, Lin S, Feng Q, Huang Z, Yang T, Luo Q, Ouyang G. Carcinogenesis. 2013 Nov 30.
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth.Cheng L, Huang Z, Zhou W, Wu Q, Donnola S, Liu JK, Fang X, Sloan AE, Mao Y, Lathia JD, Min W, McLendon RE, Rich JN, Bao S. Cell. 2013 Mar 28;153(1):139-52. doi: 10.1016/j.cell.2013.02.021
iTRAQ Based Quantitative Proteomics Approach Validated the Role of Calcyclin Binding Protein (CacyBP) in Promoting Colorectal Cancer Metastasis.Ghosh D, Li Z, Tan XF, Lim TK, Mao Y, Lin Q. Mol Cell Proteomics. 2013 Jul;12(7):1865-80. doi: 10.1074/mcp.M112.023085. Epub 2013 Mar 29.
Significance of heterogeneous Twist2 expression in human breast cancers.Mao Y, Zhang N, Xu J, Ding Z, Zong R, et al. (2012) PLoS One 7:e48178.
主持过的重要课题：
国家自然科学基金面上项目，转录因子Dermo1经EMT介导促进乳腺癌细胞表型转变的可能性研究，No.**，200901-201112。
福建省自然科学基金面上项目，Twist2诱导卵巢癌EMT的网络分子研究，No.2012J01417，201201-201312。
所有论文链接：
Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis.Wang Z, Xiong S, Mao Y, Chen M, Ma X, Zhou X, Ma Z, Liu F, Huang Z, Luo Q, Ouyang G.J Pathol. 2016 Aug;239(4):484-95. doi: 10.1002/path.4747. Epub 2016 Jul 8.
MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2.Fan C, Lin Y, Mao Y, Huang Z, Liu AY, Ma H, Yu D, Maitikabili A, Xiao H, Zhang C, Liu F, Luo Q, Ouyang G. Oncotarget. 2016 Apr 19;7(16):21825-39. doi: 10.18632/oncotarget.7989.
Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma.Wang W, Zhong W, Yuan J, Yan C, Hu S, Tong Y, Mao Y, Hu T, Zhang B, Song G. Oncotarget. 2015 Dec 8;6(39):42276-89. doi:10.18632/oncotarget. 5514.
The role of nuclear β-catenin accumulation in the Twist2-induced ovarian cancer EMT.Mao Y, Xu J, Li Z, Zhang N, Yin H, Liu Z.PLoS One. 2013 Nov 11;8(11):e78200. doi: 10.1371/journal.pone.**. eCollection 2013.
Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24.Liu AY, Cai Y, Mao Y, Lin Y, Zheng H, Wu T, Huang Y, Fang X, Lin S, Feng Q, Huang Z, Yang T, Luo Q, Ouyang G.Carcinogenesis. 2014 Mar;35(3):537-45. doi: 10.1093/carcin/bgt364. Epub 2013 Nov 5.
Twist2 promotes ovarian cancer cell survival through activation of Akt.Mao Y, Xu J, Song G, Zhang N, Yin H.Oncol Lett. 2013 Jul;6(1):169-174. Epub 2013 Apr 24.
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth.Cheng L, Huang Z, Zhou W, Wu Q, Donnola S, Liu JK, Fang X, Sloan AE, Mao Y, Lathia JD, Min W, McLendon RE, Rich JN, Bao S. Cell. 2013 Mar 28;153(1):139-52. doi: 10.1016/j.cell.2013.02.021
iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis..Ghosh D, Li Z, Tan XF, Lim TK, Mao Y, Lin Q. Mol Cell Proteomics. 2013 Jul;12(7):1865-80. doi: 10.1074/mcp.M112.023085. Epub 2013 Mar 29.
Significance of heterogeneous Twist2 expression in human breast cancers.Mao Y, Zhang N, Xu J, Ding Z, Zong R, et al. (2012) PLoS One 7:e48178.
Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.Xia W, Liu Z, Zong R, Liu L, Zhao S, Bacus SS, Mao Y, He J, Wulfkuhle JD, Petricoin EF 3rd, Osada T, Yang XY, Hartman ZC, Clay TM, Blackwell KL, Lyerly HK, Spector NL. Mol Cancer Ther. 2011 Aug;10(8):1367-74. doi: 10.1158/1535-7163.MCT-10-0991. Epub 2011 Jun 14.
Differential methylation of CpG islands within the dermo1 gene promoter in several cancer cell lines.Mao Y, Toh HB, Ding Z, Sun L, Hong L, Chen CS, Wu X. Oncol Rep. 2011 Jan;25(1):107-11.
D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.Liu M, Li C, Pazgier M, Li C, Mao Y, Lv Y, Gu B, Wei G, Yuan W, Zhan C, Lu WY, Lu W. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14321-6. doi: 10.1073/pnas.. Epub 2010 Jul 26.
Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways.Ouyang G, Yao L, Ruan K, Song G, Mao Y, Bao S. Cell Biol Int. 2009 Dec;33(12):1237-44. doi: 10.1016/j.cellbi.2009.08.011. Epub 2009 Sep 2.
Osteopontin promotes gastric cancer metastasis by augmenting cell survival and invasion through Akt-mediated HIF-1alpha up-regulation and MMP9 activation.Song G, Ouyang G, Mao Y, Ming Y, Bao S, Hu T.J Cell Mol Med. 2009 Aug;13(8B):1706-18. doi: 10.1111/j.1582-4934.2008.00540.x.
Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway.Ouyang G, Liu M, Ruan K, Song G, Mao Y, Bao S.Cancer Lett. 2009 Aug 28;281(2):213-9. doi: 10.1016/j.canlet.2009.02.030. Epub 2009 Mar 27.
Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells.Song G, Ming Y, Mao Y, Bao S, Ouyang G. Exp Biol Med (Maywood). 2008 Dec;233(12):1537-45. doi: 10.3181/0805-RM-164. Epub 2008 Oct 10.
ATPase domain of Hsp70 exhibits intrinsic ATP-ADP exchange activity.Mao Y, Deng A, Qu N, Wu X. Biochemistry (Mosc). 2006 Nov;71(11):1222-9.
Hydrogen peroxide-induced apoptosis in human gastric carcinoma MGC803 cells.Mao Y, Song G, Cai Q, Liu M, Luo H, Shi M, Ouyang G, Bao S. Cell Biol Int. 2006 Apr;30(4):332-7. Epub 2006 Mar 13.
Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells.Shi M, Cai Q, Yao L, Mao Y, Ming Y, Ouyang G. Cell Biol Int. 2006 Mar;30(3):221-6. Epub 2005 Dec 22.