何承勇
厦门大学理学博士学位
厦门大学生命科学学院副教授、硕士生导师
Email：hecy@xmu.edu.cn
学术简历：
2003/09-2007/06，南京农业大学，无锡渔业学院，本科
2007/09–2009/09，厦门大学，生命科学学院，硕士研究生
2011/09–2012/08, Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, USA国家留学基金委公派联合培养博士
2009/09–2012/12，厦门大学，生命科学学院生物学系，博士
2013/01–2017/07，厦门大学，公共卫生学院预防医学系，助理教授
2017/08–2018/07，厦门大学，公共卫生学院预防医学系，副教授
2018/08–至今，厦门大学，生命科学学院生物学系，副教授


研究方向：纳米毒理学、环境毒理学
主持和参与科研课题：
1. 国家自然科学基金面上项目，**，Kyn/AhR通路调控T细胞活化促进黑磷量子点诱导肾脏损伤的分子机制，2021/01-2024/12，在研，主持
2. 国家自然科学基金青年项目，**，多环芳烃通过NO介导的亚硝基化影响海马神经发育的机制研究，2015/01-2017/12，已结题，主持
3. 厦门大学校长基金，，未折叠蛋白反应ATF4通路调控内质网自噬介导量子点肾损伤机制研究与应用，2018/1-2020/12，在研，主持
4. 国家重点研究计划，“肝癌高特异性近红外纳米成像探针的设计与合成”，2017-2020，在研，参加



代表性论文：

1. Chengyong He^#*, Fengkai Ruan^#, Shengwei Jiang^#, Jie Zeng, Hanying Yin, Rong Liu, Yongxing Zhang, Laiqiang Huang, Chonggang Wang, Shaohua Ma*, Zhenghong Zuo*. Black Phosphorus Quantum Dots Cause Nephrotoxicity in Organoids, Mice and Human Cells. Small. 2020, ** (IF=11.4, JCR1区).
2. Chengyong He^#, Shengwei Jiang^#, Haijing Jin^#, Shuzhen Chen, Gan Lin, Huan Yao, Xiaoyong Wang, Peng Mi, Zhiliang Ji, Yuchun Lin*, Zhongning Lin*, Gang Liu*. Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity. Biomaterials. 2016;83:102-114. (IF=10.3, JCR1区)
3.Fengkai Ruan, Rong Liu, Jie Zeng, Kai Wang, Zhenghong Zuo, Chengyong He*, Yongxing Zhang*, Cytotoxicity of black phosphorus quantum dots on lung-derived cells and the underlying mechanisms. Journal of Hazardous Materials. jhazmat.2020.122875 (IF=9.03, JCR1区)
4.Shengwei Jiang^#, Yuchun Lin^#, Huan Yao^#, Chuanli Yang, Liyin Zhang, Bing Luo, Zhao Lei, Liwei Cao, Naibo Lin, Xiangyang Liu*, Zhongning Lin*, Chengyong He*. The role of unfolded protein response and ER-phagy in quantum dots-induced nephrotoxicity: an in vitro and in vivo study. Archives of Toxicology. 2018;92(541) 1-14. (IF=5.05, JCR1区)
5.Chengyong He^#, Shengwei Jiang^#, Huan Yao^#, Liyin Zhang, Chuanli Yang, Denglin Zhan, Gan Lin, Yun Zeng, Yankai Xia, Zhongning Lin*, Gang Liu*, Yuchun Lin*. Endoplasmic reticulum stress mediates inflammatory response triggered by ultra-small superparamagnetic iron oxide nanoparticles in hepatocytes. Nanotoxicology. 2018;12(10): 1198-1214. (IF=4.92, JCR1区)
6.Chengyong He^#, Shengwei Jiang^#, Huan Yao^#, Liyin Zhang, Chuanli Yang, Shan Jiang, Fengkai Ruan, Denglin Zhan, Gang Liu, Zhongning Lin*, Yuchun Lin*, Xiaoyuan Chen. High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment. Nanomedicine-Nanotechnology Biology and Medicine. 2019 Jan;15(1):59-69. (IF=5.18, JCR1区)
7.Mei Chen^#, Shuzhen Chen^#, Chengyong He^#, Shiguang Mo, Xiaoyong Wang, Gang Liu*, and Nanfeng Zheng*, Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging. Nano Research. 2017;10(4): 1234–1248. (IF=8.18, JCR1区)
8.Chengyong He^#, Yang Qiu^#, Peiyu Han^#, Yuanyuan Chen, Liyin Zhang, Quan Yuan, Tianying Zhang, Tong Cheng, Lunzhi Yuan, Chenghao Huang, Sheng Zhang, Zhenyu Yin, Xian-E Peng, Dong Liang, Xu Lin, Yuchun Lin*, Zhongning Lin*, and Ningshao Xia. ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death & Disease. 2018. Jul 9;9(7):762. (IF=6.3, JCR2区)
9.Bing Luo^#, Yuchun Lin^#, Shengwei Jiang, Lianyun Huang, Huan Yao, Qunying Zhuang, Ran Zhao, Hengchuan Liu, Chengyong He*, Zhongning Lin*. Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney. Cell Death & Disease. 2016;7: e2251; doi:10.1038/cddis.2016.78. (IF=6.3, JCR2区)
10.Chuanli Yang, Peiyu Han, Fengkai Ruan, Tengjian Zhou, Bing Luo, Yang Qiu, Yuchun Lin, Zhongning Lin*, Chengyong He*. Lactational exposure to environmentally relevant benzo(a)pyrene causes astrocytic activation and anxiety-like behavior in male mice. Chemosphere. 2019.221: 67e74. (IF=5.778, JCR2区)
11. Chen Tang, Chao Shen, Kongyang Zhu, Yixi Zhou, Yung-Jen Chuang, Chengyong He?, Zhenghong Zuo*. Exposure to the AhR agonist cyprodinil impacts the cardiac development and function of zebrafish larvae. Ecotoxicology and Environmental Safety 201 (2020) 110808 (IF=4.87, JCR2区)
12. Naying Zheng, Jinhui Yan, Wang Qian, Chao Song, Zhenghong Zuo, Chengyong He*. Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos. Journal of Environmental Sciences-China 2021.10.1016/j.jes.2020.07.019 (IF=4.302, JCR2区)
13.Jinhui Yan, Shujing Chen, Zhenghong Zuo, Chengyong He*, Muqing Yi*. Graphene oxide quantum dot exposure induces abnormalities in locomotor activities and mechanisms in zebrafish (Danio rerio). Journal of Applied Toxicology. 2020;40:794–803. (IF=2.997, JCR2区)
14.Chengyong He, Zhenghong Zuo, Xiao Shi, Lingbin Sun, Chonggang Wang*, Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos. Aquatic Toxicology. 2012:124-125C;28-33. (IF=4.344, JCR2区)
15.Chengyong He, Chonggang Wang, Bowen Li, Meifang Wu, Hong Geng, Yixin Chen, Zhenghong Zuo*. Exposure of Sebastiscus marmoratus embryos to pyrene results in neurodevelopmental defects and disturbs related mechanisms. Aquatic Toxicology. 2012;116-117: 109-115. (IF=4.344, JCR2区)
16.Chengyong He, Zhenghong Zuo, Xiao Shi, Ruixia Li, Donglei Chen, Xin Huang, Yixin Chen, Chonggang Wang*. Effects of Benzo(a)Pyrene on the skeletal development of Sebastiscus marmoratus embryos and the molecular mechanism involved. Aquatic Toxicology. 2011;101:335–341. (IF=4.344, JCR2区)
17.Chengyong He, Chonggang Wang, Yulin Zhou, Jian Li, Zhenghong Zuo*. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus). Neurotoxicology. 2012; 33:758-762. (IF=3.105, JCR3区)
18.Chengyong He, Chonggang Wang, Bowen Li, Fazhi Xie, Yixin Chen, Zhenghong Zuo*. Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2009; 154(2):221-228. (IF=2.219, JCR4区)
19.Junxia Shi, Chenyu Liu, Mingyue Chen, Jinhui Yan, Chonggang Wang, Zhenghong Zuo^*, Chengyong He*. The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells. Environmental Toxicology. (Nov. 2020, Accepted) (IF=3.118, JCR3区)
20.Kongyang Zhu, Chao Shen, Chen Tang, Yixi Zhou, Chengyong He*, Zhenghong Zuo*. Improvement in the screening performance of potential aryl hydrocarbon receptor ligands by using supervised machine learning. Chemosphere. (Nov. 2020, Accepted) (IF=5.778, JCR2区)
荣誉和奖励：
教学、科研和人才培养等方面多次获得奖励如下：
1. 2020年指导本科生获得全国大学生生命科学竞赛二等奖1项
2. 指导或协助指导研究生获得国家奖学金6人次(2014、2015、2016、2017、2020)
3. 2020年获得厦门大学清源奖教金
4. 2017年获得四川美特生物奖教金
5. 2016年获得中国毒理学会第五次中青年****科技论坛优秀论文奖(口头汇报)
6. 2015年获得厦门大学养生堂奖教金