李剑LI Jian, Ph.D.
副教授
电话：+86-
E-mail: jianli_204@xmu.edu.cn

2019-至今，厦门大学生命科学学院，副教授
2011-2019，厦门大学生命科学学院，助理教授
2009-2011，美国国立卫生研究院(NIH)，联培博士生
2005-2011，厦门大学生命科学学院，博士
2000-2004，南昌大学生命科学学院，学士


2019-present, Associate professor, Xiamen University
2011-2019, Assistant professor, Xiamen University
2009-2011, Joint PhD student, National Institutes of Health, USA
2005-2011, Ph.D., School of Life Sciences, Xiamen University
2000-2004, B.S., School of Life Sciences, Nanchang University




研究领域（Research Area)


1. 疟原虫抗药的遗传机制

2. 寄生虫-宿主互作的致病性毒力分子机制
1. Genetic basis of drug resistance in malaria parasite
2. Molecular mechanism of virulence involved in parasite-host interactions




代表性论文(Selected Publications)



1. Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su X-z*, Li J*: Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method. Int J Parasitol 2019, 49(9): 705-14.
2. Nair SC^#, Xu R^#, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA,Li J*, Su X-z*: A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence.Nature Communications2017, 8(1): 223.
3 Su XZ*, Li J. Artemisinin and malaria: Current understandings of drug activation, action, and resistance. Chin Sci Bull 2017, 62(18): 1928-1937.
4. Yu X^#, Cai B^#, Wang M, Tan P, Ding X, Wu J,Li J, Li Q, Liu P, Xing C, Wang HY, Su X-z*, Wang R-F*: Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.Immunity2016, 45(5): 1093-1107.
5. Li J*, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Qui?ones M, Su X-z*: UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies. Malar J2016, 15: 30.
6. Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J*, Huang F*, Su X-z*: Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA.mBio2015, 6(2): e00117-15.
7. Zhao W, Liu J, Xu R, Zhang C, Pang Q, Chen X, Liu S, Hong L, Yuan J, Li X, Chen Y, Li J*, Su X-z*: The Gametocytes of Leucocytozoon sabrazesi Infect Chicken Thrombocytes, Not Other Blood Cells. PLoS One2015, 10(7): e**.
8. Wu J, Tian L, Yu X, Pattaradilokrat S,Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R*, Su X-z*: Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality. Proc Natl Acad Sci USA2014, 111(4): E511-E520.
9. Pattaradilokrat S, Li J, Wu J, Qi Y, Eastman RT, Zilversmit M, Nair SC, Huaman MC, Quinones M, Jiang H, Li N, Zhu J, Zhao K, Kaneko O, Long CA, Su X-z*. Plasmodium genetic loci linked to host cytokine and chemokine responses. Genes Immun2014, 15(3):145-152.
10. Li J, Yuan J, Chen CC, Inglese J, Su X-z*: Chemical genomics for studying parasite gene function and interaction.Trends in Parasitol2013, 29(12): 603-611.
11. Li J^#, Pattaradilokrat S^#, Zhu F^#, Jiang H, Liu S, Hong L, Fu Y, Koo L, Xu W, Pan W, Carlton JM, Kaneko O, Carter R, Wootton JC, Su X-z*: Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii. Proc Natl Acad Sci USA2011, 108(31): E374-E382.
12.Jiang H, Li N, Gopalan V, Zilversmit MM, Varma S, Nagarajan V, Li J, Mu J, Zilversmit M, Hayton K, Henschen B, Yi M, Stephens R, McVean GA, Awadala P, Wellems TE, Su X-z*. High chromosome recombination rates and hotspots in a Plasmodium falciparum genetic cross. Genome Biology2011, 12(4): R33.
13.Pattaradilokrat S, Li J, Su X-z*: Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites. J Vis Exp 2011, (47). pii: 2365.
14.Li J, Zhang Y, Liu S, Hong L, Sullivan M, McCutchan TF, Carlton JM, Su X-z*: Hundreds of microsatellites for genotyping Plasmodium yoelii parasites. Mol Biochem Parasit2009, 166(2): 153-158.
15.Li J, Zhang Y, Sullivan M, Hong L, Huang L, Lu F, McCutchan TF, Su X-z*: Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method. Mol Biochem Parasit2007, 155(2): 94-102.