刘亮，博士LIU Liang, Ph.D.
教授，博士生导师Professor
RNA加工与调控 (RNA processing and regulation)
E-mail：liangliu2019@xmu.edu.cn


简历 (Education and Work experience)
2006-2010年，中南民族大学生命科学学院，学士学位；
2010-2015年，华南理工大学生物科学与工程学院，博士学位；
2012-2015年，北京大学基础医学院，访问博士生；
2015-2019年，中国科学院生物物理研究所，博士后；
2018-2019年，中国科学院生物物理研究所，副研究员；
2019年至今，厦门大学生命科学学院，教授。


2006-2010,School of Life Sciences, South-central University For Nationalities, B.S.
2010-2015, School of Biology and Biological Engineering, South China University of Technology, Ph.D.
2012-2015, School of Basic Medical Sciences, Peking University, Visiting Scholar.
2015-2019, Institute of Biophysics, Chinese Academy of Sciences,Postdoctoral Fellow
2018-2019, Institute of Biophysics, Chinese Academy of Sciences, Associate Professor.
2019-, School of Life Sciences, Xiamen University, Professor.


研究领域 (Research Area)
真核生物基因组有相当大的部分会被转录成RNA。在细胞内，除负责编码蛋白质的mRNA以外，还存在大量的非编码RNA，其中包括长链非编码RNA (lncRNA)、转运RNA (tRNA)、核糖体RNA (rRNA)等。RNA的异常转录以及错误加工或修饰，都会导致核糖核蛋白体的异常装配，干扰细胞内正常的基因表达和调节。本课题组运用结构生物学、生物化学与分子生物学、细胞生物学及多种组学研究手段及技术，重点开展以下几个方面的研究：
RNA加工与修饰
RNA介导的基因表达与调控的结构生物学研究
RNA调控机体免疫应答的分子机制
For eukaryotes, a large portion of the genome is transcribed into RNA. Inaddition to mRNA, there are plenty of non-coding RNA in cells, which includes lncRNA, tRNA, rRNA and so on. The aberrant transcription and processing of RNA will lead to abnormal assembly of ribonucleoprotein, disturbing normal gene expression and regulation in cells. Touncover the biological functions of RNA, our lab focus on the following areas:
RNA processing and modification
Structural studies of RNA mediated gene expression and regulation
The functions and mechanisms of RNA in regulating immune response


代表性论文 (Selected Publications)：
1. Liu L, Yin M, Wang M, Wang Y. Phage AcrⅡA2 DNA Mimicry: Structural Basis of the CRISPR/anti-CRISPR Arms Race. Molecular Cell. 2019; 73(3):611-620.e3.
2. Liu L^#, Li X^#, Ma J^#, Li Z^#, You L, Wang J, Wang M, Zhang X, Wang Y. The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. Cell. 2017; 170:714-726. (^# Co-firstauthor)
3. Liu L, Li X, Wang J, Yin M, Chen P, Wang M, Li J, Sheng G, Wang Y. Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities. Cell. 2017; 168:121-134.
4. Liu L, Chen P, Wang M, Li X, Wang J, Yin M, Wang Y. C2c1-sgRNA Complex Structure Reveals RNA-guided DNA Cleavage Mechanism. Molecular Cell. 2017; 65(2):310-322.
5. Liu L^#, Chen JY^#, Yang B, Wang FH, Wang YH, Yun CH. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function. Structure. 2015; 23:2066-75. (^# Co-firstauthor)
6. Liu L, Chen J, Yang B, Wang Y. Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins.Biochem Biophys Res Commun. 2015; 458:429-34.
7. Liu L, Chen J, Yang B, Wang Y. Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions. FEBS Open Bio. 2015; 5:155-62.
8. Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y；Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States；Molecular Cell. 2019; pii: S1097-2765(19)30730-0. doi: 10.1016/j.molcel.2019.09.025. [Epub ahead of print]
9.You L, Ma J, Wang J, Artamonva D, Wang M, Liu L, Xiang X, Severinov K, Zhang X, Wang Y; Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference; Cell. 2019; 176(1-2):239-253.e16.
10. Zhao X, Liu L,Lang J, Cheng K, Wang Y, Li X, Shi J, Wang Y, Nie G. A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment. Cancer Lett. 2018; 431:171-181.
11.Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. Sci Rep. 2016; 6:31425.


荣誉、奖励及参加学术团体的情况(Honors and award)
2019年入选厦门大学南强青年拔尖人才A类
2018年获北京市科学技术奖二等奖（排名第三）
Young Top Talents Program of Xiamen University (2019)
Second Prize of Beijing Science and Technology Award (2018)