揭祖亮，博士 Jie Zuliang, Ph.D.
教授，博士生导师 Professor
肠道与肿瘤免疫学 (Intestine and tumor Immunology)
电 话：
E-mail：jiezuliang@126.com


2005年，厦门大学生物科学专业，学士学位；
2008年，厦门大学生化与分子生物学专业，硕士学位；
2014年，德克萨斯大学医学院微生物与免疫学专业，博士学位；
2015-2020年，德克萨斯大学安德森癌症中心免疫系，博士后；
2020年，厦门大学生命科学学院，教授
B.S. Biology, Xiamen University, 2005;
M.S. Biochemistry and Molecular Biology, Xiamen University, 2008;
Ph.D. Microbiology and Immunology, University of Texas Medical Branch, 2014;
Postdoctoral Fellow, University of Texas MD Anderson Cancer Center, 2015-2020;
Professor, School of Life Sciences, Xiamen University, 2020


研究领域（Research Area）


肠道肿瘤是世界上常见且致死率很高的恶性肿瘤之一。肠道菌群、肠道上皮细胞及免疫细胞相互协作并在维持肠道稳态中起重要作用。我们将利用肠道肿瘤模型，研究探索肠道上皮细胞以及肠道菌群如何调节肠道免疫以及肿瘤生长，为治疗肠道肿瘤疾病提供新的靶点和思路。
Accumulating evidence suggests that a mutualism between the mucosal immune system and the commensal microbiota has important implications for the maintenance of intestinal immune homeostasis. However, alterations in communication between the host immune system and gut microbiome have been implicated as the important defect that leads to development of colon cancer and chronic intestinal inflammation. In our lab, we will investigate the underlying mechanisms of how intestine epithelial cells and microbiota regulate tumorigenesis and immune responses. These steps can be targeted for better clinical intervention for colon cancer.


代表性论文（Selected Publications, * Corresponding author）
1. Jie Z^#, Yang JY^#, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, Cheng X, Sun SC. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nature Immunol. 2018. 19(11): 1224-1235.(^#co-first author)
2. Wang B^#, Jie Z^#, Joo D, Ordureau A, Liu P, Gan W, Guo J, Zhang J, North BJ, Dai X, Cheng X, Bian X, Zhang L, Harper JW, Sun SC, Wei W. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signaling. Nature. 2017. 545(7654):365-369.(^#co-first author)
3. Jie Z^#, Liang Y^#, Yi P, Tang H, Soong L, Cong Y, Zhang K, Sun J. Retinoic acid regulates immune responses by promoting IL-22 and modulating S100 proteins in viral hepatitis. J. Immunol. 2017.198(9):3448-3460.
4. Hou L^#, Jie Z^#, Liang Y#, Desai M, Soong L, Sun J. Type 1 interferon-induced IL-7 maintains CD8+ T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis. Cell Mol Immunol. 2015.12(2):213-21. (#co-first author)
5. Jie Z, Liang Y, Hou L, Dong C, Iwakura Y, Soong L, Cong Y, Sun J. Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection. J. Immunol. 2014.192:3289-300.
6. Hou L^#, Jie Z^#, Desai M, Liang Y, Soong L, Wang T, Sun J. Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis. J. Immunol. 2013.190:621-9. (#co-first author)
7. Yan J^#, Jie Z^#, Hou L, Wanderley JL, Soong L, Gupta S, Qiu S, Chan T, Sun J. Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice. Hepatology. 2011.53:1455-67. (^#co-first author)
8. Zhu L, Li Y, Xie X, Zhou X, Gu M, Jie Z, Ko CJ, Gao T, Hernandez BE, Cheng X, Sun SC. TBKBP1 and TBK1 form a growth factor signaling axis mediating immunosuppression and tumourigenesis. Nat Cell Biol. 2019. 21(12):1604-14.
9. Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC. Preventing abnormal NF-kB activation and autoimmunity by Otub1-mediated p100 stabilization. Cell Res. 2019. 29:474-485.
10. Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, Shi J, Zhao S, Zhang B, Cheng X, Sun SC. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nature Commun. 2018.9(1):2812.
11. Xiao Y^#, Zou Q^#, Xie X^#, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J. Exp. Med. 2017.214(5):1493-1507.(#co-first author)
12. Zou Q, Jin J, Xiao Y, Hu H, Zhou X, Jie Z, Xie X, Li JY, Cheng X, Sun SC. T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J. Exp. Med. 2015. 212(8):1323-36.


荣誉、奖励及参加学术团体的情况(Honors and award)

2019 Center for Inflammation and Cancer Scholar Award,Univ. Texas MD Anderson CancerCenter
2018 Award of Oral Presentation in Immunology Program Scientific Retreat, Galveston, TX
2017 The Jeffrey Lee Cousins Fellowship in Lung Cancer Research, The University of Texas MDAnderson Cancer Center, Houston, TX
2014 American Association of Immunologists Trainee Abstract Award, Pittsburg, PA
2013 American Association of Immunologists Trainee Abstract Award, Honolulu, HI
2013 The Robert E. Shope Ph.D. Endowed Scholarship, The University of Texas Medical Branch,Galveston, TX
2012 American Society for Virology Student Travel Award, Madison, WI
2011 The James W. McLaughlin Pre-doctoral Fellowship, The University of Texas Medical Branch,Galveston, TX