李莉，博士 LI Li, Ph.D.
特任副研究员
化学生物学 (Chemical biology)


电 话：+86-
传 真：+86-
E-mail：lli@xmu.edu.cn


简历 (Education and Work experience)
2008年，厦门大学生物科学专业，学士学位；
2013年，厦门大学细胞与分子生物学专业，博士学位；
2015年，厦门大学生命科学学院，工程师；
2019年，厦门大学生命科学学院，助理教授，
2021年-至今，厦门大学生命科学学院，特任副研究员。
B.S. Life Science, Xiamen University, 2008
Ph.D. Cellular & Molecular Biology, Xiamen University, 2013
Engineer, School of Life Sciences, Xiamen University, 2015
Assistant Professor, School of Life Sciences, Xiamen University, 2019


研究领域 (Research Area)
?靶向新颖激酶的活性小分子药物研发
?新颖药物靶标的功能及分子调控机制研究
?Development of small molecule drugs targeting novel kinases
?Functional and regulatory mechanism study on potential therapeutic targets



代表性论文 (Selected Publications) (# first author,* corresponding author)：
1.Li, L.^#, Liu, Y.#, Chen, H. Z.#, Li, F. W.#, Wu, J. F., Zhang, H. K., He, J. P., Xing, Y. Z., Chen, Y., Wang, W. J., Tian, X. Y., Li, A. Z., Zhang, Q., Huang, P. Q., Han, J., Lin, T.*, and Wu, Q.* (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nature chemical biology 11, 339-346
2.Chen, H. Z.#, Liu, Q. F.#, Li, L.^#, Wang, W. J., Yao, L. M., Yang, M., Liu, B., Chen, W., Zhan, Y. Y., Zhang, M. Q., Cai, J. C., Zheng, Z. H., Lin, S. C., Li, B. A.*, and Wu, Q.* (2012) The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling. Gut 61, 714-724
3.Yin, C.#, Zhu, B.#, Zhang, T.#, Liu, T., Chen, S., Liu, Y., Li, X., Miao, X., Li, S., Mi, X., Zhang, J., Li, L., Wei, G., Xu, Z. X., Gao, X., Huang, C., Wei, Z., Goding, C. R., Wang, P.*, Deng, X.*, and Cui, R.* (2019) Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell 176, 1113-1127 e1116
4.Liu, Z. H.#, Li, Y. Z.#, Li, W.#, Lian, W. H., Kemell, M., Hietala, S., Figueiredo, P., Li, L., Makila, E., Ma, M., Salonen, J., Hirvonen, J. T., Liu, D. F., Zhang, H. B.*, Deng, X. M.*, and Santos, H. A.* (2019) Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing. Mater Horiz 6, 385-393
5.Gui, F.#, Jiang, J.#, He, Z.#, Li, L., Li, Y., Deng, Z., Lu, Y., Wu, X., Chen, G., Su, J., Song, S., Zhang, Y. M., Yun, C. H., Huang, X., Weisberg, E., Zhang, J.*, and Deng, X.* (2019) A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant Btk(C481S) mutation in B-cell malignancies. Br J Pharmacol
6.Tian, M.#, Zeng, T.#, Liu, M., Han, S., Lin, H., Lin, Q., Li, L., Jiang, T., Li, G., Lin, H., Zhang, T., Kang, Q., Deng, X.*, and Wang, H. R.* (2018) A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases. J Biol Chem 294, 2880-2891
7.Huang, W.#, Sun, X.#, Li, Y., He, Z., Li, L., Deng, Z., Huang, X., Han, S., Zhang, T., Zhong, J., Wang, Z., Xu, Q., Zhang, J.*, and Deng, X.* (2018) Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities. J Med Chem 61, 5424-5434
8.Jin, K.#, Li, L., Sun, X., Xu, Q., Song, S., Shen, Y., and Deng, X.* (2017) Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway. Applied microbiology and biotechnology 101, 4201-4213
9.Jiang, J.#, Gui, F.#, He, Z.#, Li, L., Li, Y., Li, S., Wu, X., Deng, Z., Sun, X., Huang, X., Huang, W., Han, S., Zhang, T., Wang, Z., Jiao, B., Song, S., Wang, H., Chen, L., Zhou, D., Liu, Q., Ren, R.*, Zhang, J.*, and Deng, X.* (2017) Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors. Cancer research 77, 175-186
10.Huang, X.#, Huang, W.#, Li, L., Sun, X., Song, S., Xu, Q., Zhang, L., Wei, B. G.*, and Deng, X.* (2016) Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis. Molecular pharmaceutics 13, 3756-3763
11.Chen, Y.#, Wu, R.#, Chen, H. Z.#, Xiao, Q., Wang, W. J., He, J. P., Li, X. X., Yu, X. W., Li, L., Wang, P., Wan, X. C., Tian, X. H., Li, S. J., Yu, X., and Wu, Q*. (2015) Enhancement of hypothalamic STAT3 acetylation by nuclear receptor Nur77 dictates leptin sensitivity. Diabetes 64, 2069-2081
12.Wang, W. J.#, Wang, Y.#, Chen, H. Z.#, Xing, Y. Z.#, Li, F. W.#, Zhang, Q., Zhou, B., Zhang, H. K., Zhang, J., Bian, X. L., Li, L., Liu, Y., Zhao, B. X., Chen, Y., Wu, R., Li, A. Z., Yao, L. M., Chen, P., Zhang, Y., Tian, X. Y., Beermann, F., Wu, M., Han, J., Huang, P. Q., Lin, T.*, and Wu, Q*. (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature chemical biology 10, 133-140
13.Lee, S. O.#, Li, X., Hedrick, E., Jin, U. H., Tjalkens, R. B., Backos, D. S., Li, L., Zhang, Y., Wu, Q., and Safe, S*. (2014) Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Molecular endocrinology (Baltimore, Md.) 28, 1729-1739
14.Chen, H. Z.#, Li, L., Wang, W. J., Du, X. D., Wen, Q., He, J. P., Zhao, B. X., Li, G. D., Zhou, W., Xia, Y., Yang, Q. Y., Hew, C. L., Liou, Y. C., and Wu, Q*. (2012) Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene 31, 2876-2887
15.Chen, H. Z.#, Zhao, B. X., Zhao, W. X., Li, L., Zhang, B., and Wu, Q*. (2008) Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. Carcinogenesis 29, 2078-2088


授权专利 (Patent)：

吴乔, 张洪奎, 黄培强, 李莉, 林天伟, 陈航姿, 刘元. 2-[3,5-二羟基-2-(1-酰基)苯基]乙酸酯的应用. 中国


荣誉、奖励及参加学术团体的情况 (Honors and award)

2017年度福建省自然科学一等奖
“中国病理生理学会十三届肿瘤、十四届免疫专业委员会学术会议”青年优秀论文三等奖