Curriculum Vitae
姚翠鸾








一、基本概况
教授，博士生导师；
2005年毕业于中国科学院海洋研究所，获博士学位。福建省首批****基金获得者；福建省新世纪优秀人才支持计划获得者；厦门市巾帼建功标兵；福建省巾帼建功标兵。
Email：clyao@jmu.edu.cn;
Tel：+86-
Fax：+86-
通讯地址：厦门市集美区印斗路43号，集美大学水产学院，361021
二、研究工作经历
2013.9-2014.3，斯坦福大学生物系，高级研究****
2009.9-2010.9，斯坦福大学生物系，博士后研究****；
2006.6-今，集美大学水产学院，2009年任教授；
2005.3-2006.6，河北大学生命科学学院生物技术系，副教授；
2002.3－2005.3，中国科学院海洋研究所实验海洋生物学与生物技术重点实验室；
三、研究兴趣
针对主要海洋经济动物养殖过程中的病害频发及养殖环境恶化等问题，从生物体的抗病免疫、胁迫响应及调控机理等方面，对生命活动规律及机理进行探究。
主要研究方向包括：
1、鱼类Toll样受体介导的病原识别及免疫激活；
2、鱼虾重要免疫基因的功能鉴定、抗病机制、重组表达及应用；
3、环境胁迫导致的海洋动物损伤、凋亡及调控；
四、主讲课程：
本科生：细胞生物学；
研究生：细胞信号传导及调控。
五、学术兼职
教育部动物医学教学指导委员会委员
香港Research Grant Council (RGC)，国际评审专家
Journal of Immunology Research,特邀编辑
国家自然科学基金委，评审专家
Fish & Shellfish Immunology, Plos One, Chemosphere, Comp Physiol Biochem,等10余个刊物，审稿人
六、近年来主持的研究项目
1.国家重点基础研究（973）项目，“大黄鱼抗病分子育种的基础研究”（2011CB111604），主持人
2.国家重点基础研究（973）项目“重要海水养殖动物病害发生和免疫防治的基础研究”，子课题主持人。
3.国家自然科学基金，“大黄鱼依赖MyD88的Toll样受体信号传导途径研究”（**），主持人
4.福建省****基金，“大黄鱼TLR9抗病途径解析及抗病候选基因鉴定”(2009J06019)，主持人
5.国家自然科学基金项目，“一氧化氮在对虾免疫应答中的角色及调控”（**），主持人
6.国家自然科学基金面上项目“精氨酸激酶在对虾免疫应答中的作用及机理”（**），主持人
7.国家自然科学基金项目“全球温度变化对海洋贝类DNA损伤、细胞凋亡及其适应能力影响”（**），主持人,
8.2007年入选福建省优秀人才支持计划
另外参与国家973、863、美国自然科学基金、国际合作等多项合作计划项目。
七、代表论著
1.Qiao-Jing Jia, Ze-Jun Fan,Cui-Luan Yao*,Identification and expression profiles of ERK2 and ERK5 in large yellow croaker (Larimichthys crocea) after temperature stress and immune challenge.Fish Shellfish Immunology,2015,44(2): 410-419.
doi:10.1016/j.fsi.2015.03.006
2.Fan ZJ, Jia QJ,Yao CL*, 2015. Characterization and expression analysis of Toll-like receptor 2 gene in large yellow croaker, Larimichthys crocea. Fish & Shellfish Immunology, 2015, 44(1):129-37.doi:10.1016/j.fsi.2015.01.037
3.Zhang D, Wang HW,Yao CL*. 2014.Molecular and acute temperature stress response characterizations of caspase-8 gene in two mussels, Mytilus coruscus and Mytilus galloprovincialis. Comp Biochem Physiol B Biochem Mol Biol. 2014; 177-178:10-20.doi:10.1016/j.cbpb.2014.08.002
4.Yao CL*, Somero GN, 2014.The impact of ocean warming on marine organisms.Chinese Science Bulletin 2014, 59(5-6): 468-479.Free Article .
5.Yao CL*, Somero GN. Thermal stress and cellular signaling processes in hemocytes of native (Mytilus californianus) and invasive (M. galloprovincialis) mussels: Cell cycle regulation and DNA repair. Comp Biochem Physiol A Mol Integr Physiol. 2013; 165(2): 159-68.doi:10.1016/j.cbpa.2013.02.024 .
6.Yao CL*, Somero GN, 2012.The impact of acute temperature stress on hemocytes of invasive and native mussels (Mytilus galloprovincialis andMytilus californianus): DNA damage, membrane integrity, apoptosis and signaling pathways.J Exp Biol. 215:4267-77.Free article
7.Li C,Yao CL*, 2013.Molecular and expression characterizations of Interleukin-8 gene in large yellow croaker (Larimichthys crocea).Fish Shellfish Immunol, 34(3):799-809.
doi:10.1016/j.fsi.2012.12.019.
8.Yao CL, Huang XN, Fan Z, et al.,2012.Cloning and expression analysis of interferon regulatory factor (IRF)3 and 7 in large yellow croaker,Larimichthys crocea.Fish Shellfish Immunol, 32(5):869-78.doi:10.1016/j.fsi.2012.02.015
9.Huang XN, Wang ZY,Yao CL*,2011. Characterization of Toll-like receptor 3 gene in large yellow croaker,Pseudosciaena crocea.Fish Shellfish Immunol,31 (1): 98-106.doi:10.1016/j.fsi.2011.04.009
10.Yang QL,Yao CL*, Wang ZY,2012. Acute temperature and cadmium stress response characterization of small heat shock protein 27 in large yellow croaker, Larimichthys crocea.Comp Biochem Physiol C: Toxicol Pharmacol. 155(2):190-7.
doi:10.1016/j.cbpc.2011.08.003
11.Yao CL, Kong P, Wang ZY, et al.,2009.Cloning and expression analysis of MyD88 in large yellow croaker,Pseudosciaena crocea.Fish Shellfish Immunol, 26 (2): 249-255.
doi:10.1016/j.fsi.2008.10.014
12.Yao CL, Kong P, Wang ZY, et al.,2008.Cloning and expression analysis of two alternative splicing toll-like receptor 9 isoforms A and B in large yellow croaker,Pseudosciaena crocea.Fish Shellfish Immunol,25 (5): 648-656.doi:10.1016/j.fsi.2008.07.006
13.Ji PF,Yao CL*, Wang ZY,2011. Reactive oxygen system plays important role in shrimp (Litopenaeus vannamei) defense against Vibrio parahaemolyticus and WSSV infection.Dis Aquat Organ. 96(1):9-20.doi:10.3354/dao02373
14.Ji PF,Yao CL*, Wang ZY,2011. Two types of calmodulin play different roles in Pacific white shrimp (Litopenaeus vannamei) defenses againstVibrio parahaemolyticus and WSSV infection.Fish Shellfish Immunol, 31:260-268.doi:10.1016/j.fsi.2011.05.011
15.Yao CL, Ji PF, Wang ZY, Li F, Xiang JH*,2010.Molecular cloning and expression of NOS in shrimp,Litopenaeus vannamei.Fish Shellfish Immunol,28 (3): 453-460.doi:10.1016/j.fsi.2009.12.002
16.Ji PF,Yao CL*, Wang ZY. 2009.Immune response and gene expression in shrimp (Litopenaeus vannamei) hemocytes and hepatopancreas against some pathogen-associated molecular patterns.Fish Shellfish Immunol, 2009, 27(4) 563-570.doi:10.1016/j.fsi.2009.08.001
17.Yao CL, Ji PF, Kong P, Wang ZY, Xiang JH*.2009. Arginine kinase fromLitopenaeus vannamei: cloning, expression, enzymatic properties and interactive pathway.Fish Shellfish Immunol. 26 (3): 553-558.doi:10.1016/j.fsi.2009.02.012.
18.Yao CL，Wu CG, Xiang JH*, et al.,2008.The lysosome and lysozyme response in Chinese shrimpFenneropenaeus chinensis to Vibrio anguillarum and laminarin stimulation.J Exp Mar Biol Ecol. 363: 124-129.doi:10.1016/j.jembe.2008.06.035
19.Yao CL, Wang AL*, Wang ZY, Wang WN, Sun RY. Purification and Partial Characterization of CuZn Superoxide Dismutase from hemocyte of Oriental prawn,Microbrachium nipponense.Aquaculture.270: 559-565.
doi:10.1016/j.aquaculture.2007.04.068
20.Yao CL, Wu CG, Xiang JH*, Dong B. Molecular cloning and response to laminarin stimulation of arginine kinase in haemolymph in Chinese Shrimp,Fenneropenaeus chinensis.Fish Shellfish Immunol, 19 (4): 317-329.doi:10.1016/j.fsi.2005.01.006.
八、国际学术交流与合作
2014.7月，邀请美国科学家来访；
2013.9月-2014.3月，赴美国Stanford大学进行科学研究；
2013.3月，应邀赴台湾中兴大学、嘉义大学、东海大学、台湾海洋生物研究所进行学术访问与交流，并做学术报告；
2012.11月：邀请美国科学家来实验室进行学术交流与合作；
2012.7月： 赴Fukuoka参加第十二届国际发育与比较免疫学大会，并作口头报告；
2011.1月：应邀赴香港大学Swire海洋研究所及香港中文大学生命科学学院进行学术访问与交流，并做学术报告；
2010.8月，赴美国科罗拉多州Denver参加美国生理学大会，做口头报告；
2009.9月－2010.9月：赴美国Stanford大学进行科学研究；
2008.5月：赴韩国参加世界水产养殖大会，做口头报告
（last updated 4/26/2015）



Dr. Cui-Luan Yao






Cui-Luan Yao
Professor in Fisheries College of Jimei University, Xiamen, China.
Email：clyao@jmu.edu.cn;
Tel：+86-;
Fax：+86-
Address: Fisheries College of Jimei University, Yindou Road 43, Xiamen City, 361021, China
Research interests:
The role of Toll-like receptor pathway in marine fish immune response
The effect of environmental stress on DNA damage, apoptosis and the animal adaptation
Antioxidant system response and energy metabolism in shrimp immune response
Research experiences
09/2013-03/2014, Senior Visiting Scientists, Stanford, USA
09/2009-09/2010, Visiting Scientists, Stanford, USA
09/2009-present, Professor, Jimei University, teaching Cell Biology
06/2006-09/2009, Associate Professor, Jimei University, teaching Cell Biology
03/2005-06/2006, Associate Professor in Hebei University, teaching Biochemistry
03/2002-03/2005, Ph. D. candidate Researcher in Institute of Oceanology, Chinese Academy of Sciences
Principle investigator of Grants (From 2007-Present)
1.National Basic Research Program of China (973 program). “The role of Toll like receptor pathway in large yellow croaker Larimichthys crocea defense against infection”No. 2011CB111604, Apr. 2011-Dec. 2014;
2.National Natural Science Foundational of China. “The role and function of MyD88 in TLR pathway of large yellow croaker, Larimichthys crocea” No. **, Jan. 2012-Dec. 2014 ;
3.Nature Science Foundation for young talent scientists of Fujian Province. The signal transduction and candidate disease resistance genes in TLR9 pathway of large yellow croaker, Larimichthys crocea”. No. 2009J06019, Jul. 2009-Jul. 2012;
4.National Natural Science Foundational of China. “The effect of temperature change on DNA damage, apoptosis and the adaptation of mussels” No. **, Jan. 2011-Dec. 2013;
5.National Natural Science Foundational of China. “The function and regulation mechanisms of arginine kinase in immune response of Chinese shrimp (Fenneropenaeus chinensis)” No. **, Jan 2007-Dec 2009;
6.“The synthesis and regulation of NOS in shrimp immune response”, supported by Major State Basic Research Development Program of China (973 program, 2006CB101804). (Joint Grant with Prof. Jianhai Xiang, IOCAS, principle investigator: Prof. Jianhai Xiang) 2007-2009.
7.“Molecular cloning and expression of some TLR genes in large yellow croaker”, supported by “Program for New Century Excellent Talents in University of Fujian province”, 2009-2011
Selected publications (“*” represents corresponding author)
1.Qiao-Jing Jia, Ze-Jun Fan, Cui-Luan Yao*,Identification and expression profiles of ERK2 and ERK5 in large yellow croaker (Larimichthys crocea) after temperature stress and immune challenge. Fish Shellfish Immunology, 2015, 44(2): 410-419. doi:10.1016/j.fsi.2015.03.006
2.Fan ZJ, Jia QJ, Yao CL*, 2015. Characterization and expression analysis of Toll-like receptor 2 gene in large yellow croaker, Larimichthys crocea. Fish & Shellfish Immunology, 2015, 44(1):129-37.doi:10.1016/j.fsi.2015.01.037
3.Zhang D, Wang HW, Yao CL*. 2014. Molecular and acute temperature stress response characterizations of caspase-8 gene in two mussels, Mytilus coruscus and Mytilus galloprovincialis. Comp Biochem Physiol B Biochem Mol Biol. 2014; 177-178:10-20. doi:10.1016/j.cbpb.2014.08.002
4.Yao CL*, Somero GN, 2014. The impact of ocean warming on marine organisms. Chinese Science Bulletin 2014, 59(5-6): 468-479. Free Article .
5.Yao CL*, Somero GN. Thermal stress and cellular signaling processes in hemocytes of native (Mytilus californianus) and invasive (M. galloprovincialis) mussels: Cell cycle regulation and DNA repair. Comp Biochem Physiol A Mol Integr Physiol. 2013; 165(2): 159-68. doi:10.1016/j.cbpa.2013.02.024 .
6.Yao CL*, Somero GN, 2012. The impact of acute temperature stress on hemocytes of invasive and native mussels (Mytilus galloprovincialis and Mytilus californianus): DNA damage, membrane integrity, apoptosis and signaling pathways.J Exp Biol. 215:4267-77. Free article
7.Li C, Yao CL*, 2013. Molecular and expression characterizations of Interleukin-8 gene in large yellow croaker (Larimichthys crocea). Fish Shellfish Immunol, 34(3):799-809. doi:10.1016/j.fsi.2012.12.019.
8.Yao CL, Huang XN, Fan Z, et al., 2012. Cloning and expression analysis of interferon regulatory factor (IRF)3 and 7 in large yellow croaker, Larimichthys crocea. Fish Shellfish Immunol, 32(5):869-78. doi:10.1016/j.fsi.2012.02.015
9.Huang XN, Wang ZY, Yao CL*, 2011. Characterization of Toll-like receptor 3 gene in large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol,31 (1): 98-106. doi:10.1016/j.fsi.2011.04.009
10.Yang QL, Yao CL*, Wang ZY, 2012. Acute temperature and cadmium stress response characterization of small heat shock protein 27 in large yellow croaker, Larimichthys crocea. Comp Biochem Physiol C: Toxicol Pharmacol. 155(2):190-7. doi:10.1016/j.cbpc.2011.08.003
11.Yao CL, Kong P, Wang ZY, et al., 2009. Cloning and expression analysis of MyD88 in large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol, 26 (2): 249-255. doi:10.1016/j.fsi.2008.10.014
12.Yao CL, Kong P, Wang ZY, et al., 2008. Cloning and expression analysis of two alternative splicing toll-like receptor 9 isoforms A and B in large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol, 25 (5): 648-656. doi:10.1016/j.fsi.2008.07.006
13.Ji PF, Yao CL*, Wang ZY, 2011. Reactive oxygen system plays important role in shrimp (Litopenaeus vannamei) defense against Vibrio parahaemolyticus and WSSV infection. Dis Aquat Organ. 96(1):9-20. doi:10.3354/dao02373
14.Ji PF, Yao CL*, Wang ZY, 2011. Two types of calmodulin play different roles in Pacific white shrimp (Litopenaeus vannamei) defenses against Vibrio parahaemolyticus and WSSV infection. Fish Shellfish Immunol, 31:260-268. doi:10.1016/j.fsi.2011.05.011
15.Yao CL, Ji PF, Wang ZY, Li F, Xiang JH*, 2010. Molecular cloning and expression of NOS in shrimp, Litopenaeus vannamei. Fish Shellfish Immunol, 28 (3): 453-460. doi:10.1016/j.fsi.2009.12.002
16.Ji PF, Yao CL*, Wang ZY. 2009.Immune response and gene expression in shrimp (Litopenaeus vannamei) hemocytes and hepatopancreas against some pathogen-associated molecular patterns. Fish Shellfish Immunol, 2009, 27(4) 563-570. doi:10.1016/j.fsi.2009.08.001
17.Yao CL, Ji PF, Kong P, Wang ZY, Xiang JH*. 2009. Arginine kinase from Litopenaeus vannamei: cloning, expression, enzymatic properties and interactive pathway. Fish Shellfish Immunol. 26 (3): 553-558. doi:10.1016/j.fsi.2009.02.012.
18.Yao CL，Wu CG, Xiang JH*, et al., 2008. The lysosome and lysozyme response in Chinese shrimp Fenneropenaeus chinensis to Vibrio anguillarum and laminarin stimulation. J Exp Mar Biol Ecol. 363: 124-129. doi:10.1016/j.jembe.2008.06.035
19.Yao CL, Wang AL*, Wang ZY, Wang WN, Sun RY. Purification and Partial Characterization of CuZn Superoxide Dismutase from hemocyte of Oriental prawn, Microbrachium nipponense. Aquaculture. 270: 559-565.doi:10.1016/j.aquaculture.2007.04.068
20.Yao CL, Wu CG, Xiang JH*, Dong B. Molecular cloning and response to laminarin stimulation of arginine kinase in haemolymph in Chinese Shrimp, Fenneropenaeus chinensis.Fish Shellfish Immunol, 19 (4): 317-329. doi:10.1016/j.fsi.2005.01.006.
Reviewer and Editor Experiences
Reviewer:
Research Grant Council of Hongkong (2013, 2014);
National Science Foundation of China (2008-present)
Paper reviewer, PlosOne, Fish & Shellfish Immunology, Marine Biotechnology, Comp Biochem Physiol (Part A), Comp Biochem Physiol (Part B), Mol Bio Rep，Chin J Oceanol Limnol，Chemosphere, Environmental Science and Pollution Research etc.
Guest Editor:
01/2014-12/2014, Special Issue of “Immune Response of Aquatic Organisms to Infection”, Journal of Immunology Research (IF: 2.904)