陈天圣：博士、教授、博士生导师、闽江********
研究领域：鱼类分子育种
单位地址：福建省厦门市集美区印斗路43号，集美大学水产学院，361021
工作电话：**; 工作QQ：
工作邮件：tiansheng.chen@jmu.edu.cn; chentsxm@qq.com;







个人基本情况
陈天圣，男，1977年出生，厦门大学理学学士和硕士，新加坡国立大学博士，新加坡生物医药研究院资深博士后，福建省“闽江****”****，集美大学水产学院教授，博士生导师；原华中农业大学水产学院教授（2013-2020），博士生导师，湖北省楚天****，鱼类遗传育种课题组组长。主要以基因编辑技术进行鱼类的性别分化和抗病毒病基因的功能解析及应用研究。迄今为止，主持国家自然科学基金项目、国家重点基础研究项目子项目、校高层次人才引进项目、学校创新项目、发育生物学平台建设项目、特色学科项目等6项，研究结果在Nucleic Acids Res，Proc Natl Acad Sci USA，Endocrinology，Front Genet, Int J Mol Sci, J Transl Med., J Fish Dis等期刊发表SCI论文30篇，SCI引用1900多次，授权国内外发明专利4项。参加国内外学术会议及研究院校的口头报告40余次；已经或正在培养的博士和硕士30余名；主讲本科生课程《鱼类发育生物学》、《科研训练：科技论文写作》；担任中国水产学会会员；曾任国际膜外囊泡杂志编委（Journal of Extracellular Vesicles）、国际干细胞协会副会员、新加坡干细胞协会会员、国际膜外囊泡协会会员等。

科研项目
1. 2020年集美大学高层次人才启动经费；
2. 2017年国家自然科学基金面上项目，青鳉母源性pax6b基因调控原生殖细胞迁移的分子机理研究(**)；
3. 2013年科技部国家重点基础研究发展计划子项目（2013CB967700），利用多能干细胞进行感光细胞定向分化和视觉修复的研究；
4. 2015年华中农业大学创新项目，睡美人转座子介导的高效转基因技术在三种大宗淡水鱼的研究（**PY049）；
5. 2014年华中农业大学高层次引进人才项目和水产学院发育生物学平台项目；
6. 2016年合作参与国家自然科学基金面上项目，中华鲟生殖相关细胞系的建立及对温度应激的机理研究(**)；

发表的部分论文（按通讯作者*、第一作者、参与作者）
1. Yizhou Wang，Ting Xue，Qian Wang，Bilin Xia，Qihua Pan，Tiansheng Chen*. Virus susceptibility of a new cell line derived from the fin of black carp Mylopharyngodon piceus. J Fish Biol. 2019;1–9. doi.org/10.1111/jfb.14215；
2. Xueshu Zhang, Xiaoyan Xu, Yubang Shen, Yuan Fang, Jiahua Zhang, Yulin Bai, Shuting Gu, Rongquan Wang, Tiansheng Chen*, JIali Li*. Myeloid differentiation factor 88 (Myd88) is involved in the innate immunity of black carp (Mylopharyngodon piceus) defense against pathogen infection Author links open overlay panel. Fish Shellfish Immunol. 2019; 94:220-229. doi: 10.1016/j.fsi.2019.09.011. Epub 2019 Sep 5；
3. Fangfang Bian, Xuefen Yang, Zhijie Ou, Junzhi Luo, Bozhen Tan, Mingrui Yuan, Tiansheng Chen*, Ruibin Yang*. Morphological Characteristics and Comparative Transcriptome Analysis of Three Different Phenotypes of Pristella maxillaris. Front Genet. 2019 Aug 2;10:698. doi: 10.3389/fgene.2019.00698. eCollection 2019；
4. Qihua Pan, Ting Xue, Bilin Xia, Junzhi Luo, Qian Wang, Yuewen Jiang, Miao Yu, Tiansheng Chen*. Gonadal, Not Maternal, Acquisition of Duplicated pax6 Orthologs in Megalobrama Amblycephala. Int J Mol Sci.2019,20(7), 1710;doi.org/10.3390/ijms**；
5. Yu Deng, Qian Wang, Yizhou Wang, Ting Xue, Junzhi Luo, TianSheng Chen*. Establishment and application of a cell line from medaka (Oryzias latipes) muscle with higher transfection efficiency. Acta Hydrobiol Sin, 2019,43(2), 322-329，doi: 10.7541/2019.040；
6. Qian Wang, Jian Fang, Qihua Pan, Yizhou Wang, Ting Xue, Lingyu Li, Tiansheng Chen*. Efficient and Stable Delivery of Multiple Genes to Fish Cells by a Modified Recombinant Baculovirus System. Int J Mol Sci; 2018,19,3767. doi:10.3390/ijms**；
7. Jian Fang, TianSheng Chen*, Qihua Pan, Qian Wang. Generation of albino medaka (Oryzias latipes) by CRISPR/Cas9. JEZ Part B: Mol Dev Evol, 2018, 330 (4) :242-246. doi:10.1002/jez.b.22808；
8. Ting Xue, Yizhou Wang, Qihua Pan, Qian Wang, Junfa Yuan, Tiansheng Chen*. Establishment of a Cell Line from the Kidney of Black Carp and Its Susceptibility to Spring Viremia of Carp Virus. J Fish Dis, 2018;41(2):365-374. doi: 10.1111/jfd.12736；
9. Miao Yu, Ting Xue, Tiansheng Chen*, Jian Fang, Qihua Pan,Yu Deng, Lingyu Li, Kai Chen, Yizhou Wang. Maternal inheritance of Nanog ortholog in blunt-snout bream, JEZ Part B: Mol Dev Evol, 2017 Dec;328(8):749-759. doi: 10.1002/jez.b.22760；
10. Tiansheng Chen*, Benzion Cavari,Manfred Schartl, Yunhan Hong*. Identification and Expression of Conserved and Novel RNA Variants of Medaka pax6b Gene. JEZ Part B: Mol Dev Evol, 2017, 328(5): 412-422. doi: 10.1002/jez.b.22742；
11. Ting Xue, Miao Yu, Qihua Pan, Yizhou Wan, Jian Fang, Lingyu Li,Yu Deng,Kai Chen,Qian Wang, Tiansheng Chen*. Black carp vasa identifies embryonic and gonadal germ cells. Dev Genes Evol, 2017, 227(4): 231-243. doi: 10.1007/s00427-017-0583-6；
12. TianSheng Chen*, Ronne Wee Yeh Yeo, Fatih Arslan, Yijun Yin, Soon Sim Tan, Ruenn Chai Lai, Andre Choo, Jayanthi Padmanabhan, Chuen Neng Lee, Dominique P.V. de Kleijn, Kok Hian Tan, Sai Kiang Lim*. Efficiency of exosome production underpins the inverse correlation between MSC donor age and efficacy. J Stem Cell Res Ther. 2013, 3: 145. doi: 10.4172/2157-7633.**；
13. TianSheng Chen, Fatih Arslan, Yijun Yin, Soon Sim Tan, Ruenn Chai Lai, Andre Choo, Chuen Neng Lee, Dominique P.V. de Kleijn, Sai Kiang Lim*. Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. J Transl Med. 2011; 9: 47-57. doi: 10.1186/1479-5876-9-47；
14. TianSheng Chen, Ruenn Chai Lai, May May Lee, Andre Choo, Chuen Neng Lee, Sai Kiang Lim*. Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs. Nucl Acids Res. 2010; 38 (1): 215–224. doi: 10.1093/nar/gkp857；
15. TianSheng Chen#, Soon Sim Tan#, Ronne Wee Yeh Yeo#, Bao Ju Teh, Ruihua Luo, GuoDong Li, and Sai Kiang Lim*. Delineating biological pathways unique to embryonic stem cell-derived insulin-producing cell lines from their non-insulin-producing progenitor cell lines. Endocrinology. 2010; 150（8）：3600-3610. doi: 10.1210/en.2009-1418；
16. Xuefen Yang, Haiping Liu,Zhihong Ma,Yu Zou,Ming Zou,Youzhi Mao, Xiaomei Li,Huan Wang, Tiansheng Chen, Weimin Wang, Ruibin Yang. Chromosome‐level genome assembly of Triplophysa tibetana,a fish adapted to the harsh high‐altitude environment of the Tibetan Plateau. Mol Ecol Resour. 2019; 00:1–10. doi: 10.1111/1755-0998.13021；
17. Chun-Xiao Huang, Yan Huang, Xue-Ke Duan, Mu Zhang, Jia-Peng Tu, Jing-Xia Liu, Hong Liu, TianSheng Chen, Wei-Min Wang & Huan-Ling Wang*. Zebrafish miR-462-731 regulates hematopoietic specification and pu.1-dependent primitive myelopoiesis. Cell Death Differ. 2019 26, 1531–1544. doi: 10.1038/s41418-018-0234-0 (Online)；
18. Xiao J, Yan C, Zhou W, Li J, Wu H, TianSheng Chen, Feng H. CARD and TM of MAVS of black carp play the key role in its self-association and antiviral ability. Fish Shellfish Immunol. 2017 Apr; 63:261-269. doi: 10.1016/j.fsi.2017.02.023. Epub 2017 Feb 21；
19. HongMei Wang, JunHong Dong, Qing Li, Qiaoxia Hu, ShangLei Ning, Wenshuai Zheng, Min Cui, TianSheng Chen, Xin Xie, JinPeng Sun*, Xiao Yu *. A stress response pathway upregulates somatostatin level and transcription in pancreatic delta-cells through Gs and β-arrestin1. Diabetologia, 2014,57(9): 1899-1910. dio:10.1007/s00125-014-3290-0；
20. Ruenn Chai Lai, TianSheng Chen, Sai Kiang Lim*. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen. Med. 2011; 6(4): 481–492. 10.2217/rme.11.35；
21. Yan Yan, Tiansu Wang, Tiansheng Chen, Mingyou Li, Ni Hong, Guijun Guan, Songlin Chen, Manfred Schartl, Chang-Ming Li*; Yunhan Hong*. P53 gene targeting by homologous recombination in medakafish ES cells. Plosone 2013; 8(3): doi: 10.1371/journal.pone.**；
22. Guijun Guan, Yan Yan, Tiansheng Chen, Meisheng Yi, Hong Ni, Kiyoshi Naruse, Yoshitaka Nagahama, Yunhan Hong*. Nanos3 Gene Targeting in Medaka ES Cells. Int J Biol Sci 2013; 9(5):444-454. doi: 10.7150/ijbs.6507；