解丽娟联系电话：** 邮箱：xielijuan@hqu.edu.cn
华侨大学医学院副研究员
本科毕业于华东理工大学化学制药专业
研究生（硕博）就读于大连理工大学精细化工国家重点实验室应用化学专业
先后在香港中文大学和美国德州大学奥斯丁分校作访问****

研究方向
1.抗肿瘤药物 针对乳腺癌、白血病等恶性肿瘤的化合物的设计、合成及生物活性研究
2.细胞器靶向荧光探针研究


主持课题
1.抑制白血病细胞生长的萘酰亚胺类化合物的研究。泉州市科技计划项目，项目编号2019C033R
2.氨萘非特增效、减毒新方法的研究。福建省科技厅社会发展重点项目，项目编号2013Y0066
3.聚乙二醇修饰的氨萘非特作为抗肿瘤药物的研究。侨办课题，项目编号11J0277
4.对神经细胞内钙离子和一氧化氮进行同步检测的荧光探针。大连理工大学精细化工国家重点实验室开放课题，项目编号KF0901
5.含有1，8-萘酰亚胺单体的聚乙烯亚胺类非病毒基因载体的研究。华南肿瘤学国家重点实验室开放课题，2009.8-2011.7
6.5-位芳香基团取代的萘酰亚胺类化 合物的设计、合成及生物活性研究。项目编号09Y0142

此外参与两项国家自然基金课题研究

发表文章及专利
1.1 Jinfeng Yu,Hui Bian, Huizi Man, Ning Li, Lijuan Xie,*, Yi Xiao,**Two–photon excitable red fluorophores for imaging living cells.Dyes and Pigments,2018, 149,851–857
1.2解丽娟*,陈卓.类呋喃香豆素的合成与DNA的结合及细胞毒性研究.光谱学与光谱分析,2014，34（11），3051-3055 .SCI收录
1.3解丽娟*，李建民. 7-二乙胺基-3-(2’-吡啶)香豆素的新用途:溶酶体荧光探针.发光学报, 2013, 34(11), 1538-1543.EI收录
1.4Yinghui Chen, Jianzhang Zhao,Lijuan Xie, Huimin Guo, Qiuting Li. Thienyl-substituted BODIPYs with strong visible light-absorption and long-lived triplet excited states as organic triplet sensitizers for triplet–triplet annihilation upconversion.RSC Adv., 2012, 2, 3942-3953.
1.5Yinghui Chen, Jianzhang Zhao, Huimin Guo, Lijuan Xie. Geometry Relaxation-Induced Large Stokes Shift in Red-Emitting Borondipyrromethenes (BODIPY) and Applications in Fluorescent Thiol Probes.J. Org. Chem., 2012, 77(5), 2192–2206.
1.6Lijuan Xie*, Yinghui Chen, Wenting Wu, Huimin Guo, Jianzhang Zhao, Xuerong Yu. Fluorescent coumarin derivatives with large stokes shift, dual emission and solid state luminescent properties: An experimental and theoretical study.Dyes and Pigments,2012, 92, 1361-1369.
1.7Xu Ke; Liang Xin; Wang Fang; Xie Lijuan; Xu Yufang; Liu Jianwen; Qian Xuhong. Induction of G(2)/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells. ANTI-CANCER DRUGS.,2011, 22 (9),875-885.
1.8Lijuan Xie, Jingnan Cui, Xuhong Qian, Yufang Xu, Jianwen Liu, R.A.Xu. 5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior. Bioorganic & Medicinal Chemistry,2011; 19 (2), 961-967.
1.9Li-juanXie*, 5-Butylamino-2-[2-(dimethylamino)-ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione.Acta
Crystallographica Section E, 2010, E66, O1454-U1788
1.10Lijuan Xie,Yi Xiao, Fang Wang, Jianwen Liu, Yufang Xu, Xuhong Qian, Jingnan Cui. Rong Zhang.
Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity,DNA-binding and cell
cycle evaluation. Bioorganic & Medicinal Chemistry, 2009, 17, 7615–7621.
1.11Kewei Wang, Jingnan Cui, Lijuan Xie,Xuhong Qian.Design, synthesis, and Evaluation of Unsymmetrical Difluoro-Boron Complexes with Imidazoline as Potential Fungicides. Heteroatom Chemistry,2009,20 (7), 418-424.
1.12Lijuan Xie, Yufang Xu, Fang Wang, Jianwen Liu, Xuhong Qian, Jingnan Cui. Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies. Bioorganic & Medicinal Chemistry, 2009,16, 804-810.
1.13Lijuan Xie,Xuhong Qian, Jingnan Cui, Yi Xiao, Kewei Wang, Peichun Wu, Liying Cong. Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies. Bioorganic & Medicinal Chemistry, 2008, 16, 8713-8718.
2.12解丽娟(共同专利发明人，第1位)“酰亚胺位或4-位取代的1，8-萘酰亚胺衍生物作为PARP抑制剂的用途”。CN2.3
2.13解丽娟(发明人，第1位)“一类萘酰亚胺双光子荧光染料、其制备方法和应用”。CN0.6
作为共同专利发明人共获得授权专利十三项