基本信息：
马俊杰，博士，华侨大学医学院，副教授，硕士生导师
电话：/**
邮箱：majunjie3612@hqu.edu.cn

学习与工作经历：
2020/01-至今，华侨大学，医学院，副教授
2015/07－2019/12，华侨大学，医学院，讲师
2012/09－2015/06，沈阳药科大学，药物化学专业博士

主要研究方向：
1、药物化学—基于靶点的药物设计与评价
2、药物合成研究与开发

主持、参与的科研项目：
1、国家自然科学青年基金，**，新型小分子procaspase3变构激活剂的分子构建和抗肿瘤活性评价，17.30万元，主持。
2、福建省自然科学基金面上项目，2017J01143，procaspase-3激动剂的设计、合成以及抗肿瘤活性研究，6万，主持。
3、华侨大学中青年教师科技创新资助计划，ZQN-PY519，PD-1/PD-L1免疫检查点小分子抑制剂的设计与评价，40万，主持。
4、华侨大学科研启动基金，15BS415，基于2羟基苯甲醛缩氨基脲结构的分子构建和抗肿瘤活性评价，4万元，主持。
5、泉州市科技项目，2018C074R，免疫检查点PD-1/PD-L1小分子抑制剂的研发，20万，主持。
6、国家自然科学面上项目，**，靶向抑制RhoA蛋白的二萜化合物curcusoneA的抗肿瘤构效关系、结构优化和分子机制研究，60万，参与。

发表论文：
(1) Junjie Ma^*, Xin Ni, Yali Gao, Kun Huang, Jiaan liu, Yu Wang, Roufen Chen, Cuifang Wang^*. Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers via activation of procaspase-3 to caspase-3, MedChemComm, 2019, 10(3), 465-477.
(2) Junjie Ma^*, Xin Ni, Yali Gao, Kun Huang, Yu Wang, Jiaan Liu, Guowei Gong^*. Semicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, Chemical & Pharmaceutical Bulletin, 2019, 67(4), 351-360.
(3) Junjie Ma^*, Kun Huang, Xin Ni, Roufen Chen, Boxuan Xu & Cuifang Wang^*. Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-Methyl-Biphenyl Moiety, Chem. Res. Chinese Universities, 2019, 35, 410-417.
(4) Shao, Jiang-Yang; Wu, Si-Hai; Ma, Junjie; Gong, Zhong-Liang; Sun, Tian-Ge; Jin, Yulong; Yang, Rong; Sun, Bin; Zhong, Yu-Wu. Ratiometric detection of amyloid-beta aggregation by a dual-emissive tris-heteroleptic ruthenium complex, Chem. Commun., 2020, 56, 2087-2090.
(5) Ming-Ze Qin, Lei Wang, Shuang Yan,Jun-Jie Ma, YeTian, Yan-Fang Zhao, Ping Gong. Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells, Chinese Chemical Letters,2017,28(5), 991-994.
(6) 马俊杰^*, 倪欣, 黄坤, 王瑜,含苯并噻唑/苯基片段的香豆素衍生物的设计、合成及抗肿瘤活性研究,Acta Pharmaceutica Sinica(药学学报), 2019, 54(3), 514 ?521.
(7) 倪欣,黄坤,马俊杰^*. Procaspase-3 小分子激活剂的研究进展,中国现代应用药学,2019, 36(3), 368-371.
(8) 朱玉垚,黄坤,王瑜,马俊杰^*. HDAC多靶点抑制剂在癌症治疗中的研究进展,聊城大学学报(自然科学版),2019,32(05), 71-79.
(9)Junjie Ma, Guanglong Bao, Limei Wang, Wanting Li, Boxuan Xu, XinZhai, Ping Gong^*. Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole-based moiety as potent antitumor agents, European Journal of Medicinal Chemistry, 2015, 96, 173-186.
(10)MA Junjie, HU Gang, XIE Lijun, CHEN Lei, XU Boxuan, GONG Ping^*. Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents, Chemical Research in Chinese Universities, 2015, 31(6), 958-963.
(11) Junjie Ma, Dong Chen, Kuan Lu, Lihui Wang, Xiaoqi Han, Yanfang Zhao, Ping Gong^*. Design, synthesis, and structureeactivity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents, European Journal of Medicinal Chemistry, 2014, 86, 257-269.
(12) Junjie Ma, Guangyan Zhang, Xiaoqi Han, Guanglong Bao, Lihui Wang, Xin Zhai,and Ping Gong^*. Synthesis and Biological Evaluation of Benzothiazole Derivatives Bearing the ortho-Hydroxy-N-acylhydrazone Moiety as Potent Antitumor Agents, Arch. Pharm. Chem. Life Sci, 2014, 347(12), 936-949.
(13) SONG Kaizhen, MA Junjie, WANG Xiao, GONG Ping^*, ZHAO Yanfang*. Synthesis and Antitumor Activities of Novel 4-Morpholinothieno[3,2-d] pyrimidineDerivatives, ChemicalResearchinChineseUniversities, 2014, 30(1), 75-81.
(14) Mingze Qin, Xin Zhai, Hongbo Xie, Junjie Ma, Kuan Lu, Yu Wang, Lihui Wang, Yucheng Gu and Ping Gong^*. Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazole-3-yl)pyridines as potentialantitumoragents, European Journal of Medicinal Chemistry, 2014,81, 47-58.
(15) 马俊杰,宫平*,二巯丁二酸.中国药物化学杂志,2014,4 (5): 419-419.
(16) 马俊杰,宫平*,Technetium 99mTc tilmanocept.中国药物化学杂志,2013,23(5),422-422.

专利：
1. 马俊杰,倪欣,黄坤,王翠芳. 一种用作caspase-3激活剂的香豆素类衍生物及其应用,CN .
2. 马俊杰,黄坤,倪欣,陈柔棻,余楚丹,闫琦慧,陈思颖,侯晓林. 一种用作caspase-3激活剂的缩氨基脲类衍生物及其应用,CN .
3. 马俊杰,黄坤,倪欣,陈柔棻,余楚丹,闫琦慧,陈思颖,侯晓林. 一种香豆素类衍生物及其应用,CN .　
4.宫平,翟鑫,赵燕芳,刘亚婧,马俊杰.缩氨基脲衍生物及其用途，中国，ZL9.2.