罗小华
学术学位硕士生导师

副教授



xiaohua-luo@163.com

第一临床学院





学科信息


个人简介
罗小华，男，重庆医科大学附属第一医院血液内科，医学博士，副教授，副主任医师，副研究员，硕士生导师。国家公派访问****。第四批重庆市中青年医学高端人才。
2009年博士毕业于北京大学医学部，2016年留学瑞典Karolinska Institutet。主要研究方向为造血干细胞移植和免疫治疗。主持国家自然科学基金面上和青年项目、国际合作项目、重庆市卫计委项目等课题。在国内外杂志发表论文30余篇和授权实用新型专利1项。担任JCV、TID、重庆医科大学学报等杂志审稿专家。兼任中华医学会血液学分会感染学组委员、中国抗癌协会血液肿瘤专委会青年委员和重庆市医学会血液学专业委员会青年委员。系欧洲血液病学会、美国免疫学会以及中国免疫学会会员。




科研项目
1. 重庆市留创计划项目，cx**，造血干细胞移植后CMV感染CD8+ T细胞亚群的致病力研究，在研，主持
2. 国家自然科学基金委员会，面上项目，**，SPAG6介导PTEN及p53启动子甲基化在MDS发病中的机制研究，在研，参与
3. 重庆市科卫联合医学科研项目，2019GDRC004，靶向Mesothelin的CART细胞治疗CBF+AML的临床前研究，在研，主持
4. 重庆市留创计划项目，**，CMV特异性T细胞调控急性髓系白血病骨髓免疫微环境，在研，主持
5. 国家自然科学基金面上项目，**，SPAG6与MDS细胞凋亡的关系及机制研究，已结题，参加
6. 国家自然科学基金面上项目，**，造血干细胞移植后CMV感染介导抗白血病效应：基于IL-12/IFN-γ炎症轴调控T-bet/Eomes平衡的机制研究，已结题，主持
7. 重庆市卫生计生委医学科研项目，**，G-CSF动员的单倍体供者T淋巴细胞诱导抗巨细胞病毒效应的应用研究，已结题，主持
8. 国家自然科学基金青年基金项目，**，WASp在异基因造血干细胞移植后巨细胞病毒特异性T细胞免疫重建中的机制研究，已结题，主持
9. 重庆市医学科研计划项目，2011-2-208，IL-15及IL-15Rα与儿童急性淋巴细胞白血病微小残留病关系的研究，已结题，主持



论文情况


1. Mao J, Dai R, Du RC, Zhu Y, Shui LP, Luo XH*. Hematologic changes predict clinical outcome in recovered patients with COVID-19. Annals of hematology. 2021 Feb 1:1-5.
2. Luo XH*, Zhu Y, Mao J, Du RC. T cell immunobiology and cytokine storm of COVID‐19. Scandinavian Journal of Immunology. 2021 Mar;93(3):e12989.
3.Luo XH, Zhu Y, Shui LP, Xiao Q, Liu L. Repeated ruptures of corpus luteum in a female patient with alpha1-antitrypsin Pittsburgh. Annals of Hematology. 2020 Nov 6:1-4.
4.Li JN, Zhu Y, Zhan Q, Wang L, Liu L, Luo XH*. Myeloproliferative neoplasm with BCR/ABL and JAK2 mutation: A case report and literature review. Medical Journal of Chinese People's Liberation Army. 2020 Jul 28;45(7):757-60.
5. Luo XH*, Meng Q, Liu Z, Paraschoudi G. Generation of high-affinity CMV-specific T cells for adoptive immunotherapy using IL-2, IL-15, and IL-21. Clinical Immunology. 2020 May 5:108456.
6. Li S, Huang J, Zhang YL, Zhu Y, An YF, Du J, Zhang ZL, Xia Y, Liu L, Wang L, Luo XH*. Wiskott-Aldrich syndrome protein may be critical for CD8+ T cell function following MCMV infection. Cellular immunology. 2019 Apr 1;338:43-50.
7. Zhang YL, Zhu Y, Xiao Q, Wang L, Liu L, Luo XH*. Cytomegalovirus infection is associated with AML relapse after allo-HSCT: a meta-analysis of observational studies. Annals of hematology. 2019 Jan 21:1-12.
8.夏瑜, 张在利, 李莎, 詹茜, 肖青, 王利, 刘林, 罗小华*. 外周血干细胞采集物来源的巨细胞病毒特异性 T 细胞的体外培养和扩增. 细胞与分子免疫学杂志. 2019(1):13.
9. Luo XH, Meng Q, Rao M, Liu Z, Paraschoudi G, Dodoo E, Maeurer M. The impact of inflationary cytomegalovirus‐specific memory T cells on anti‐tumour immune responses in patients with cancer. Immunology. 2018 Nov;155(3):294-308.
10.Wang Q, Zhu Y, Li D, Xiao Q, Wang L, Liu L, Luo XH*. Concurrent mucosa-associated lymphoid tissue lymphoma with diffuse large B-cell lymphoma transformation and Hodgkin lymphoma of the neck. Annals of hematology. 2018 Jun 1;97(6):1089-94
11.张在利, 朱艳, 李莎, 杜鹃, 夏瑜, 肖青, 王利, 刘林, 罗小华*. MCMV 诱导鼠T细胞淋巴瘤EL4细胞凋亡及其作用机制. 中国实验血液学杂志. 2018(4):28.
12.李莎, 朱艳, 张在利, 詹茜, 夏瑜, 杜鹃, 张玉琳, 王利, 刘林, 罗小华*. MCMV 早期感染对小鼠 CD8+ T, γδT 和 NK 细胞功能的影响. 免疫学杂志. 2018;34(8):645-57.
13.Liu Z, Poiret T, Persson O, Meng Q, Rane L, Bartek J, Karbach J, Altmannsberger HM, Illies C, Luo X, Harvey-Peredo I. NY-ESO-1-and survivin-specific T-cell responses in the peripheral blood from patients with glioma. Cancer Immunology, Immunotherapy. 2018 Feb 1;67(2):237-46.
14. Liu Zhenjiang, Martin Rao, Xiaohua Luo, Elisabeth Sandberg, Jiri Bartek Jr, Esther Schoutrop, Anna von Landenberg, Qingda Meng, Davide Valentini, Thomas Poiret, Georges Sinclair, Inti-Harvey Peredo, Ernest Dodoo, and Markus Maeurer*. Mesothelin-specific Immune Responses Predict Survival of Patients With Brain Metastasis. EBioMedicine. 2017 Sep; 23: 20–24
15.Zhenjiang L, Rao M, Luo X, Valentini D, von Landenberg A, Meng Q, Sinclair G, Hoffmann N, Karbach J, Altmannsberger HM, J？ger E. Cytokine Networks and Survivin Peptide-Specific Cellular Immune Responses Predict Improved Survival in Patients With Glioblastoma Multiforme. EBioMedicine. 2018 Jul 1;33:49-56.
16.Poiret T, Axelsson-Robertson R, Remberger M, Luo XH, Rao M, Nagchowdhury A, Von Landenberg A, Ernberg I, Ringden O, Maeurer M. Cytomegalovirus-Specific CD8+ T-Cells With Different T-Cell Receptor Affinities Segregate T-Cell Phenotypes and Correlate With Chronic Graft-Versus-Host Disease in Patients Post-Hematopoietic Stem Cell Transplantation. Frontiers in immunology. 2018 Apr 10;9:760.
17. Liu Z, Meng Q, Bartek Jr J, Poiret T, Persson O, Rane L, Rangelova E, Illies C, Peredo IH, Luo X, Rao MV. Tumor-infiltrating lymphocytes (TILs) from patients with glioma. Oncoimmunology. 2017 Feb 1;6(2):e**.
18.Yang, B. H., Zhu, Y., Du, J., Zhang, Y. L., Li, S., Liu, L., & Luo, X. H*. Paraplegia as Manifestation of an Isolated Central Nervous System Relapse Following Allogeneic Hematopoietic Stem Cell Transplantation in a Woman with Acute Myelogenous Leukemia. Chinese Medical Journal 2016, 129(18), 2260.
19.Du, J., Zhu, Y., Zhang, Y. L., Li, S., Huang, J., Luo, X. H*., & Liu, L*. Heart failure and pulmonary arteriovenous malformations in a patient with hereditary hemorrhagic telangiectasia type 2. Journal of Thrombosis and Thrombolysis 2015, 40(4), 515-519.
20.朱艳, 罗小华*, 李招权, 刘林. 以类白血病反应高钙血症和深静脉血栓为主要表现的皮肤鳞状细胞癌 1 例报告并文献复习. 中国实用内科杂志. 2015;35(7):638-40
21.Xiao-Hua Luo, Ying-Jun Chang, Xiao-Jun Huang*. Improving cytomegalovirus specific T cell reconstitution after haploidentical stem cell transplantation. Journal of Immunology Research 2014 (2014).
22. Xiao-Hua Luo, Yan Zhu, and Xiao-Qiong Tang*. Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report. Oncology Letters 2014, 8(4), 2513-2516.
23.张玉琳, 罗小华*, 刘林. WAS 基因缺陷小鼠 MCMV 急性感染模型的建立及感染特点. 第三军医大学学报. 2014 Oct 15;36(19).
24.黄婧, 罗小华*, 朱艳, 王利, 刘林. 多发性骨髓瘤伴原发性血小板增多症一例报告并文献复习. 中华血液学杂志. 2014;35(008):757-9
25.Xiao-Hua Luo, Xiao-Jun Huang*, Dan Li, Kai-Yan Liu, Lan-Ping Xu, Dai-Hong Liu. Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact of in vivo T-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood/bone marrow mixed grafts. Transplant Infectious Disease 2013; 15(1):22-33
26.罗小华, 常英军, 霍明瑞, 李丹, 黄晓军*. 同胞HLA全相合骨髓和外周血造血干细胞混合移植后血液病患者 CMV 特异性T细胞免疫重建规律. 中华血液学杂志. 2012; 33(8), 605-609
27.XH Luo, XJ Huang*, KY Liu, LP Xu, DH Liu. Protective immunity transferred by infusion of CMV-specific CD8+ T cells within donor grafts: its associations with CMV reactivation following unmanipulated allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2010; 16(7):994-1004
28.XH Luo, YJ Chang, LP Xu, DH Liu, KY Liu, XJ Huang*. The impact of graft composition on clinical outcomes in unmanipulated HLA-mismatched/haploidentical haematopoietic SCT. Bone Marrow Transplant 2009; 43(1):29-36.
29. Lan-Ping Xu, Xiao-Hua Luo, Ying-Jun Chang, Dai-Hong Liu, Kai-Yan Liu, Yu-Hong Chen, Xiao-Jun Huang*. Lower CD4/CD8 ratio in allografts may predict better clinical outcomes after unmanipulated HLA-mismatched/haploidentical haematopoietic stem cell transplantation for chronic myeloid leukemia. Ann Hematol 2009; 88(10): 1015-1024.










研究方向
造血干细胞移植和免疫治疗