童超
学术学位硕士生导师

副研究员



chaotongcqmu@163.com

第一临床学院





学科信息


个人简介


纽约州立大学（SUNY-Buffalo)药理学博士，匹兹堡大学博士后。现任国家自然科学基金委医学部流动编制项目主任，重庆医科大学附属第一医院产科副研究员，硕士生导师, 新西兰奥克兰大学Liggins研究所名誉研究员。人力资源与社会保障部高层次留学人才回国资助人选，重庆市海外高层次引进人才，重庆市中青年医学高端后备人才，入选首批重庆英才计划青年拔尖人才项目，以及重庆市留学人员归国创新创业支持计划。主要从事生殖发育与重大妊娠疾病的分子机制和临床转化研究，以及不良宫内环境对子代健康的远期影响及机制研究。近年来发表SCI论文70余篇，担任国家自然科学基金项目评审专家及十余种SCI期刊编委与审稿专家。主持国家自然科学基金项目4项，国际合作项目3项，省部级项目4项，另作为学术骨干参与国家重点研发计划、国家自然科学基金国际(地区)合作重点项目等国家级课题15项，承担科研经费超600万元。





科研项目
课题名称：合胞滋养细胞Neprilysin经细胞外囊泡转运调控母体外周血管内皮细胞与平滑肌细胞间对话的机制研究
资助机构：国家自然科学基金委员会
项目批准号：**
项目金额：55万元
资助年限：2021.1-2024.12
主持
课题名称：基于双胎出生队列研究喂养方式及营养摄入对新生儿一周岁龄生长发育的影响
资助机构：北京大学
项目金额：1.5万元
资助年限：2020.11-2021.10
主持
课题名称：Establishment of non-human primate preeclampsia model
资助机构：辉凌生殖健康研究所（中国科学院动物所－瑞士Ferring制药）
项目金额：91万元
资助年限：2020.5-2022.5
主持
课题名称：妊娠糖尿病对母乳成分及母乳喂养结局的影响研究
资助机构：重庆市卫生健康委员会 (重庆市科卫联合医学科研项目)
项目批准号：2019GDRC012
项目金额：16万元
资助年限：2019.8-2022.8
主持
课题名称：AMPK调控内皮祖细胞参与子宫－胎盘循环建立在子痫前期发生中的作用及机制研究
资助机构：国家自然科学基金委员会
项目批准号：**
项目金额：57万元
资助年限：2019.1-2022.12
主持
课题名称：AMPK-related metabolic reprogramming: new target for preeclampsia treatment?
资助机构：辉凌生殖健康研究所（中国科学院动物所－瑞士Ferring制药）
项目金额：250万元
资助年限：2018.12-2023.12
主持
课题名称：选择性胎儿宫内生长受限的代谢调控网络
资助机构：国家卫生计生委出生缺陷与生殖健康重点实验室
项目批准号：2018-5
项目金额：6万元
资助年限：2018.10-2021.9
主持

重大胎儿疾病宫内诊断和治疗新技术开发国家重点研发计划
课题名称：重大胎儿疾病临床研究队列以及宫内诊断与干预技术平台的建立
资助机构：国家科技部
课题编号：2018YFC**
项目金额：320万元（个人承担55万元）
资助年限：2018.7-2020.12
学术骨干
课题名称：高龄妊娠的胎盘衰老机制及防治策略
资助机构：重庆市科学技术委员会
项目批准号：cstc2017jcyjBX0045
项目金额：20万元
资助年限：2017.6-2021.12
主持
课题名称：AMPK经NET1A调控RhoA-ROCKII通路介导的滋养细胞侵袭相关机制研究
资助机构：国家自然科学基金委员会
项目批准号：**
项目金额：60万元
资助年限：2017.1-2020.12
主持
课题名称：AMPK参与子痫前期发生的机制研究
资助机构：重庆市教育委员会
项目编号：KJ**
项目金额：2万元
资助年限：2015.9-2017.9
主持
课题名称：AMPK介导肥胖相关子痫前期风险的机制研究
资助机构：重庆医科大学
项目编号：CYYQ201507
项目金额：10万元
资助年限：2015.11-2017.11
主持
课题名称：抑制11beta-HSD1通过RAS通路而缓解1型糖尿病肾病的机制研究
资助机构：国家自然科学基金委员会
项目批准号：**
项目金额：23万元
资助年限：2014.1-2016.12
主持
生殖健康及重大出生缺陷防控研究国家重点研发计划
课题名称：中国高龄孕妇早产防治策略和发生机制研究
资助机构：国家科技部
课题编号：2016YFC**
项目金额：320万元
资助年限：2016.7-2020.12
参与
课题名称：双胎妊娠队列研究：探究生命早期基因环境复杂的交互作用，及其在婴幼儿相关疾病早期预测中的作用
资助机构：国家自然科学基金委员会
项目批准号：
项目金额：235万元
资助年限：2016.1-2020.12
参与



论文情况
1.Xiong L^#, Ye X^#, Chen Z, Fu H, Li S, Xu P, Yu J, Wen L, Gao R, Fu Y, Qi H*, Kilby MD, Saffery R, Baker PN, Tong C*. Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial?Mesenchymal Transition through an Increase in Vimentin Acetylation. Aging Cell. 2021. In press. IF=9.304
2. Jin H^#, Shan T^#, Li S^#, Fan X, Zhao Y, Li J, Tang X, Saffery R, Tong C*, Wen L*, Qi H*, Kilby MD, Baker PN. Association of infant feeding patterns with body fat mass and obesity in the first 2 years of life: a longitudinal twin birth cohort study. Int J Food Sci Nutr. 2021 Aug 19:1-11. doi: 10.1080/**.2021.**. Online ahead of print. PMID: ** IF=3.713
3. Chen Z^#, Xiong L^#, Jin H^#, Yu J, Li X, Fu H, Wen L, Qi H*, Tong C*, Saffery R, Kilby MD, Baker PN. Advanced maternal age causes premature placental senescence and malformation via dysregulated α-Klotho expression in trophoblasts. Aging Cell. 2021. e13417. doi: 10.1111/acel.13417. IF=9.304
4. Yu J^#, Jin H^#, Wen L^#, Zhang W, Saffery R, Tong C*, Qi H*, Kilby MD, Baker PN. Insufficient Sleep During Infancy Is Correlated with Excessive Weight Gain in Childhood: A Longitudinal Twin Cohort Study. J Clin Sleep Med. 2021. In press. IF=4.062
5. Li X^#, Yu J^#, Wen L^#, Li Q, Yan J, Tian J, Tong C*, Tong Q*, Qi H*, Saffery R, Kilby MD, Baker PN. Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China. BMC Pregnancy Childbirth. 2021. 21(1):279. doi: 10.1186/s12884-021-03707-7. IF=3.007
6. Yang Y^#, Wen L^#, Han TL, Zhang L, Fu H, Gan J, Saffery R, Tong C*, Li J*, Qi H*, Baker PN, Kilby MD. Twin-Twin Transfusion Syndrome Is Associated with Alterations in the Metabolic Profile of Maternal Plasma in Early Gestation: A Pilot Study. Prenat Diagn. 2021 Mar 15. doi: 10.1002/pd.5933. Online ahead of print. IF=3.05
7. Wu Y^#, Yu J^#, Liu X^#, Wang W, Chen Z, Qiao J, Liu X, Jin H, Li X, Wen L, Tian J, Saffery R, Kilby MD, Qi H*, Tong C*, Baker PN. Gestational diabetes mellitus-associated changes in the breast milk metabolome alters the neonatal growth trajectory. Clin Nutr. 2021. 40(6):4043-4054. doi: 10.1016/j.clnu.2021.02.014. IF=7.324
8. Liu X^#, Wang Y^#, Wu Y^#, Zeng J, Yuan X, Tong C*, Qi H*. What we know about placenta accreta spectrum (PAS). Eur J Obstet Gynecol Reprod Biol. 2021; 259:81-89. doi: 10.1016/j.ejogrb.2021.02.001. IF=2.435
9. Hu M, Li J, Baker PN, Tong C*. Revisiting preeclampsia: a metabolic disorder of the placenta. FEBS J. 2021 Feb 2. doi: 10.1111/febs.15745. IF=5.542
10. Mei Y^#, Yu J^#, Wen L^#, Fan X, Zhao Y, Li J, Qiao J, Fu H, Leong P, Saffery R, Tong Q, D Kilby M, Qi H*, Tong C*, Baker PN. Perinatal outcomes and offspring growth profiles in twin pregnancies complicated by gestational diabetes mellitus: a longitudinal cohort study. Diabetes Res Clin Pract. 2021;171:108623.doi:10.1016/j.diabres.2020.108623.IF=5.602
11. Wang H^#, Xu P^#, Luo X^#, Hu M, Liu Y, Yang Y, Peng W, Bai Y, Chen X, Tan B, Wu Y, Wen L, Gao R, Tong C*, Qi H*, Kilby MD, Saffery R, Baker PN. Phosphorylation of YAP Impairs Trophoblast Invasion and Migration: Implications for the Pathogenesis of Fetal Growth Restriction. Biol Reprod. 2020. 103(4):866-879. doi: 10.1093/biolre/ioaa112. IF=4.285
12. Qi H^#*, Chen M^#, Luo X^#, Liu X, Shi Y, Liu T, Zhang H, Zhang J, Zhao Y, Tong C*, Baker PN. Management of a Delivery Suite During the COVID-19 Epidemic. Eur J Obstet Gynecol Reprod Biol. 2020, 250:250-252. doi: 10.1016/j.ejogrb.2020.05.031. IF=2.435
13. Yang Y, Xu P, Zhu F, Liao J, Wu Y, Hu M, Fu H, Qiao J, Lin L, Huang B, Jin H, Liu X, Zheng Y,Wen L, Saffery R, Kilby MD, Yan J, Kenny L, Qi H*, Tong C*, Baker PN. The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy. Antioxid Redox Signal. 2021. 34(2):118-136. doi: 10.1089/ars.2019.7891. IF=8.401
14. Qi H*, Luo X, Zheng Y, Zhang H, Li J, Zou L, Feng L, Chen D, Shi Y, Tong C*, Baker PN. Safe Delivery for COVID-19 Infected Pregnancies. BJOG. 2020, 127(8):927-929. doi: 10.1111/1471-0528.16231.IF=6.531
15. Tian J^#, Liu Y^#, Hu M^#, Zheng Y, Xu P, Zhang L, Liao J, Wu Y, Wen L, Tong C*, Yan J*, Qi H*, Saffery R, Baker PN, Kilby MD. Upregulated LncZBTB39 in pre-eclampsia and its effects on trophoblast invasion and migration via antagonizing the inhibition of miR-210 on THSD7A expression. Eur J Obstet Gynecol Reprod Biol. 2020. 248:164-171. doi: 10.1016/j.ejogrb.2020.03.035. IF=2.435
16. Wen L^#, Ge H^#, Qiao J, Zhang L, Chen X, Kilby MD, Zhou Y, Gan J, Saffery R, Yan J, Tong C*, Qi H*, Baker PN. Maternal dietary patterns and risk of gestational diabetes mellitus in twin pregnancies: a longitudinal twin pregnancies birth cohort study. Nutr J. 2020 Feb 10;19(1):13. doi: 10.1186/s12937-020-00529-9. IF=3.271
17. Zhang L, Liu X, Li J, Wang X, Huang S, Luo X, Zhang H, Wen L, Tong C*, Saffery R, Yan J*, Qi H*, Kilby MD, Baker PN. Maternal Utero-Placental Perfusion Discordance in Monochorionic-Diamniotic Twin Pregnancies with Selective Growth Restriction Assessed by Three-Dimensional Power Doppler Ultrasound. Med Sci Monit. 2020. 26:e919247. doi: 10.12659/MSM.919247. IF=2.649

18. He C^#, Shan N^#, Xu P, Ge H, Yuan Y, Liu Y, Zhang P, Wen L, Zhang F, Xiong L, Peng C, Qi H*, Tong C*, Baker PN. Hypoxia-induced Downregulation of SRC-3 Suppresses Trophoblastic Invasion and Migration Through Inhibition of the AKT/mTOR Pathway: Implications for the Pathogenesis of Preeclampsia. Sci Rep.2019. 9(1):10349. doi: 10.1038/s41598-019-46699-3. IF=3.998
19. Wen L^#, Wu Y^#, Yang Y^#, Han TL^#, Wang W^#, Fu H, Zheng Y, Shan T, Chen J, Xu P, Jin H, Lin L, Liu X, Qi H*, Tong C*, Baker PN. Gestational Diabetes Mellitus Changes the Metabolomes of Human Colostrum, Transition Milk and Mature Milk. Med Sci Monit. 2019. 25:6128-6152. doi: 10.12659/MSM.915827. IF=1.918
20. Wang W^#, Wen L^#, Zhang Y^#, Wang L, Wang L, Chen Z, Zhang L, Zhang C, Li J, Tong C*, Qi H*, Saffery R, Baker PN. Maternal prenatal stress and its effects on primary pregnancy outcomes in twin pregnancies. J Psychosom Obstet Gynaecol. 2019 May 8:1-7. doi: 10.1080/**X.2019.**. IF=2.0
21. Peng W^#, Tong C^#, Li L, Huang C, Ran Y, Chen X, Bai Y, Liu Y, Zhao J, Tan B, Luo X, Wang H, Wen L, Zhang C, Zhang H, Ding Y*, Qi H*, Baker PN. Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia. FASEB J. 2019.33(5):6327-6338. doi: 10.1096/fj.RR.
22. Luo X^#, Zou H^#, Xu P, Wen L, Stanley JL, Jiang X, Han TL, Olson D, Peng C, Zhang C, Xiao X*, Tong C*, Qi H*, Baker PN. Blunted Cardiac AMPK Response is Associated with Susceptibility to Ischemia/Reperfusion in Male Offspring of Gestational Diabetic Rats. Cell Physiol Biochem. 2019;52(5):1103-1116. doi: 10.33594/.
23. Tan B^#, Tong C^#*, Yuan Y, Xu P, Wen L, Zhang C, Zheng Y, Lin L, Zhu F, Gui S, Wang L, Gao R, Li J, Qi H, Baker PN*. The Regulation of Trophoblastic p53 Homeostasis by the p38-Wip1 Feedback Loop is Disturbed in Placentas from Pregnancies Complicated by Preeclampsia. Cell Physiol Biochem. 2019; 52:315-335
24. Wen L, Liu X, Wang L, Zheng Y, Li J, Tong C*, Qi H*, Saffery R, Baker P. Correlation between second trimester weight gain and perinatal outcomes in dichorionic twin pregnancies: The LoTiS cohort study. Eur J Obstet Gynecol Reprod Biol. 2019; 233:64-69.IF=1.868
25. Delplancke TDJ^#, Wu Y^#, Han TL, Joncer LR, Qi H, Tong C*, Baker PN. Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair. Biomed Res Int. 2018; 2018:**. doi: 10.1155/2018/**.
26. Wang L^#, Wen L^#, Zheng Y, Zhou W, Mei L, Li H, Tong C*, Qi H*, Baker PN. Association Between Gestational Weight Gain and Pregnancy Complications or Adverse Delivery Outcomes in Chinese Han Dichorionic Twin Pregnancies: Validation of the Institute of Medicine (IOM) 2009 Guidelines. Med Sci Monit. 2018; 24:8342-8347. doi: 10.12659/MSM.911784.
27. Wang L, Han TL, Luo X, Li S, Young T, Chen C, Wen L, Xu P, Zheng Y, Saffery R, Baker PN, Tong C*, Qi H*. Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue. Sci Rep. 2018; 8(1):15914. doi: 10.1038/s41598-018-33788-y.
28. Liu Y^#, Han TL^#, Luo X, Bai Y, Chen X, Peng W, Xiong X, Baker PN, Tong C*, Qi H*. The metabolic role of LncZBTB39-1:2 in the trophoblast mobility of preeclampsia. Genes Dis. 2018 Apr 24;5(3):235-244. doi: 10.1016/j.gendis.2018.04.005.
29. Yang X^#, Xu P^#, Zhang F^#, Zhang L, Zheng Y, Hu M, Wang L, Han TL, Peng C, Wang L, Wen L, Zeng Y, Gao R, Xia Y, Tong C*, Yang Z*, Qi H*, Baker PN. AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia. Cell Physiol Biochem. 2018. 49(2):578-594. doi: 10.1159/.
30. Li J^#, Tong C^#*, Xu P, Wang L, Han TL, Wen L, Luo X, Tan B, Zhu F, Gui S, Gao R, Qi H*, Baker PN. QSOX1 regulates trophoblastic apoptosis in preeclampsia through hydrogen peroxide production. J Matern Fetal Neonatal Med. 2019. 32(22):3708-3715. doi: 10.1080/**.2018.**.
31. Tong C, Wen L, Xia Y, Leong P, Wang L, Fan X, Han TL, Craig JM, Baker P, Saffery R, Qi H*. Protocol for a longitudinal twin birth cohort study to unravel the complex interplay between early-life environmental and genetic risk factors in health and disease: the Chongqing Longitudinal Twin Study (LoTiS). BMJ Open 2018; Feb 22;8(2): e017889. doi: 10.1136/bmjopen-2017-017889.
32. Delplancke TDJ^#,de Seymour JV^#,Tong C^#,Sulek K,Xia Y,Zhang H,Han TL*,Baker PN. Analysis of sequential hair segments reflects changes in the metabolome across the trimesters of pregnancy. Sci Rep.2018. 8(1):36. doi: 10.1038/s41598-017-18317-7.
33. Wang L, Qi H, Baker PN, Zhen Q, Zeng Q, Shi R, Tong C*, Ge Q*. Altered Circulating Inflammatory Cytokines Are Associated with Anovulatory Polycystic Ovary Syndrome (PCOS) Women Resistant to Clomiphene Citrate Treatment. Med Sci Monitor. 2017. 23:1083-1089.
34. Wang L, Luo X, Li C, Huang Y, Xu P, Lloyd-Davies LH, Delplancke T, Peng C, Gao R, Qi H, Tong C*, Baker P. Triethylenetetramine Synergizes With Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell. Oxid Med Cell Longev. 2017:**.
35. Tong C, Peng C, Wang LL, Zhang L, Yang XT, Xu P, Li JJ, Delplancke T, Zhang H*, Qi HB*. Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury. Nutrients. 2016. 8(3): E138.
36. Tong C, Feng X, Chen J, Qi X, Zhou L, Shi S, Kc K, Stanley JL, Baker PN, Zhang H*. G protein-coupled receptor 30 regulates trophoblast invasion and its deficiency is associated with preeclampsia. J Hypertens. 2016. 34(4):710-8.
37. Leping Zhao, Yong Pan, Kesong Peng, Zhe Wang, Jieli Li, Dan Li, Chao Tong*,Yi Wang*, Guang Liang. Inhibition of 11b-HSD1 by LG13 improves glucose metabolism in type 2 diabetic mice. Journal of Molecular Endocrinology. 2015, 55, 119–131
38. Law KP,* Han TL, Tong C*, Baker PN., Mass Spectrometry-Based Proteomics for Pre-Eclampsia and Preterm Birth. Int J Mol Sci. 2015, 16, 10952-10985.
39. Tong C., Morrison A., Mattison S., Qian S., Bryniarski M., Rankin B., Wang J., Thomas P., Li J*. Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress. FASEB J. 2013 27 11:4332-4342.
40. Tong C., Morrison A., Yan X., Zhao P., Yeung E. D., Wang J., Xie J. and Li J*. Macrophage migration inhibitory factor deficiency augments cardiac dysfunction in Type 1 diabetic murine cardiomyocytes. J Diabetes, 2010, 2:267–274.







研究方向
重大妊娠疾病、心血管疾病、代谢、衰老