丁敏
学术学位博士生导师

教授
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检验医学院





学科信息


个人简介



丁敏，教授，博士生导师，重庆市色谱学会副理事长。1984年毕业于成都科技大学化学系（本科），1988-1991年在重庆医科大学攻读药物分析硕士，获医学硕士学位。1999年8月在香港中文大学参加暑期高级生化学习班。2004年7-12月 在日本岛根大学医学部中心实验室研修。获2003年首批重庆市优秀中青年骨干教师资助,第一批重庆高校创新团队临床检验诊断学创新团队成员。
从1984年-至今在重庆医科大学从事生物分析化学的教学和科研工作，主要从事生物活性物质和药物的分析方法的研究，尤其是对HPLC、MS的分析方法的研究。
主持国家自然科学基金”胆汁酸代谢物轮廓分析用于妊娠肝内胆汁淤积症的诊断和分度”（No:）； 参加自然科学基金“基因修饰的DC细胞抗HBV研究”项目（No：**）；主持“尿硫酸化胆汁酸代谢轮廓分析用于妊娠肝内胆汁淤积症诊断和分度”，高等学校博导基金联合资助课题（201**），主持和参与市级和校级多项课题。


在European Journal of Human Genetics，Analyst，Clinica Chimica Acta、分析化学、中华医学检验杂志等杂志发表论文60余篇，发明专利3项，主、参编6本教材。





论文情况

Wenjing Lyu^#, Xiaoqing Zhang^#, Zhong Zhang, Xiao Chen, Ying Zhou, Hong Chen, Haoran Wang, Min Ding*. A simple and sensitive electrochemical method for the determination of capsaicinoids in chilli peppers. Sensors & Actuators: B. Chemical, 2019, 288: 65-70.
Yue Cui, Biao Xu, Xiaoqing Zhang, Yifan He, Yong Shao, Min Ding^,?_, Diagnostic and therapeutic pro?les of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study.Clinica Chimica Acta 483 (2018) 135–141
Ming Zuoa,, Qianna Zhenb,, Xiaoqing Zhang, Wenbi Zou, Xiangchun Yang, Gang Tian,Zhenghu Shi, Qifu Li, Min Ding^,?. High speci?city of spot urinary free metanephrines in diagnosis and prognosis of pheochromocytomas and paragangliomas by HPLC with electrochemical detection.Clinica Chimica Acta 478 (2018) 82–89
.Gang Tian^#,, Min Ding^#, Biao Xu, Yifan He, Wenjing Lyu, Mingchao Jin, Xiaoqing Zhang*. A novel electrochemical biosensor for ultrasensitive detection of serum total bile acids based on enzymatic reaction combined with the double oxidation circular amplification strategy. Biosensors & Bioelectronics, 2018, 118: 31-35.
Zhang Xiaoqing, Zhu Mingsong, Xu Biao,Yue Cui, Gang Tian, Zhenghu Shi, Min Ding* Indirect electrochemical detection for total bile acids in human serum. Biosensors & Bioelectronics, 2016, 85: 563-567
Mingchao Jin^#, Xiaoqing Zhang^#, QianNa Zhen, YiFan He, Xiao Chen, Wenjing Lyu, Runchuan Han, Min Ding*. An electrochemical sensor for indole in plasma based on MWCNTs-chitosan modified screen-printed carbon electrode. Biosensors & Bioelectronics, 2017, 98: 392
Gang Tian, Xiao-Qing Zhang, Ming-Song Zhu, Zhong Zhang, Zheng-Hu Shi, Min Ding. Quantification of ethanol in plasma by electrochemical detection with an unmodified screen printed carbon electrode. Scientific Reports, | 6:23569 | DOI: 10.1038/srep23569
Li Ma, Xiao-Qing Zhang, Da-Xue Zhou, Yue Cui, Lin-Lin Deng, Ting Yang, Yong Shao,Min Ding.Feasibility of urinary microRNA profiling detection in intrahepatic cholestasis of pregnancy and its potential as a non-invasive biomarker
Scientific Reports, |6:31535 | DOI: 10.1038/srep31535
Jieying Gao, Biao Xub, Xiaoqing Zhang , Yue Cui , Linlin Deng , Zhenghu Shi, Yong Shao, Min Ding*. Association between serum bile acid profiles and gestational diabetes mellitus: A targeted metabolomics study. Clinica Chimica Acta. 2016, 459, 63-72
Xiaoqing Zhang, Mingsong Zhu, Biao Xu, Yue Cui, Gang Tian, Zhenghu Shi, Min Ding*. Indirect electrochemical detection for total bile acids in human serum. Biosensors and Bioelectronics，2016, 85, 563-567
Jieying Gao, Jian Wang, Ming Zuo, Li Ma, Yue Cui, Ting Yang, Min Din g*. A highly sensitive method for simultaneous determination of the quaternary ammonium pesticides chlormequat and mepiquat in pears and potatoes by modified QuEChERS-high performance liquid chromatography-tandem mass spectrometry. RSC Adv, 2015, 5, 5895-903
Li Ma, Jun He, Xiaoqing Zhang, Yue Cui, Jieying Gao, Xiufang Tang and Min Ding*.Determination of total, free, and reduced homocysteine and related aminothiols in uremic patients undergoing hemodialysis by precolumn derivatization HPLC with ?uorescence detection. RSC Adv, 2014,4, 58412–6
Ming Zuo, Jieying Gao, Xiaoqing Zhang, Yue Cui, Zimian Fan, Min Ding*. Capillary electrophoresis with electrochemiluminescence detection for the simultaneous determination of cisatracurium besylate and its degradation products in pharmaceutical preparations. J. Sep. Sci. 2015, 38, 2332–2339
Minglin Ou, Xiaoqing Zhang, Yong Dai, Jieying Gao, Mingsong Zhu, Xiangchun Yang, Yuchao Li, Ting Yang, Min Ding *. Identi?cation of potential microRNA–target pairs associated with osteopetrosis by deep sequencing, iTRAQ proteomics and bioinformatics. European Journal of Human Genetics, 22: 625–632, 2014
Jieying Gao, Ting Yang, Mao Ye, Xiaoqing Zhang, Gang Tian,Qianna Zhen, Min Ding?, High-performance liquid chromatography assay with programmed flow elution for cisatracurium in human plasma: Application to pharmacokinetics in infants and children, Journal of Chromatography B, 955–956 : 58–63, 2014
Xiaoqing Zhang,Wenping Deng,Yanna Ban, Jieying Gao, Min Ding*. A highly sensitive electrically driven electrochemiluminescent assay for quanti?cation of bile acids in human serum. Analyst, 138: 5074-5080, 2013
Jianbo Chen, Wenping Deng, Junwei Wang, Yong Shao, Minglin Ou, Min Ding. Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy. International Journal of Gynecology & Obstetrics, 122:5-8, 2013
唐秀芳, 王箭, 张晓清, 高茹菲, 丁敏*. 高效液相色谱-程序波长紫外检测法同时测定小鼠红细胞中S-腺苷甲硫氨酸和S-腺苷同型半胱氨酸. 分析化学, 41(4): 570-574, 2013
唐秀芳, 甄乾娜, 樊子勉, 冯成亚, 丁敏*. 柱前衍生高效液相色谱荧光检测法测定血浆同型半胱氨酸. 色谱, 30(6): 613-617, 2012
马莉, 张名均, 甄乾娜, 田刚, 丁敏*. HPLC—UV检测法同时测定血浆色氨酸和犬尿氨酸的方法学研究. 中华检验医学杂志, 34(12): 1057-1061, 2011
Qianna Zhen, Biao Xu, Li Ma, Gang Tian, Xiufang Tang, Min Ding*. Simultaneous determination of tryptophan, kynurenine and 5-hydroxytryptamine by HPLC: Application in uremic patients undergoing hemodialysis. Clinical Biochemistry, 44: 226-230, 2011
田刚, 甄乾娜, 班艳娜, 唐秀芳, 丁敏*. 血清胆汁酸代谢轮廓分析在妊娠肝内胆汁淤积症诊断中的应用. 重庆医科大学学报, 36(5): 586-588, 2011
丁敏, 王箭, 张晓清, 邓文平. 酶促电化学发光法测定血清总胆汁酸. 分析化学, 38(12): 1793-1796, 2010
Qianna Zhen, Biao Xu, Li Ma, Gang Tian, Xiufang Tang, Min Ding. Simultaneous determination of tryptophan, kynurenine and 5-hydroxytryptamine by HPLC: Application in uremic patients undergoing hemodialysis. Clinical Biochemistry, 2011 (44) :226–230
丁敏, 王箭, 张晓清, 邓文平. 酶促电化学发光法测定血清总胆汁酸.分析化学，2010，38(12):1793～1796





团队主要成员
丁敏 教授，邵勇 教授，张晓清 副教授，胥飚 副主任技师

指导研究生情况(近五年)
11名硕士研究生，2名博士研究生





研究方向
体内生物活性物质的分析方法研究，检验诊断新方法研究