曾春雨
专业学位博士生导师







国科大(重庆学院)





学科信息


个人简介


成果奖励
1. 2017年“高血压及并发症诊疗新技术研发和临床应用”获重庆市科技进步一等奖,第一完成人。
2. 2015年“GRK4调控受体失稳态在高血压病发生中的作用和转化研究”获重庆市自然科学一等奖，第一完成人。
3. 2009年“高血压病发生过程中的神经体液因子作用研究” 获重庆市科技进步二等奖，第一完成人。
4. 2007年“多巴胺受体功能异常在原发性高血压发病机制中的作用研究” 获重庆市科技进步二等奖第一完成人。



科研项目
1. 2020.01-2024.12.国家自然基金重点项目（No.**）““母婴对话”对心肌增殖基因和表观遗传的双重影响在调控心肌细胞增殖中的作用研究”， 课题组负责人， 经费: 297万元。
2.2019.02-2020.02. 中央引导地方科技发展专项资金;“互联网+”高血压健康管理模式研究与推广，课题组负责人，经费: 30万元。
3.2018.09-2020.12. 国家重大慢性非传染性疾病防控研究重点专项2018年项目“基于高血压肾病和 “器官不良对话”关键发病机制的综合干预研究”，项目编号为2018YFC**，课题组负责人,项目专项经费1595万元。
4.2018.01-2022.12. 国家自然基金重点项目(No. **)“GRK4在孕期不良刺激致子代高血压跨代遗传中的作用和机制研究”，课题组负责人， 经费: 321万元。
5.2017.06-2019.06.重庆市社会事业与民生保障科技创新专项重点项目(cstc2017shms-zdyf0134)，高血压“互联网+社区”医养结合综合管理模式研究与示范，课题组负责人，经费: 50万元。
6.2016.07-2019.06.重庆高校创新团队建设计划--重庆高校“高血压相关疾病”创新团队(CXTDX)，课题组负责人，经费: 60万元。
7.2016.01-2017.12. 重庆市社会事业与民生保障科技创新专项(No. Csct2015shms-ztzx10008)“健康稳态与健康干预关键共性技术研发与集成创新”，课题组负责人，经费: 50万元。
8.2015.01-2018.12. 国家自然科学基金(No. **)“GRK4 A486V变异体在心肌梗死中的作用及机制研究”，课题组负责人，经费: 73万元。
9.2015.01-2019.12. 国家自然基金重点项目(No. **)“胃肠-肾脏尿钠排泄轴在高血压病发生中的作用和机制研究”, 课题组负责人, 经费: 316万元。
10.2013.01-2015.12. ****和创新团队发展计划(Supported by Program for Changjiang Scholars and Innovative Research Team in University；PCSIRT)(IRT1216)，“代谢性心血管病教育部创新团队”， 课题组负责人，经费60万元。
11.2013.01-2017.12. 973项目骨干 (2013CB531104)，“心律失常的发病机理和干预研究”，课题组负责人，经费: 213万元。
12.2012.01-2016.12. 973项目PI (2012CB517801)，“环境代谢因素致高血压机制及其干预措施的研究”，课题组负责人，经费: 512万元。
13.2012.01-2016.12. 国家自然基金重点项目(No. **)“多巴胺受体对a/b₁-、AT₁受体抑制作用在高血压病发生中的作用和机制研究”, 课题组负责人, 经费: 300万元。
14.2011.01-2013.06. 国家科技支撑计划“重庆创新医疗器械研发及推广示范工程-心电检测诊断设备示范评价”( 2011BAI14B03-03),课题组负责人, 经费: 30万元。课题组负责人。
15.2010.01-2013.12. 国家****科学基金(No. **)，课题组负责人, 经费: 200万元。
16.2009.01-2011.12.重庆市****科学基金（CSTC,2009BA5044）(GRK4变异体A142V对血管AT1受体的调节作用与高血压发生的关系研究)，课题组负责人,经费: 60.0万元。
17.2008.03-2009.12. 国家科学技术部973计划前期研究专项“癌症与心血管疾病防治新方法研究” (No. 2008CB517300；首席科学家)，课题组负责人,课题组: 70.0万元。
18.2007.01-2009.12.国家自然基金面上项目(No.**)“G蛋白激酶4变异体A486V在高血压病肾脏多巴胺D3受体功能障碍中的作用研究”，课题负责人,经费: 28万元。
19.2005.01-2007.12.国家自然基金面上项目(No. **)“GRK4变异体A142V对原发性高血压肾脏AT1受体调控的机制”，课题负责人,经费:22万元。



论文情况
在“Circulation、Circ Res、Eur Heart J、Sci Transl Med、Nat Commun、Hypertension、Kidney Int”等杂志发表SCI论文130余篇，4篇文章分别在“Nat Cell Biol、Circulation、Nat Commun、J Hepatol”审稿中。发表的文章最高影响因子23.4，累计影响因子600余分，IF>10.0的10篇；发表文章被“Nat Rev Cardiol、Hypertension、Kidney Int”等杂志述评，被评为“中国心血管领域十大进展、十大影响力事件”、被Nat Rev Cardiol评为年度里程碑影响(important milestone)；多篇文章入选F1000。
1. Fu W, Xu Z, Li L, Shou J, Qu S, Tang L, Shi Y, Yang D, Liao Q, Wu G, Wang WE, Zeng C. Loss of long non-coding RNA ANP promotes cardiomyocyte proliferation and heart regeneration. Circ Heart Fail, 2019, de novo. IF: 5.68
2. Yu J, Yang Y, Xu Z, Lan C, Chen C, Li C, Chen Z, Yu C, Xia X, Liao Q, Jose PA, Zeng C, Wu G. Long Noncoding RNA Ahit Protects Against Cardiac Hypertrophy Through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-Mediated Downregulation of MEF2A (Myocyte Enhancer Factor 2A). Circ:Heart Fail, 2020 Jan;13(1):e006525. doi: 10.1161/CIRCHEARTFAILURE.119.006525. Epub 2020 Jan 20. IF: 6.033
3. Liu G, Wu F, Jiang X, Que Y, Qin Z, Hu P, Lee KSS, Yang J, Zeng C, Hammock BD, Tong X. Inactivation of SERCA2 cysteine 674 increases blood pressure by induction of endoplasmic reticulum stress and soluble epoxide hydrolase. Br J Pharmacol. 2019 Nov 23. doi: 10.1111/bph.14937. [Epub ahead of print]. IF: 6.583
4. Wu L, Gong Z, Wang H, Zhou Z, Zhang M, Liu C, Ren H, Han Y, Zeng C. TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation. Acta Pharmacol Sin. 2020 Jan;41(1):34-46. doi: 10.1038/s41401-019-0293-x. Epub 2019 Sep 12. IF: 4.01
5. Zou X, Wang J, Chen C, Tan X, Huang Y, Jose PA, Yang J, Zeng C. Secreted monocyte miR-27a, via mesenteric arterial Mas receptor-eNOS pathway, causes hypertension. Am J Hypertens,2020 Jan 01;33(1):31-42.IF: 2.53
6. Liao Q, Qu S, Tang LX, Li LP, He DF, Zeng CY, Wang WE. Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis. Acta Pharmacol Sin, 2019 Oct;40(10):1314-1321.IF: 4.01
7. Chen K, Sun D, Qu S, Chen Y, Wang J, Zhou L, Jose PA, Yang Y, Zeng C. Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system. Clin Sci. 2019 May 9;133(9):1097-1113. IF: 5.22
8. Xie S, Fu W, Yu G, Hu X, Lai KS, Peng X, Zhou Y, Zhu X, Christov P, Sawyer L, Ni TT, Sulikowski GA, Yang Z, Lee E, Zeng C, Wang WE, Zhong TP. Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair. J Mol Cell Biol. 2020 Jan 22;;12(1):42-54. pii: mjz023. doi: 10.1093/jmcb/mjz023. [Epub ahead of print]. IF: 5.6
9. Wang S, Tan X, Chen P, Zheng S, Ren H, Cai J, Zhou L, Jose PA, Yang J, Zeng C. Role of thioredoxin 1 in the impaired renal sodium excretion in hD₅R^F173L transgenic mice. J Am Heart Assoc. 2019 Apr 16;8(8):e012192. IF: 4.45
10. Fan Y, Chen Y, Zhang J, Yang F, Hu Y, Zhang L, Zeng C, Xu Q. Protective Role of RNA Helicase DEAD-Box Protein 5 in Smooth Muscle Cell Proliferation and Vascular Remodeling. Circ Res, 2019 May 10;124(10):e84-e100. doi: 10.1161/CIRCRESAHA.119.314062. [Epub ahead of print]. IF: 15.21
11. Yang J, Villar VAM, Rozyyev S, Jose PA, Zeng C. The emerging role of sorting nexins in cardiovascular diseases. Clin Sci. 2019 Mar 15;133(5):723-737. IF: 5.22
12. Gong Z, Han Y, Wu L, Xia T, Ren H, Yang D, Gu D, Wang H, Hu C, He D, Zhou L, Zeng C. Translocator protein 18?kDa ligand alleviates neointimal hyperplasia in the diabetic rat artery injury model via activating PKG. Life Sci, 2019 Mar 15;221:72-82. doi: 10.1016/j.lfs.2019.02.015. Epub 2019 Feb 7. IF: 3.448
13. Yu J, Zeng C, Wang Y. Epigenetics in dilated cardiomyopathy. Curr Opin Cardiol. 2019 May;34(3):260-269. IF:2.05
14. Fu W, Wang WE, Zeng C. Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt inhibitors. Acta Pharmacol Sin 2019 Jan;40(1):9-12.IF: 4.01
15. Sun D, Chen K, Wang J, Zhou L, Zeng C. In-utero cold stress causes elevation of blood pressure via impaired vascular dopamine D1 receptor in offspring. Clin Exp Hypertens. 2020;42(2):99-104.. IF: 1.37
16. Li C, Hu Z, Zhang W, Yu J, Yang Y, Xu Z, Luo H, Liu X, Liu Y, Chen C, Cai Y, Xia X, Zhang X, Wang DZ, Wu G, Zeng C. Regulation of cholesterol homeostasis by a novel long non-coding RNA LASER. Sci Rep. 2019 May 22;9(1):7693.IF: 4.12
17. Gong X, Wu G, Zeng C. Role of circular RNAs in cardiovascular diseases. Exp Biol Med 2019 Feb;244(2):73-82.:**22988. IF: 2.413
18. Yang D, Fu W, Li L, Xia X, Liao Q, Yue R, Chen H, Chen X, An S, Zeng C, Wang WE. Correction: Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction. Clin Sci (Lond). 2019 Jan 11;133(1):149.
19. Wu G, Jose PA,Zeng C. Noncoding RNAs in the Regulatory Network of Hypertension. Hypertension 2018 Nov;72(5):1047-1059. IF: 6.823
20. Chen Z, Chen L, Zeng C, Wang WE. Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction. Stem Cells Int. 2018 Nov 25;2018:**. IF:3.8
21. Wang J,Deng Y,Zou X,Luo H,Jose PA,Fu C,Yang J,Zeng C.Long-term low salt diet increases blood pressure by activation of the renin-angiotensin and sympathetic nervous systems.Clin Exp Hypertens. 2018 Nov 18:1-8. IF:1.44
22. Luo H, Chen C, Guo L, Xu Z, Peng X, Wang X, Wang J, Wang N, Li C, Luo X, Wang H, Jose PA, Fu C, Huang Y, Shi W, Zeng C. Exposure to maternal diabetes causes renal dopamine D₁receptor dysfunction and hypertension in adult rat offspring. Hypertension, 2018 Oct;72(4):962-970. IF: 6.82
23. Wang Z, Chen K, Han Y, Zhu H, Zhou X, Tan T, Yue R, Zeng J, Zhang J, Fu J, Liu Y, Wang X, Li Y, Yao Y, Park KH, Yi J, Zhou J, Ma J, Zeng C. Irisin protects heart against-reperfusion injury through a SOD2-dependent mitochondria mechanism. J Cardiovasc Phamarcol 2018 Dec;72(6):259-269. IF: 2.23
24. Yang X, Yue R, Zhang J, Zhang X, Liu Y, Chen C, Wang X, Luo H, Wang WE, Wang H, Zeng C. Gastrin protects against myocardial ischemia/reperfusion-injury via activation of RISK and SAFE pathways. J Am Heart Assoc 2018 Jul 12;7(14). pii: e005171. IF: 5.11
25. Ye Z, Lu X, Deng Y, Wang X, Zheng S, Ren H, Zhang M, Chen T, Jose PA, Yang J, Zeng C. In utero exposure to fine particulate matter causes hypertension due to impaired renal dopamine D₁ receptor in offsprings. Cell Physiol Biochem 2018, Mar 21;46(1):148-159. IF: 5.104
26. Lu X, Ye Z, Zheng S, Ren H, Zhang J, Wang X, Chen K, Zeng C. Long-term exposure of PM2.5 causes hypertension by impaired renal D₁ receptor mediated sodium excretion via up-regulation of GRK4 expression in SD rats. J Am Heart Assoc 2018 Jan 7;7(1). pii: e007185. IF: 5.11
27. Yin Z, Zeng C, Zhang X, Yang C, Wang H, Song W, Wang X, Fu C, Shi W, Fang Y. The characteristics of coronary stenosis in 11,267 patients from Southwest China: a retrospective study. J Thromb Thrombolysis. 2018 Jan;45(1):142-150. IF: 2.1
28. Lan C, Chen X, Wang W, Wang WE, Liu Y, Cai Y, Ren H, Zheng S, Zhou L, Zeng C. Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function. BMC Cardiovasc Disord, 2018 Mar 1;18(1):43. doi: 10.1186/s12872-018-0768-6. IF: 1.83
29. Yang Y, Chen C, Fu C, Zhang Y, Zeng C. Angiotensin II type 2 receptor inhibits expression and function of insulin receptor in rat renal proximal tubule cells. J Am Soc Hypertens 2018 Feb;12(2):135-145.IF: 2.66.
30. Yang D, Fu W, Li L, Xia X, Liao Q, Yue R, Chen H, Chen X, An S, Zeng C, Wang WE. Therapeutic effect of a novel WNT pathway inhibitor on cardiac regeneration after myocardial infarction. Clin Sci 2017 Dec 8;131(24):2919-2932. IF: 4.9
31. Chen K, Xu Z, Liu Y, Wang Z, Li Y, Xu X, Chen C, Xia T, Liao Q, Yao Y, Zeng CS, He D, Tan T, Zhou X, Zhou J, Zhu H, Ma J, Zeng C. Irisin protects mitochondria function during pulmonary ischemia reperfusion injury. Sci Transl Med, 2017 Nov 29;9(418). pii: eaao6298. IF: 16.796
32. Qu S, Zeng C, Wang W. Noncoding RNA and Cardiomyocyte Proliferation. Stem Cell Int 2017;2017:**. IF: 3.54
33. Chen Z, Zeng C, Wang WE. Progress of Stem Cell Transplantation for Treating Myocardial Infarction. Curr Stem Cell Res Ther. 2017;12(8):624-636. IF: 2.645.
34. Wang WE, Li L, Yue R, Xia X, Yang D, Chen H, Peng Y, Zhou L, Duan DD, Zhou B, Chen X, Houser SR, Zeng C. Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury. Circulation 2017 Aug 29;136(9):834-848. IF: 19.3
35. Tang L, Yang J, Zeng C. Potential benefit of (-)-epigallocatechin-3-gallate for macrovascular complications in diabetes, Braz J Med Biol Res 2017 Aug 17;50(10):e6511. IF: 1.146
36. Yang J, Jose PA, Zeng C. Gastrointestinal-renal axis: role in the regulation of blood pressure. J Am Heart Assoc. 2017 Mar 6;6(3). pii: e005536. IF: 5.11
37. Wang N, Chen C, Tang D, Liao Q, Luo H, Wang X, Zhou F, Yang X, Yang J, Zeng C, Wang WE. Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis. Biochim Biophys Acta - Mol Bas Dis. 2017 Aug;1863(8):2085-2092. IF: 5.15
38. Fan Y, Zhang J, Chen CY, Xiao YB, Asico LD, Jose PA, Xu JC, Qian GS, Zeng CY. Macrophage migration inhibitory factor triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor axis. Cardiovasc Res. 2017 Apr 1;113(5):519-530 . IF: 5.9
39. Yue R, Fu W, Liao X, Lan C, Liao Q, Li L, Yang D, Xia X, Chen X, Zeng C, Wang WE. Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction. Stem Cell Res Ther 2017 Jan 28;8(1):17. IF: 4.5
40. Tang L, Zheng S, Ren H, He D, Zeng C, Wang WE. Activation of Angiotensin II type 1 receptor increases D₄ dopamine receptor expression in rat renal proximal tubule cells. Hypertens Res, 2017; 40(7):652-657. IF: 3.2
41. Xia X, Zhou Y, Luo H, Zeng C. Inhibitory effect of D₃ dopamine receptors on neuropeptide Y-induced migration in vascular smooth muscle cells. Mol Med Rep 2017 Oct;16(4):5606-5610. IF: 1.559
42. Han Y, Lia X, Gao Z, Yang S, Chen C, Liu Y, Fu J, Wang WE, Wu G, Chen X, Jose PA, Zhang Y, Zeng C. Cardiac troponin I exacerbates myocardial ischemia/reperfusion injury by inducing the adhesion of monocytes to vascular endothelial cells via a TLR4/NF-κB-dependent pathway. Clin Sci (Lond). 2016;130(24):2279-2293. IF: 5.63
43. Fu J, Han Y, Wang J, Liu Y, Zheng S, Zhou L, Jose PA, Zeng C. Irisin lowers blood pressure by improvement of endothelial dysfunction via AMPK-Akt-eNOS-NO pathway in the spontaneously hypertensive rat. J Am Heart Assoc, 2016 Oct 26;5(11). pii: e003433. IF: 5.11.
44. Cai J, Wu G, Jose PA, Zeng C. Functional transferred DNA within extracellular vesicles. Exp Cell Res 2016;349(1):179-183. IF: 3.378
45. Huang H, Li X, Zheng S, Chen Y, Chen C, Wang J, Tong H, Zhou L, Yang J, Zeng C. Downregulation of renal G protein-coupled receptor kinase type 4 expression via ultrasound-targeted microbubble destruction lowers blood pressure in spontaneously hypertensive rats. J Am Heart Assoc 2016 Oct 6;5(10). pii: e004028. IF: 5.11
46. Yang J, Villar VAM, Armando I, Jose PA, Zeng C. G protein-coupled receptor kinases: crucial regulators of blood pressure. J Am Heart Assoc 2016 Jul 7;5(7). pii: e003519. IF: 5.11
47. Li C, Gao M, Zhang W, Chen C, Zhou F, Hu Z, Zeng C, Hu Z*, Zeng C*. Zonulin regulates intestinal permeability and facilitates permeation of enteric Bacteria to blood in coronary artery disease. Sci Rep. 2016 Jun 29;6:29142. IF: 5.57
48. Yao Y, Wang W, Li M, Ren H, Chen C, Wang J, Wang WE, Yang J, Zeng C. Curcumin exerts its anti-hypertensive effect by down-regulating the AT₁ receptor in vascular smooth muscle cells. Sci Rep 2016 May 5;6:25579. IF: 5.57
49. Zhang Y, Ren H, Lu X, He D, Han Y, Wang H, Zeng C*, Shi W*. Inhibitory effect of D₄ receptor on insulin receptor expression and function in renal proximal tubule cells. J Am Heart Assoc 2016 Apr 22;5(4). pii: e002448. IF: 5.11
50. Xia T, Guan W, Fu J, Zou X, Han Y, Chen C, Zhou L, Zeng C*, Wang WE*. Tirofiban induces vasorelaxation of the coronary artery via an endothelium-dependent NO-cGMP signaling by activating the PI3K/Akt/eNOS pathway. Biochem Biophys Res Commun 2016 Jun 3;474(3):599-605. IF: 2.297.
51. Yao Y, Zhang B, Zhu H, Li H, Han Y, Chen K, Wang Z, Zeng J, Liu Y, Wang X, Li Y, He D, Lin P, Zhou X, Park KH, Bian Z, Chen Z, Gong N, Tan T, Zhou J, Zhang M, Ma J, Zeng C. MG53 permeates through blood-brain barrier to protect ischemic brain injury. Oncotarget. 2016 Apr 19;7(16):22474-85. IF: 6.359
52. Li C, Luo X, Zhang W, Zhou L, Wang H, Zeng C. YaAn earthquake increases blood pressure among hospitalized patients. Clin Exp Hypertens 2016;38(6):495-9.IF: 1.234
53. Zhang Y, Zeng C. Role of DNA methylation in cardiovascular diseases. Clin Exp Hypertens 2016;38(3):261-7. IF: 1.234
54. Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C. Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways. PLoS One 2016 Feb 11;11(2):e**. IF: 3.23
55. Cai Y, Yang Y, Chen X, He D, Zhang X, Wen X, Hu J, Fu C, Qiu D, Jose PA, Zeng C, Zhou L. Circulating "LncPPARδ" from monocytes as a novel biomarker for coronary artery diseases. Medicine (Baltimore). 2016 Feb;95(6):e2360. IF: 5.723
56. Zhang Y, Chen C, He D, Shi W, Fu C, Wang X, Zeng C. Transcriptional gene silencing of dopamine D₃ receptor caused by let-7d mimics in immortalized renal proximal tubule cells of rats. Gene 2016 Apr 15;580(2):89-95. IF: 2.138
57. Cai Y, Yang Y, Chen X, Wu G, Zhang X, Liu Y, Yu J, Wang X, Fu J, Li C, Jose PA, Zeng C, Zhou L. Circulating "lncRNA OTTHUMT" from monocytes as a novel biomarker for coronary artery diseases. Cardiovasc Res 2016;112(3):714-724. IF: 5.81
58. Li L, Chen X, Wang WE, Zeng C. How to improve the survival of transplanted mesenchymal stem cell in ischemic heart? Stem Cell Int 2016;2016:**.IF: 2.8
59. Yao Y, Yang D, Han Y, Wang W, Wang N, Yang J, Zeng C. Dopamine D₁-Like Receptors Suppress the Proliferation of Macrophages Induced by Ox-LDL. Cell Physiol Biochem. 2016;38(1):415-426.IF: 3.55
60. Wang Z, Zeng C, Villar VAM, Chen SY, Konkalmatt P, Wang X, Asico LD, Jones JE,Yang Y,Sanada H, Felder RA, Eisner GM, Weir MR, Armando I, Jose PA. HumanGRK4 A142Vvariant promotes AT₁R-mediated hypertension via renal HDAC1 inhibition. Hypertension 2016 Feb;67(2):325-34.
61. Yang Y, Cai Y, Wu G, Chen X, Liu Y, Wang X, Yu J, Li C, Chen X, Jose PA, Zhou L, Zeng C. Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease. Clin Sci (Lond). 2015 Oct 1;129(8):675-685. IF: 5.63
62. Yuan D, Yu C, Zeng C. Association of I-FABP gene polymorphism and the risk of coronary heart disease. Int J Clin Exp Med. 2015 Sep 15;8(9):16389-16393. IF: 1.277
63. Zhou Y, Shi W, Luo H, Yue R, Wang Z, Wang W, Liu L, Wang WE, Wang H, Zeng C. Inhibitory effect of D₁-like dopamine receptors on neuropeptide Y-induced proliferation in vascular smooth muscle cells. Hypertens Res. 2015 Dec;38(12):807-12. IF: 2.936
64. Li C, Lin L, Zhang W, Zhou L, Wang H, Luo X, Luo H, Cai Y, Zeng C. Efficiency and safety of proprotein convertase subtilisin/kexin 9 monoclonal antibody on hypercholesterolemia: a meta-analysis of 20 randomized controlled trials. J Am Heart Assoc. 2015 Jun 15;4(6):e001937. IF: 5.11
65. Luo H, Wang X, Wang J, Chen C, Wang N, Xu Z, Chen S, Zeng C. Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats. Cardiovasc Diabetol 2015 Jun 10;14:76. IF: 3.7
66. Wang X, Wang J, Luo H, Chen C, Pei F, Cai Y, Yang X, Wang N, Fu J, Xu Z, Zhou L, Zeng C. Prenatal lipopolysaccharide exposure causes mesenteric vascular dysfunction through NO-cGMP pathway in offspring. Free Radic Biol Med. 2015 Sep;86:322-30. IF:5.71
67. Guan W, Wang Z, Han Y, Ren H, Wang WE, Zhou L, Zeng C. Protective effects of tirofiban on ischemia/reperfusion-induced renal injury in rats. Eur J Pharmacol. 2015 May 14;761:144-152. IF: 2.68
68. Wang Z, Han Y, Guan W, Ren H, Tang X, Zhang H, Liu Y, Fu J, He D, Asico LD, Jose PA, Zhou L, Chen L, Zeng C. Stimulation of dopamine D₃ receptor attenuates renal ischemia/reperfusion injury via increased linkage with Ga12. Transplantation 2015 Nov;99(11):2274-84. IF: 3.535
69. Yang J, Villar VAM, Jones J, Jose PA, Zeng C. G protein coupled receptor kinase 4: role in hypertension. Hypertension 2015;65(6):1148-55 IF: 7.63
70. Yu C, Chen J, Han Y, Wang WE, Wang X, Wang H, Zeng C. Activation of the D₄dopamine receptor attenuates proliferation and migration of vascular smooth muscle cells through downregulation of AT_1areceptor expression. Hypertens Res 2015 Sep;38(9):588-96. IF: 2.936
71. Yang S, Han Y, Zheng S, Kou X, Asico LD, Huang H, Gao Z, Jose PA, Zeng C. Enhanced natriuresis and diuresis in Wistar rats caused by the costimulation of renal dopamine D₃ and angiotensin II type 2 receptors. Am J Hypertens 2015 Oct;28(10):1267-76. IF: 3.4
72. Yang S, Yang Y, Yu P, Yang J, Villar VAM, Sibley DR, Jose PA, Zeng C. Dopamine D₁ and D₅ receptors differentially regulate oxidative stress through paraoxonase 2 in kidney cells. Free Radic Res, 2015;49(4):397-410. IF: 2.99
73. Cai J, Guan W, Tan X, Chen C, Li L, Wang N, Zou X, Zhou F, Wang J, Pei F, Chen X, Luo H, Wang X, He D, Zhou L, Jose PA, Zeng C. SRY gene transferred by extracellular vesicles accelerates atherosclerosis by promotion of leukocyte adherence to endothelial cells. Clin Sci, 2015;129(3):259-269. IF: 5.63
74. Luo H, Wang X, Chen C, Wang J, Zou X, Li C, Xu Z, Yang X, Shi W, Zeng C. Oxidative stress causes the imbalance of renal RAS components and hypertension in obese Zucker rats. J Am Heart Assoc. 2015 Feb 16;4(2). pii: e001559. IF: 5.11
75. Yue R, Xia X, Jiang J, Yang D, Han Y, Cai J, Li L, Wang WE, Zeng C. Mitochondrial DNA oxidative damage contributes to cardiac myocytes ischemia/reperfusion-injury of rats: the cardioprotective roles of lycopene. J Cell Physiol 2015 Sep;230(9):2128-41. IF: 3.87
76. Pei F, Wang X, Yue R, Chen C, Huang J, Huang J, Li X, Zeng C. Differentialexpression and DNA methylation of angiotensin type 1A receptorsin vascular tissues during genetic hypertension development. Mol Cell Biochem 2015 Apr;402(1-2):1-8. IF: 2.38
77. Chen K, Deng K, Wang X, Wang Z, Zheng S, Ren H, He D, Han Y, Asico LD, Jose PA, Zeng C. Activation of D₄ dopamine receptor decreases AT₁ angiotensin II receptor expression in rat renal proximal tubule cells. Hypertension 2015;65(1):153-160. IF: 7.63
78. Li Y, Wang N, Chen C, He D, Yang J, Zeng C. Inhibitory effect of D₃ dopamine receptor on migration of vascular smooth muscle cells induced by synergistic effect of angiotensin II and aldosterone. Clin Exp Hypertens. 2015;37(4):288-93.IF: 1.456
79. Wu G, Cai J, Han Y, Chen J, Huang ZP, Chen C, Cai Y, Huang H, Yang Y, Liu Y, Xu Z, He D, Zhang X, Hu X, Pinello L, Zhong D, He F, Yuan GC, Wang DZ, Zeng C. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis and atherosclerosis by enhancing p53 activity. Circulation 2014;130(17):1452-1465. IF: 14.95
80. Wang X, Luo H, Chen C, Chen K, Wang J, Cai Y, Zheng S, Yang X, Zhou L, Jose PA, Zeng C. Prenatal lipopolysaccharide exposure results in dysfunction of renal dopamine D₁ receptor in offspring rats. Free Radic Biol Med. 2014 Nov;76:242-50. doi: 10.1016/j.freeradbiomed.2014.08.010. Epub 2014 Sep 16. IF: 5.271
81. Cai J, Wu G, Tan X, Han Y, Chen C, Li C, Wang N, Zou X, Chen X, Zhou F, He D, Zhou L, Jose PA, Zeng C. Transferred BCR/ABL DNA by K562 extracellular vesicles causes chronic myeloid leukemia in immuno-deficient mice. PLoS One. 2014 Aug 18, 9(8):e105200. IF:3.234
82. Yang J, Mao QX, Xu HX, Ma X, Zeng CY. Tea consumption and risk of type 2 diabetes mellitus: a systematic review and meta-analysis update. BMJ Open. 2014;4(7):e005632. IF: 1.583
83. Yu C, Wang Z, Han Y, Liu Y, Wang WE, Chen C, Wang H, Jose PA, Zeng C. Dopamine D₄ receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression. Cardiovasc Diabetol 2014 Jun 2;13:97. IF:4.015
84. Jia Y, Chen K, Lin P, Lieber G, Nishi M, Yan R, Wang Z, Yao Y, Li Y, Whitson BA, Duann P, Li H, Zhou X, Zhu H, Takeshima H, Hunter JC, McLeod RL, Weisleder N, Zeng C, Ma J. Treatment of acute lung injury by targeting MG53-mediated cell membrane repair. Nat Commun. 2014 Jul 18;5:4387. doi: 10.1038/ncomms5387. IF: 10.74
85. Fu J, Han Y, Wang H, Wang Z, Liu Y, Chen X, Cai Y, Guan W, Yang D, Asico LD, Zhou L, Jose PA, Zeng C. Impaired dopamine D₁ receptor-mediated vasorelaxation of mesenteric arteries in obese Zucker rats. Cardiovasc Diabetol. 2014 Feb 22;13(1):50. IF: 4.209
86. Wang S, Lu X, Yang J, Wang H, Chen C, Han Y, Ren H, Zheng S, He D, Zhou L, Asico LD, Wang WE, Jose PA, Zeng C. Regulation of D₅ dopamine receptor on renalase expression and function in rat renal proximal tubule cells. Am J Physiol Renal Physiol. 2014;306(6):F588-96. IF: 3.682
87. Wang WE, Wang H, Zeng C. A Transition of P2Y12 Antagonists for acute coronary syndrome: benefits, risks and cost. J Thromb Thrombolysis. 2014;37(2):102-6.IF: 1.476
88. Chen K, Fu C, Chen C, Liu L, Ren H, Han Y, Yang J, He D, Zhou L, Yang Z, Zhang L, Jose PA, Zeng C. Role of GRK4 in the regulation of arterial AT₁ receptor in hypertension. Hypertension. 2014;63(2):289-96. IF: 6.873
89. Kou X, Han Y, Yang D, Liu Y, Fu C, Zheng S, He D, Zhou L, Zeng C. Dopamine D₁-like receptors suppress proliferation of vascular smooth muscle cell induced by insulin growth factor-1. Clin Exp Hypertens 2014;6(3):140-147. IF: 1.07
90. Chen J, Wang HY, Zeng CY. Transcriptome network analysis of potential candidate genes for heart failure. Genet Mol Res. 2013;12(4):4687-4697. IF: 0.994
91. Li C, Zhang W, Zhou F, Chen C, Zhou L, Li Y, Liu L, Pei F, Luo H, Hu Z, Cai J, Zeng C. Cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia: a systematic review and meta-analysis. PLoS One. 2013;8(10):e77049.
92. Wang Z, Liu Y, Han Y, Guan W, Kou X, Fu J, Yang D, Ren H, He D, Zhou L, Zeng C. Protective effects of aliskiren on ischemia-reperfusion-induced renal injury in rats. Eur J Pharmacol. 2013;718(1-3):160-6. IF: 2.516
93. Fang Y, Wen C, Yang L, Zhang X, Chu W, Zeng C. Radiofrequency ablation can reverse the structural remodeling caused by frequent premature ventricular contractions originating from the right ventricular outflow tract even in a "normal heart". Clinics (Sao Paulo). 2013;68(10):1312-7. IF: 2.058
94. Liu Y, Chen K, Kou X, Zhou L, Zeng C. Aliskiren and amlodipine in the management of essential hypertension: meta-analysis of randomized controlled trial. Plos One, 2013 Jul 29;8(7):e70111. IF: 4.1
95. Chen Y, Asico LD, Zheng S, Villar VAM, He D, Zhou L, Zeng C, Jose PA. Gastrin and D₁ dopamine receptor interact to induce natriuresis and diuresis. Hypertension 2013;62(5):927-33. IF: 6.873
96. Wang W, Yang D, Li L,Wang W, Peng Y,Chen P, Chen C, Chen P, Xia X, Wang H, Jiang J, Liao Q, Li Y, Xie G, Huang H, Guo Y, Ye L, Duan D, Chen X, Houser SR, Zeng C. Prolyl Hydroxylase Domain Protein 2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium. Circ Res, 2013;113(3):288-300. IF: 11.9
97. Wang WE, Chen X, Houser SR, Zeng C. The potentials of cardiac stem/progenitor cells and induced pluropotent stem cells for cardiac repair in ischemic heart disease. Clin Sci. 2013; 215(7):319-327. IF:4.317 (Highlight paper)
98. Cai J, Han Y, Ren H, Chen C, Li L, He D, Zhou L, Eisner GM, Jose PA, Zeng C. Microvesicle-mediated transfer of DNA is a novel mechanism of genetic exchange between cells. J Mol Cell Biol. 2013 Aug;5(4):227-38. IF: 7.667
99. Yang D, Wang W, Li L, Peng Y, Chen P, Huang H, Guo Y, Xia X, Wang Y, Wang H, Wang WE, Zeng C. The relative role of paracrine effect in the therapeutic function of ADSC transplantation after myocardial infarction. Plos One, 2013;8(3):e59020. doi: 10.1371/journal.pone.**. IF: 4.1
100.Yang J, Han Y, Chen C, Sun H, He D, Guo J, Jiang B, Zhou L, Zeng C. (–)-Epigallocatechin Gallate Attenuates high glucose-induced endothelial cell inflammatory response by suppression of PKC and NF-κB signaling pathways in human umbilical vein endothelial cells. Life Sci. 2013;92(10):589-97. IF: 2.52
101.Wang Y, Han Y, Yang J, Wang Z, Liu L, Wang W, Zhou L, Wang D, Tan X, Fu C, Jose PA, Zeng C. Relaxant effect of all-trans retinoic acid via NO-sGC-cGMP pathway and calcium-activated potassium channels in rat mesenteric artery. Am J Physiol Heart Circ Physiol. 2013;304(1):H51-7. IF: 3.708
102.Zhangxue H, Min G, Jinning Z, Yuan S, Li W, Huapei S, Ru L, Zeng C. Glycochenodeoxycholate induces rat alveolar epithelial type II cell death and inhibits surfactant secretion in vitro. Free Radic Biol Med. 2012;53(1):122-8. IF: 5.423
103.Wang H, Luo X, Wang W, Wang X, Yang C, Zeng C. Successful transcatheter patent ductus arteriosus occluder embolization of a congenital left coronary artery aneurysm and fistulas draining into the right atrium. Ann Thorac Cardiovasc Surg. 2012;18(6):540-3. IF:0.695
104.Fang Y, Shu X, Yang C, Wang X, Wang H, Fu C, Shi W, Zhang Y, Chen Q, Yang L, Zeng C. Stenotic coexistence among coronary, renal and extracrainal arteries in Chinese patients. J Thromb Thrombolysis. 2012; 34(4):533-40. IF: 1.476
105.Li C, Pei F, Zhu X, Duan D, Zeng C. Circulating microRNAs as novel and sensitive biomarkers of acute myocardial infarction. Clin Biochem 2012;45(10-11):727-32. IF: 2.076
106.Yang J, Chen C, Ren H, Han Y, He D, Chen X, Guo J, Yu C, Jiang B, Zhou L, Hoper U, Jose PA, Zeng C. Angiotensin II AT₂ receptor decreases AT₁ receptor expression and function via NO/cGMP/SP1 in renal proximal tubule cells from Wistar-Kyoto rats. J Hypertens 2012;30(6):1176-84. IF:4.021
107.Huang H, Ren H, Chen C, Yang J, Han Y, He D, Asico LD, Jose PA, Zeng C. D₃ dopamine receptor regulation of D₅ receptor expression and function in renal proximal tubule cells. Hypertens Res. 2012;35(6):639-47. IF:2.576
108.Yang J, Han Y, Sun H, Chen C, He D, Guo J, Yu C, Jiang B, Zhou L, Zeng C. (–)-epigallocatechin gallate suppresses high glucose-induced proliferation of vascular smooth muscle cells by inhibition of PKC and ERK1/2 signalings. J Agric Food Chem. 2011;59(21):11483-90. (impact factor 2.816)
109.Zhang Y, Jose PA, Zeng C. Regulation of endothelin on sodium transport in proximal tubule. Contrib Nephrol. 2011;172:63-75. (Review, corresponding author) IF：1.487
110.Zhang Y, Fu C, Asico LD, Ren H, He D, Wang Z, Yang J, Jose PA, Zeng C. Role of Galpha₁₂- and Galpha₁₃-protein subunit linkage of D₃ dopamine receptors in the natriuretic effect of D₃ dopamine receptor in kidney. Hypertens Res. 2011;34(9):1011-6. IF: 3.146
111.Zhang Y, Wang Y, Wang X, Zhang Y, Eisner GM, Asico LD, Jose PA, Zeng C. Insulin promotes vascular smooth muscle cell proliferation via microRNA-208 mediated down-regulation of p21. J Hypertens. 2011;29(8):1560-1568. IF：5.132
112.Zeng J, Jia M, Ran H, Tang H, Zhang Y, Zhang J, Wang X, Wang H, Yang C, Zeng C. Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosing-a multicenter, open-label randomized study. Hypertens Res. 2011;34(6):767-72. IF：3.146
113.Huang H, Han Y, Wang X, Chen C, Yu C, He D, Wang H, Zhou L, Asico LD, Jose PA, Zeng C. Inhibitory effect of the D₃ dopamine receptor on insulin receptor expression and function in vascular smooth muscle cells. Am J Hypertens. 2011;24(6):654-60. IF：3.122
114.Zhang Y, Fu C, Ren H, He D, Wang X, Asico LD, Jose PA, Zeng C. Impaired stimulatory effect of ETB receptor on D₃ receptor in immortalized renal proximal tubule cells of spontaneously hypertensive rats. Kidney Blood Pressure Res. 2011;34:75-82. IF：1.464
115.Zeng C, Jose PA. Dopamine receptor: important antihypertensive counterbalance against hypertensive factors. Hypertension. 2011;57(1):11-7. IF：6.873
116.Fang YQ, Zhang Y, Zeng C. Feasibility and application of single 5F multipurpose catheter in coronary and peripheral angiography via a transradial approach. Int J Cardiol. 2011;151(2):182-186. IF：7.078
117.Zeng C. Clopidogrel application: beyond coronary artery dsease. Clin Sci 2010;118:459-461. IF：4.317
118.Liu Y, Yang J, Ren H, He D, Pascua A, Armando MI, Yang C, Zhou L, Felder RA, Jose PA, Zeng C. Inhibitory effect of ETB receptor on Na⁺-K⁺ ATPase ATPase activity by extracellular Ca²⁺ entry and Ca²⁺ release from the endoplasmic reticulum in renal proximal tubule cells. Hypertens Res. 2009;32(10):846-52.IF：3.146
119.Yu C, Yang Z, Ren H, Zhang Y, Han Y, He D, Lu Q, Wang X, Wang X, Yang C, Asico LD, Hopfer U, Eisner GM, Jose PA, Zeng C. D₃ dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs. Am J Hypertens. 2009;22(8):877-83. IF：3.122
120.Yang J, Cui Z, He D, Ren H, Han Y, Yu C, Fu C, Wang Z, Yang C, Wang X, Zhou L, Asico LD, Villar VA, Hopfer U, Mi M, Zeng C, Jose PA. Insulin increases D₅ dopamine receptor expression and function in renal proximal tubule cells from Wistar-Kyoto rats. Am J Hypertens. 2009;22(7):770-6.IF：3.122
121.Zeng C, Han Y, Huang H, Yu C, Ren H, Shi W, He D, Huang L, Yang C, Wang X, Zhou L, Jose PA. D₁-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression. J Hypertens. 2009;27(5):1033-41. IF：5.132
122.Zeng C, Villar VA, Yu P, Zhou L, Jose PA. Reactive oxygen species and dopamine receptor function in essential hypertension. Clin Exp Hypertens. 2009;31(2):156-78. IF：1.079
123.Zeng C, Asico LD, Yu C, Villar VA, Shi W, Luo Y, Wang Z, He D, Liu Y, Huang L, Yang C, Wang X, Hopfer U, Eisner GM, Jose PA. Renal D₃ dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions. Kidney Int. 2008;74(6):750-9.IF：6.418
124.Li Z, Yu C, Han Y, Ren H, Shi W, Fu C, He D, Huang L, Yang C, Wang X, Zhou L, Asico LD, Zeng C, Jose PA. Inhibitory effect of D₁-like and D₃ dopamine receptors on norepinephrine-induced proliferation in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2008;294(6):H2761-8. IF：3.643
125. Zeng C, Villar VA, Eisner GM, Williams SM, Felder RA, Jose PA. G protein-coupled receptor kinase 4: role in blood pressure regulation. Hypertension. 2008;51(6):1449-55. IF：7.368
126.Zeng C, Armando I, Luo Y, Eisner GM, Felder RA, Jose PA. Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice. Am J Physiol Heart Circ Physiol. 2008;294(2):H551-69.IF：3.643
127.Zeng C, Zhang M, Asico LD, Eisner GM, Jose PA. The dopaminergic system in hypertension. Clin Sci 2007;112(12):583-597. IF：4.187
128.Zeng C, Yang Z, Asico LD, Jose PA. Regulation of blood pressure by D₅ dopamine receptors. Cardiovasc Hematol Agents Med Chem 2007; 5(3):241-248. IF：4.904
129.Zeng C, Liu Y, Wang Z, He D, Huang L, Yu P, Zheng S, Jones JE, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. Activation of D₃ dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Circ Res. 2006;99(5):494-500. IF：11.9
130.Zeng C, Wang Z, Li H, Yu P, Zheng S, Wu L, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. D₃ dopamine receptor directly interacts with D₁ dopamine receptor in immortalized renal proximal tubule cells. Hypertension. 2006;47(3):573-9. IF：7.368
131.Zeng C, Eisner GM, Felder RA, Jose PA. D₃ dopamine receptor and essential hypertension. Curr Hypertens Rev. 2006;2(3):247-253.
132.Zeng C, Felder RA, Jose PA. A new approach for treatment of hypertension: modifying D₁ dopamine receptor function. Cardiovasc Hematol Agents Med Chem 2006;4(4):369-377. IF：4.904
133.Zeng C, Wang Z, Hopfer U, Asico LD, Eisner GM, Felder RA, Jose PA. Rat strain effects of AT₁ receptor activation on D₁ dopamine receptors in immortalized renal proximal tubule cells. Hypertension. 2005;46(4): 799-805. IF：7.368
134.Zeng C, Hopfer U, Eisner GM, Felder RA, Jose PA. Altered AT₁ receptor regulation of ETB receptors in renal proximal tubule cells of spontaneously hypertensive rats. Hypertension. 2005;46(4):926-931.IF：7.368
135.Zeng C, Wang Z, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. Aberrant ETB receptor regulation of AT₁ receptors in renal proximal tubule cells of spontaneously hypertensive rats. Kidney Int 2005;68(2):623-631. IF：4.927
136.Zeng C, Yang Z, Wang Z, Jones JE, Wang X, Altea J, Mangrum AJ, Hoper U, Sibley DR, Eisner GM, Felder RA, Jose PA. Interaction of AT₁ and D₅ dopamine receptors in renal proximal tubule cells. Hypertension. 2005;45(4):804-810.IF：7.368
137.Zeng C, Eisner GM, Felder RA, Jose PA. Dopamine receptor and hypertension. Curr Med Chem Cardiovasc Hematol Agents. 2005;3(1):69-77.IF：4.904
138.Zeng C, Sanada H, Watanabe H, Eisner GM, Felder RA, Jose PA. Functional genomics of the dopaminergic system in hypertension. Physiol Genomics. 2004;19(3):233-46. IF：4.636
139.Zeng C, Wang D, Asico LD, Welch WJ, Wilcox CS, Hopfer U, Eisner GM, Felder RA, Jose PA. Aberrant D₁ and D₃ dopamine receptor transregulation in hypertension. Hypertension 2004;43(3):654-60. IF：7.368
140.Zeng C, Wang D, Yang Z, Wang Z, Asico LD, Wilcox CS, Eisner GM, Welch WJ, Felder RA, Jose PA. D₁ dopamine receptor augmentation of D₃ receptor action in rat aortic or mesenteric vascular smooth muscles. Hypertension 2004;43(3):673-679.IF：7.368
141.Zeng C, Luo Y, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. Perturbation of D₁ dopamine and AT₁ receptor interaction in spontaneously hypertensive rats. Hypertension 2003;42(4):787-792.IF：7.368
142.Zeng C, Asico LD, Wang X, Hopfer U, Eisner GM, Felder RA, Jose PA. Angiotensin II regulation of AT₁ and D₃ dopamine receptors in renal proximal tubule cells of SHR. Hypertension 2003;41(3 pt 2):724-729.IF：7.368
143.Zeng C, Wang X, Liu G, Yang C. Effects of ACE inhibitor and b-adrenergic blocker on plasma NPY and NPY receptors in aortic vascular smooth muscle cells from SHR and WKY rats. Neuropeptides 2002;36(5):353-361. IF2.438
144.Zeng C, Zhou Y, Liu G, Sun W. The signal transduction pathway causing the synergistic hypertrophic effects of neuropeptide Y and norepinephrine on primary cardiomyocyte. Neuropeptides 2001;35(5-6):211-218.IF2.438
145.Zeng C, Liu G, Yang C, Sun W, Wang Y, He D. Evaluation of a single stage nitroglycerin tilt table test for diagnosis of neurally mediated syncope. Pacing Clin Electrophysiol. 2001;24(10):1494-9. IF：1.59
146.Zeng C, Zhu Z, Hu W, Liu G, Zhu S, Zhou Y, Shi W. Value of sublingual isosorbide dinitrate before isoproterenol tilt table test for diagnosis of neurally mediated syncope. Am J Cardiol 1999;83(7):1059-1063. IF：3.905
147.Zeng C, Zhu Z, Liu G, Wang X, He D, Wang H, Yang C, Tan J. Inhibitory effect of enalapril on neurally mediated syncope in elderly patients. J Cardiovasc Pharmarcol 1998;31(4):638-642. IF：2.292
148.Zeng C, Zhu Z, Liu G, Hu W, Wang X, Yang C, Wang H, He D, Tan J. Randomized, double-blind, placebo-controlled trial of oral enalapril in patients with neurally mediated syncope. Am Heart J 1998;136(5):852-858. IF：4.285



知识产权
1. 曾春雨，韩愈，王震，陈垦，李郁。鸢尾素在制备预防心肌缺血再灌注损伤的药物中的应用。专利号：ZL8.2，2014-10-10(证书号 第**)。(Patent Cooperation Treaty, PCT/CN2014/080938)，IPC主分类号A61K 38/22(2006.01)
2. 曾春雨，韩愈，王震，陈垦，李郁。Irisin美国专利，专利号**，专利授权日期2017-06-20。Application of Irisinin myocardial ischemia reperfusion，IPC主分类号A61P9/10
3. 曾春雨，张晔，于长青，唐辉，李良鹏，陈垦。GRK4变异体和收缩压变化与尿钠排泄率比值的联合应用及方法，专利号ZL5.5，专利授权日期2018-07-06。IPC主分类号C12Q1/68(2006.01)I
4. 杨剑，曾春雨，周林，李晓龙。超声微泡介导的siRNA干扰GRK4在靶向调节尿钠排泄及血压水平中的应用。专利号ZL 2015 1 **.4，专利授权日期2018-05-1。IPC主分类号 C12N15/113(2010.01)I
5. 曾春雨，吴庚泽，余骏逸。可编码ArtRD蛋白基因及其蛋白和应用。专利号ZL4.5。申请日2017-02-17，授权公告日2019-8-30。IPC分类号C12N 15/12
6. 王伟，付文斌，廖巧，廖翔，杨德忠，曾春雨。二甲双胍联合成体干细胞在制备治疗心肌梗死药物中的应用。专利号ZL4.2。申请日2016-11-30，授权公告日2019-10-22。



著作教材
一、主编专著：
1. 曾春雨主编。高血压病学—从基础到临床，从指南到实践。科学出版社，2019-11。
二、参编著作：
1. 陈垦，曾春雨。肌源性因子与血压调节。见：高血压学；赵连友主编。科学出版社；2019-09。
2. 杨剑，曾春雨。多巴胺受体与原发性高血压。见：高血压学；赵连友主编。科学出版社；2019-09。
3. 陈垦，曾春雨。慢性肾脏病患者降压治疗优化策略。见：心脏病学实践2019（第一分册：心血管疾病预防、高血压、血脂异常）；顾东风、王继光、彭道泉主编。人民卫生出版社；2019。
4. 陈垦，曾春雨。高血压肾病的诊疗进展。P68-72.见：心脏病学实践2018；张健、陈义汉主编。人民卫生出版社；2018。
5. 李良鹏，王伟，曾春雨。轻链心肌淀粉样变性诊治进展。 P550-553。见：心脏病学实践2017；韩亚玲、张健主编。人民卫生出版社；2017年。
6. 张晔，曾春雨。高血压的个体化药物选择。 P87-97。见：心脏病学实践2016；马长生，韩亚玲主编。人民卫生出版社；2016年。
7. 曾春雨，方玉强。 急诊心律失常临床治疗热点浅析。 P200-203。见：心律失常的急诊处理；陈灿、黄石安主编。科学技术出版社；2014年。
8. 曾春雨，傅春江。 华法林的基因检测与个体化治疗。 P23-30。见：心脏病学实践2014；胡大一、马长生主编。人民卫生出版社；2014年。
9. 方玉强，曾春雨。非瓣膜病心房纤颤临床诊治进展；P150-162。见：心源性脑栓塞：临床防治进展；宋治远、张玉顺、陈康宁主编。军事医学科学出版社；2014年。
10. 曾春雨，傅春江。华法林的基因检测与个体化治疗。 P23-30。见：心脏病学实践2013；胡大一、马长生主编。人民卫生出版社；2014年。
11. 曾春雨。 多巴胺受体在高血压中的作用研究进展。 P377-385。见：中西医结合思考与实践；陈可冀主编。人民卫生出版社；2013年。
12. 曾春雨，方玉强。 CRP和纤维蛋白原与心血管风险评估-荟萃分析解读。 P622-631。见：心脏病学实践2013；胡大一、马长生主编。人民卫生出版社；2013年。
13. 曾春雨,傅春江。多巴胺受体：RAAS和交感神经系统升血压的重要制衡因素；P19-25。见：高血压诊治新进展（国家级继续医学教育项目教材）；孙宁玲、赵连友主编。人民军医出版社出版；2012年。
14. Zhang Y, Jose PA, Zeng C. Regulation of sodium transport in the proximal tubule by endothelin. P63-P75. In book named as “Endothelin in renal physiology and disease”. Editor: Matthias Barton and Donald E. Kohan. Published by Karger Co. 2011.
15. 曾春雨。一氧化氮与心血管疾病；P26-40。见：血管损伤性疾病-从分子到临床；黄岚、黄德嘉主编。人民卫生出版社出版；2008年。
16. 王旭开、杨立、张晔、曾春雨。血管病的临床现状; P1-64。见：实用血管内科学；王旭开、杨成明主编。四处科学技术出版社；2006年。
三、参编教材：
1. 王微，曾春雨。多巴胺受体与高血压；P3-10。见：高血压诊治新进展（国家级继续医学教育项目教材）；孙宁玲、赵连友主编。中华医学电子音像出版社出版；2014年。
2.刘莉，曾春雨。多巴胺受体与高血压；P18-23。见：高血压诊治新进展（国家级继续医学教育项目教材）；孙宁玲、赵连友主编。中华医学电子音像出版社出版；2013年。
3. 曾春雨,张晔。多巴胺受体在高血压中的作用研究进展；P48-58。见：高血压诊治新进展（国家级继续医学教育项目教材）；孙宁玲、赵连友主编。人民军医出版社出版；2011年。
4. 曾春雨,方玉强。合并冠心病的高血压患者血压控制策略；P221-227。见：高血压诊治新进展（国家级继续医学教育项目教材）；孙宁玲、林曙光、赵连友主编。中华医学电子音像出版社出版；2010年。
5. 曾春雨。肾素-血管紧张素-醛固酮系统在高血压发生、发展中的作用；P149-163。见：高血压（国家级继续医学教育项目教材）；刘国仗主编。中华医学电子音像出版社出版；2006年。
6. 曾春雨。血管紧张素转化酶抑制剂与Ang-(1-7)、Ang I(2-10); P69-74。见：高血压（国家级继续医学教育项目教材）；刘国仗、林曙光主编。中国协和医科大学出版社/中华医学电子音像出版社出版；2007年。



指导研究生情况(近五年)
近五年培养博士研究生35人，其中毕业16人；培养硕士研究生20人，其中毕业13人。
入选重庆市优博论文1篇，重庆市优硕论文1篇。

主讲课程
主讲硕士研究生课程：
生命科学综合III-疾病与防治（高血压病与动脉粥样硬化）




团队主要成员
刘志昭，副研究员
梁丽佳，特别助理研究员
段绪东，特别助理研究员
王瑜，特别助理研究员





研究方向
尚未录入;