贺耘 Title：教授，博导
E-mail Address：yun.he@cqu.edu.cn
Tel.：


个人/团队介绍

1991-1995美国雅培实验室药物化学家
2000-2002美国 Ionis制药公司药物化学主管
2002-2006美国诺华研究基金会基因研究所药物化学副总监
2006-2008罗氏研发中心 (中国) 有限公司药物化学高级总监
2008-2012保诺科技 (北京) 有限公司高级副总裁首席科学官
2012-现在 重庆大学教授、博导
2014-2021 重庆大学创新药物研究中心主任
2016-2021重庆大学药学院院长

学习工作经历 1981-1985 西南大学，获化学学士学位
1985-1988 兰州大学，获化学硕士学位（潘鑫复教授）
1988-1990 香港中文大学中化学系，攻读博士学位（黄乃正教授）
1990-1992 爱荷华州立大学，获化学硕士学位
1995-2000 斯克利普斯研究所，获有机化学博士学位


研究领域 （1）抗菌与抗癌新药的设计与合成
（2）天然产物全合成及生物活性研究
（3）药物靶向传输


项目成果
代表性文章 1. X. H. Yang, G. M. Shi, J. Guo, C. H. Wang, Y. He, “Exosome-Encapsulated Antibiotic Against Intracellular Infections of Methicillin-Resistant Staphylococcus Aureus (MRSA).” Int. J. Nanomed., 2018, 13, 8095-8104.
2. Z. H. Lin, X. B. Xu, S. Zhao, X. H. Yang, J. Guo, Q. Zhang, C. M. Jing, S. Chen and Y. He,“Total Synthesis and Antimicrobial Evaluation of Natural Albomycins against Clinical Pathogens.”Nat. Commun.,2018, 9, 3445.
3. B. Xu, Z. M. Yu, S. C. Xiang, Y. S. Li, S. L. Zhang, Y. He,“Rational Design of Mitochondria-targeted Pyruvate Dehydrogenase Kinase 1 Inhibitors with Improved Selectivity and Antiproliferative Activity.”Eur. J. Med. Chem.,2018, 155,275-284.
4. S. L. Zhang, Y. He, K. Y. Tam,“Targeting Cancer Metabolism to Develop Human Lactate Dehydrogenase 5 (HLDH5) Inhibitors.”Drug Discovery Today,2018,23, 1407-1415.
5. N. Zhang, Z. M.Yu, X. H. Yang, P. Hu, Y. He,“Synthesis of Novel Ring-contracted Artemisinin Dimers with Potent Anticancer Activities”,Eur. J. Med. Chem.,2018,150, 829-840.
6. A. Yesu, X. H.Yang, M.H.Zhou, P. R. Devi, S. L. Zhang, Z. Wang, Y. He,“Synthesis and Anticancer Activity Evaluation of Novel Azacalix[2]arene[2]pyrimidines.” Eur. J. Med. Chem.,2018,151, 214-225.
7. P. R. Devi;N. Zhang;Z.M.Yu;Z. Wang;Y.He,“Total Synthesis of Kanamienamide.”J. Org. Chem.,2017,82, 11262–11268.
8. B. Sreenivas, P. R. Devi, W. X. Li, C. H. Wang, J. Guo, Y. He, “A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G.” Org. Lett.,2017, 19, 4996–4999.
9. Q. Liu, P. Hu and Y. He, “Asymmetric Total Synthesis of Nannocystin A.”J. Org. Chem.,2017,82, 9217–9222.
10. M.Q. Tang; P. Hu; Q. Zheng; N. Tirelli; X. H.Yang; Z. L.Wang; Y. F.Wang; Q. Tang; Y. He,“Polymeric Micelles with Dual Thermal and Reactive Oxygen Species (ROS)-Responsiveness for Inflammatory Cancer Cell Delivery.” J. Nanobiotechnology,2017,15,39.
11. Q. Zheng, P. Hu, Q. Tang, M. Q. Tang, Z. L. Zang, P. L. Shao, Z. Wang, Y. He, “Dually Responsive Amphiphilic Block Copolymer with Oxidation-Responsiveness and Tuneable LCST Behaviours” Materials Letters. 2017, 201, 133-136.
12. Z. L. Zang, S. Zhao, S. Karnakanti, C. L. Liu, P. L. Shao and Y. He, “Catalytic Multisite-Selective Acetoxylation Reactions at sp2 vs sp3 C–H Bonds in Cyclic Olefins.” Org. Lett. 2016, 18, 5014–5017.
13. N. Qi, S. R. Allu, Z. L. Wang, Q. Liu, J. Guo, and Y. He, “Asymmetric Total Syntheses of Aetheramides and Their Stereoisomers: Stereochemical Assignment of Aetheramides.” Org. Lett. 2016, 18, 4718–4721.
14. R. S Reddy, C. Lagishetti, I. N. C Kiran, H. Y. You, and Y. He, “Transition-Metal-Free Cascade Synthesis of 4-Quinolones: Umpolung of Michael Acceptors via Ene Reaction with Arynes.” Org. Lett. 2016, 18, 3818–3821.
15. J. Guo, I. N. C Kiran, R. S Reddy, J. S. Gao, M. Q. Tang, Y. Y. Liu, and Y. He, “Synthesis of Carbazolequinones by Formal [3 + 2] Cycloaddition of Arynes and 2-Aminoquinones.” Org. Lett. 2016, 18, 2499–2502.
16. Y. He, P. K. Agarwal, I. N. C Kiran, R. C. Yu, B. Cao, C Zou, X. H. Zhou, H. C. Xu, B. Xu, L. Zhu, Y. Lan, K. C. Nicolaou, “Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones.” Chem. Eur. J. 2016, 22, 7696–7701.
17. J. C. Wong, G. Tang, X. Wu, C. Liang, Z. Zhang, L. Guo, Z. Peng, W. Zhang, X. Lin, Z. Wang, J. Mei, J. Chen,S. Pan, N. Zhang, Y. Liu, M. Zhou, L. Feng, Weili Zhao, S. Li, C. Zhang, M. Zhang, Y. Rong, T. Jin, X. Zhang, S. Ren, Ying Ji, R. Zhao, J. She, Y. Ren, C. Xu, D. Chen, J. Cai, S. Shan, D. Pan, Z. Ning, X. Lu, T. Chen, Y. He, L. Chen. "Pharmacokinetic Optimization of Class-Selective Histone Deacetylase Inhibitors and Identification of Associated Candidate Predictive Biomarkers of Hepatocellular Carcinoma Tumor Response." J. Med. Chem. 2012, 55, 8903-8925.
18. G. Zhang, P. Ren, N.S. Gray, T. Sim, X. Wang, Y. Liu, J. Che, W. Dong, S.S. Tian, M.L. Sandberg, T.A. Spalding, R. Romeo, M. Iskandar, Z. Wang, M.H. Seidel, D.S. Karanewsky, Y. He, “Discovery of Pyrimidine Benzimidazoles as Src-family Selective Lck Inhibitors. Part II.” Bioorg. Med. Chem. Lett. 2009, 19, 6691.
19. B. Wu, K. Kuhen, T. N. Nguyen, D. Ellis, B. Anaclerio, X. He, K. Yang, D. Karanewsky, H. Yin, K. Wolff, K. Bieza, J. Caldwell, Y. He, "Synthesis and Evaluation of N-Aryl Pyrrolidinones as Novel Anti-HIV-1 Agents. Part 1." Bioorg. Med. Chem. Lett. 2006, 16, 3430-3433.
20. Y. He, J, Yang, B. Wu, D. Robinson, K. Sprankle, P.-P. Kung, K. Lowery, V. Mohan, S. Hofstadler, E. E. Swayze, R. Griffey, “Synthesis and Evaluation of Novel Bacterial rRNA-binding Benzimidazoles by Mass Spectrometry.” Bioorg. Med. Chem. Lett. 2004, 14, 695-699.
21. K.C. Nicolaou, Y. He, D. Vourloumis, H. Vallberg, F. Roschangar, F. Sarabia, S. Ninkovic, Z. Yang, “The Olefin Metathesis Approach to Epothilone A and Its Analogs.” J. Am. Chem. Soc. 1997, 119, 7960-7973.