2004-2010年 中国科学院生物物理研究所 博士
2010-2013年 美国德州大学安德森癌症中心 博士后
2013-至今 清华大学医学院 副研究员
研究领域与方向 1. 真菌等病原微生物感染过程中固有免疫应答的分子机制；
2. CAR-T、TCR-T等细胞免疫治疗技术在肿瘤治疗中的应用研究。
学术荣誉与奖励
关键词真菌免疫、肿瘤免疫治疗
代表性论文1. Zhang S, Pan D, Jia X, Lin X, Zhao X. The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-kB activation and cell survival. Protein Cell. 2017 Nov; 8(11):856-860.
2. Zhao X, Guo Y, Jiang C, Chang Q, Zhang S, Luo T, Zhang B, Jia X, Hung MC, Dong C, Lin X. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. Nat Med. 2017 Mar; 23(3):337-346.
3. Zhao X, Zhu L, Chang Q, Jiang C, You Y, Luo T, Jia X, Lin X. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-kB activation. J Biol Chem. 2014 Oct 24; 289(43):30052-62.
4. Zhu L, Zhao X, Jiang C, You Y, Chen X, Jiang Y, Jia X, Lin X. C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity. 2013 Aug 22; 39(2):324-34.
5. Zhao X, Rong L, Zhao X, Li X, Liu X, Deng J, Wu H, Xu X, Erben U, Wu P, Syrbe U, Sieper J, Qin Z. TNF signaling drives myeloid-derived suppressor cell accumulation. J Clin Invest. 2012 Nov; 122(11):4094-104.
6. Zhao X, Mohaupt M, Jiang J, Liu S, Li B, Qin Z. Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis. Cancer Res. 2007 May 1; 67(9):4443-50.
联系方式Email: zhaoxueqiang at tsinghua.edu.cn
Phone: 86-
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