2014-至今: 高级工程师，清华大学
2008-2014: 工程师，清华大学
2002-2008: 初级工程师，清华大学
1999-2002: 硕士，西北农林科技大学
1994-1999: 学士，西北农业大学
研究领域与方向 肿瘤发生与信号通路 ?
学术荣誉与奖励
关键词信号转导, 癌症
代表性论文1.Jiao Liang, Ying Qiu, Yinyin Wang, Fangli Ren, Zhijie Chang*. CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical outcome. Int J Clin Exp Pathol 2017;10(2):2030-2035.
2. Yu Shang, Jinjun He, Yinyin Wang, Quanling Feng, Yanquan Zhang, Junwei Guo, Jun Li, Shan Li, Yangmeng Wang,Ge Yan, Fangli Ren,Yuguang Shi, Jiake Xu,Nikolajs Zeps,Yonggong Zhai,Dacheng He, and Zhijie Chang*.CHIP/Stub1 Regulates the Warburg Effect by Promoting Degradation of PKM2 in Ovarian Carcinoma. Oncogene. 36(29):4191-4200, Jul 20, 2017.
3. Fangli Ren, Yongtao Geng, Takayuki Minami, Ying Qiu, Yarui Feng, Chunxiao Liu, Juan Zhao, Yinyin Wang, Xuanzi Fan, Yangmeng Wang, Mengdi Li, Jun Li*, and Zhijie Chang*. Nuclear termination of STAT3 signaling through the SIPAR (STAT3-Interacting Protein As a Repressor) adaptor recruiting T cell tyrosine phosphatase TC-PTP. FEBS Letters. Jul 8;589(15):1890-6 2015.
4.Chunxiao Liu, Yanquan Zhang, Jun Li, Yinyin Wang, Fangli Ren, Yifan Zhou, Yinyuan Wu, Yarui Feng, Yu Zhou, Fuqin Su, Baoqing Jia, Dong Wang, and Zhijie Chang*. p15RS(p15INK4b Related Sequence)/RPRD1A (Regulation of Nuclear Pre-mRNA Domain-Containing Protein 1A) Interacts with HDAC2 (Histone Deacetylase 2) in Inhibition of the Wnt/b-catenin Signaling Pathway. J. Biol. Chem. Feb 19. pii: jbc.M114.620872, 2015.
5.Shigao Yang, Yinyin Wang, Kunrong Mei, Sen Zhang, Xiaojun Sun, Fangli Ren, Sihan Liu, Zi Yang, Xinquan Wang, Zhihai Qin, Zhijie Chang*. TNFR2–IL-17RD heteromerization reveals a novel mechanism for NF-κB activation. J. Biol. Chem. 2015 Jan 9;290(2):861-71. doi:10.1074/jbc.M114.586560. Epub 2014 Nov 5.
6.Fangli Ren, Ruoke Wang, Yanquan Zhang, Chunxiao Liu, Yinyin Wang, Jim Hu, Linqi Zhang, and Zhijie Chang*. Characterization of a Monoclonal Antibody Against CREPT, a Novel Protein Highly Expressed in Tumors. Monoclon Antib Immunodiagn Immunother. 33(6): 401–408, 2014.
7.Yanquan Zhang, Chunxiao Liu, Xiaolin Duan, Fangli Ren, Zhe Jin, Shan Li, Yinyin Wang, Yarui Feng, Zewen Liu and Zhijie Chang*.CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the b-catenin/TCF4 Transcriptional Activity in Response to Wnt Signaling. J. Biol. Chem. 289(33):22589-99, 2014.
8. Yangmeng Wang, Hongxiu Ning, Fangli Ren, Yuanjiang Zhang, Yu Rong, Yinyin Wang, Fuqin Su, Chenguang Cai, Zhe Jin, Zhiyong Li, Xinqi Gong, Yonggong Zhai, Dianjun Wang, Baoqing Jia, Ying Qiu, et.al, Xinyuan Fu, Y. Eugene Chin, and Zhijie Chang. GdX/UBL4A Specifically Stabilizes the TC45/STAT3 Association and Promotes Dephosphorylation of STAT3 to Repress Tumorigenesis. Mol. Cell. 53:752-765, 2014. (co-first author)
9. Yangmeng Wang, Fangli Ren, Yinyin Wang, Yarui Feng, Dianjun Wang, Baoqing Jia, Ying Qiu, Shiyan Wang, Jun Yu, Joseph JY Sung, Jiake Xu, Nikolajs Zeps, and Zhijie Chang*. CHIP/Stub1 functions as a tumor suppressor and represses NF-κB-mediated signaling in colorectal cancer. Carcinogenesis. 2014 May;35(5):983-91.
10. Yongtao Geng, Yanfang Ju, Fangli Ren, Ying Qiu, Yasuhiko Tomita, Miki Tomoeda, Mioka Kishida, Yinyin Wang, Lian Jin, Fuqin Su, Chunhong Wei, Baoqing Jia, Yi Li1*, Zhijie Chang*. Insulin Receptor Substrate 1/2 (IRS1/2) Regulates Wnt/β-catenin Signaling through Blocking Autophagic Degradation of Dishevelled2. J. Biol. Chem. 289( 16), 11230–11241, 2014.
11.Mei KunRong, Jin Zhe, Ren Fangli, Wang Yinyin, Chang Zhijie*, Wang Xinquan*. Structure basis for the recognition of RNA polymerase II C-terminal domain by CREPT and p15RS. Science China Life Sciences Volume 57, Number 1:97-106, 2014.
12.Shan Li, Bing Shu, Yanquan Zhang, Jia Li, Junwei Guo, Yinyin Wang, Fangli Ren, Guozhi Xiao, Zhijie Chang*, and Di Chen*. CHIP Regulates Osteoclast Formation through Promoting TRAF6 Protein Degradation. Arthritis & Rheumatology. 2014, Jul;66(7):1854-63.
13.Yu Shang, Xinghui Zhao, Bo Tian, Yinyin Wang, Fangli Ren, Baoqing Jia, Yonggong Zhai, Dacheng He, Wei Chen and Zhijie Chang. CHIP/Stub1 interacts with eIF5A and mediates its degradation. Cellular Signalling. 2014, May;26(5):1098-104.
14.Fangli Ren, Fuqin Su, Hongxiu Ning, Yangmeng Wang, Yongtao Geng, Yarui Feng, Yinyin Wang, Yanquan Zhang, Zhe Jin, Yi Li, Baoqing Jia and Zhijie Chang*. SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. Cellular Signalling. 25:2272-2280, 2013.
15.Xiaojun Sun, Yinyin Wang, Shigao Yang, Fangli Ren, Yongjing Xia, Zhijie Chang*. Activation of TAK1 by Sef-S induces apoptosis in 293T cells. Cellular Signalling. 25:2039-2046, 2013.
16.Dongdong Lu, Yinyuan Wu, Yinyin Wang, Fangli Ren, Dianjun Wang, Fuqin Su, Yanquan Zhang, Xi Yang, Guihua Jin, Xinbao Hao, et.al, Jim Hu, Joseph JY Sung, Jun Yu, Baoqing Jia*, Zhijie Chang*. CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle related genes. Cancer Cell, 21:92-104, 2012.(co-first author)
17.Fuqin Su, Fangli Ren, Yu Rong, Yangmeng Wang, Yongtao Geng, Yinyin Wang, Mengyao Feng, Yanfang, Ju Yi Li, Zhizhuang J. Zhao, Kun Meng*, Zhijie Chang*. Protein tyrosine phosphatase Meg2 dephosphorylates STAT3 and suppresses tumor growth in the breast cancer. Breast Cancer Research. 2012 Mar 6;14(2):R38.
18.Junwei Guo, Fangli Ren, Yinyin Wang, Shan Li, Zhengrong Gao, Xiaoyan Wang, Hongxiu Ning, Jianguo Wu, Yi Li, Zhao Wang, Shek Man Chim, Jiake Xu, and Zhijie Chang*. miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. Journal of Bone and Mineral Research 2012 Mar 9. doi: 10.1002/jbmr.1597.
19.Yangmeng Wang, Dianjun Wang, Fangli Ren, Yuanjiang Zhang, Fuyu Lin, Ning Hou, Xuan Cheng, Peng Zhang, Yinyin Wang, Baoqing Jia, Xiao Yang and Zhijie Chang*. Generation of mice with conditional null allele for GdX/Ubl4A. Genesis, 50:534-542, 2012.
20.Yanquan Zhang, Fang Wang, Liang Han, Yinyuan Wu, Shan Li, Xi Yang, Yinyin Wang, Fangli Ren, Yonggong Zhai, Dianjun Wang, Baoqing Jia, Yongjing Xia, and Zhijie Chang*. GABARAPL1 negatively regulates Wnt/?-catenin pathway by mediating Dvl2 degradation through autophagy pathway. Cellular Physiology and Biochemistry. 27:503-512, 2011.
21.Yinyuan Wu, Dianjun Wang, Yinyin Wang, Fangli Ren, Donald Chang, Zhijie Chang* and Baoqing Jia*. Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells. Cellular Physiology and Biochemistry. 27:539-546, 2011.
22.Xinbao Hao,Yinyin Wang, Fangli Ren, Shanshan Zhu, Yongming Ren, Baoqing Jia, Yi-Ping Li, Yuguang Shi and Zhijie Chang*. SNX25 regulates TGF-β signaling by enhancing the receptor degradation. Cellular Signalling. 23(5):935-946, 2011.
23.Yinyuan Wu, Yanquan Zhang, Haiwei Zhang, Xi Yang, Yinyin Wang, Fangli Ren, Huitu Liu, Yonggong Zhai, Baoqing Jia, Jun Yu, and Zhijie Chang*. p15RS attenuates Wnt/β-catenin signaling by disrupting β-catenin/TCF4 interaction. J. Biol. Chem. 285(45):34621-34631, 2010.
24.Zhen Qin, Fangli Ren, Xialian Xu, Yongming Ren, Hongge Li, Yinyin Wang, Yonggong Zhai, and Zhijie Chang*. ZNF536, A Novel Zinc Finger Protein Specifically Expressed In The Brain, Negatively Regulates Neuron Differentiation Via Repressing RA-Induced Gene Transcription. Mol. Cell. Biol. 29:3633-43, 2009.
25.Zhili Rong, Andrew Wang, Zhiyong Li, Yongming Ren, Long Cheng, Yinghua Li, Yinyin Wang, Fangli Ren, Xiaoning Zhang, Jim Hu and Zhijie Chang*. IL-17RD (Sef or IL-17RLM) Interacts with IL-17 Receptor and Mediates IL-17 Signaling. Cell Research. 19:208-215, 2009.
26.Xueni Li, Mei Huang, Huiling Zheng, Yinyin Wang, Fangli Ren, Yu Shang, Yonggong Zhai, David M. Irwin, Yuguang Shi, Di Chen, and Zhijie Chang*. CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. Journal of Cell Biology. 181(6):959-972, 2008.
联系方式Email: rfl at tsinghua.edu.cn
Phone: +86-
个人主页
