2001年7月-2003年10月 清华大学生物科学与技术系，初级工程师
1998年9月-2001年7月 西北农林科技大学农学系，硕士
研究领域与方向 肿瘤基因，信号转导，蛋白降解，蛋白修饰，转录调控 肿瘤相关基因的功能与机制研究
学术荣誉与奖励1. Xuanzi Fan#, Juan Zhao#, Fangli Ren, Yinyin Wang, Yarui Feng, Lidan Ding, Linpeng Zhao, Jun Li, Jianquan Ni, Baoqing Jia, Zhijie Chang*. Dimerization of p15RS mediated by a leucine-zipper-like motif is critical for its inhibitory role on Wnt signaling. J Biol Chem, Accepted, 2018.
2. Yanquan Zhang, Shiyan Wang, Wei Kang, Chunxiao Liu, Yujuan Dong, Fangli Ren, Yinyin Wang, Jinglin Zhang, Guoping Wang, Ka-Fai To, Xueji Zhang, Joseph Sung, and Zhijie Chang*, Jun Yu*. CREPT facilitates colorectal cancer growth through inducing Wnt/b-catenin pathway by enhancing p300-mediated b-catenin acetylation. Oncogene, Accepted, 2018
3. Liang, Jiao(#); Li, Jun; Fu, Yanxia; Ren, Fangli; Xu, Jiake; Zhou, Mengyu; Li, Peiyu(*); Feng, Haotian(*); Wang, Yinyin(*), GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis. Cell Biochem Funct, 2018.2.20, 36: 1~8 （通讯作者）
4. Shang, Y.(#); He, J.; Wang, Y.; Feng, Q.; Zhang, Y.; Guo, J.; Li, J.; Li, S.; Wang, Y.; Yan, G.; Ren, F.; Shi, Y.; Xu, J.; Zeps, N.; Zhai, Y.; He, D.; Chang, Z.(*), CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma, ONCOGENE, 2017.7.20, 36(29): 4191~4200
5. Liang, Jiao(#); Qiu, Ying; Wang, Yinyin; Ren, Fangli; Chang, Zhijie(*), CREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical outcome, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10(2): 2030~2035
6. Kuang, Yan-Shen(#); Wang, Yi(#); Ding, Li-Dan; Yang, Liu; Wang, Ying; Liu, Si-Han; Zhu, Bing-Tao; Wang, Xu-Ning; Liu, Hong-Yi; Li, Jun; Chang, Zhi-Jie; Wang, Yin-Yin; Jia, Bao-Qing(*), Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil. World J Gastroenterol, 2018.1.28, 24(4): 475~483
7. Li, Chunlei(#); Fu, Yanxia; Wang, Yinyin; Kong, Yanhua; Li, Mengdi; Ma, Danhui; Zhai, Wanli; Wang, Hao; Lin, Yuting; Liu, Sihan; Ren, Fangli; Li, Jun; Wang, Yi(*), Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats., Cell Biochem Funct, 2017.10, 35(7): 420~425
8. Yang, Shigao(#); Wang, Yinyin(#); Mei, Kunrong; Zhang, Sen; Sun, Xiaojun; Ren, Fangli; Liu, Sihan; Yang, Zi; Wang, Xinquan; Qin, Zhihai; Chang, Zhijie(*), Tumor necrosis factor receptor 2 (TNFR2).interleukin-17 receptor D (IL-17RD) heteromerization reveals a novel mechanism for NF-kappaB activation., J Biol Chem, 2015.1.9, 290(2): 861~871 （共同第一作者）
9. Liu, Chunxiao(#); Zhang, Yanquan; Li, Jun; Wang, Yinyin; Ren, Fangli; Zhou, Yifan; Wu, Yinyuan; Feng, Yarui; Zhou, Yu; Su, Fuqin; Jia, Baoqing; Wang, Dong; Chang, Zhijie(*), p15RS/RPRD1A (p15INK4b-related sequence/regulation of nuclear pre-mRNA domain-containing protein 1A) interacts with HDAC2 in inhibition of the Wnt/beta-catenin signaling pathway. J Biol Chem, 2015.4.10, 290(15): 9701~9713
10. Ren, Fangli(#); Geng, Yongtao; Minami, Takayuki; Qiu, Ying; Feng, Yarui; Liu, Chunxiao; Zhao, Juan; Wang, Yinyin; Fan, Xuanzi; Wang, Yangmeng; Li, Mengdi; Li, Jun(*); Chang, Zhijie(*), Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. FEBS Lett, 2015.7.8, 589(15): 1890~1896
11. Xiao, Kang(#); Wang, Yinyin; Chang, Zhijie; Lao, Yuanzhi(*); Chang, Donald C(*), p32, a novel binding partner of Mcl-1, positively regulates mitochondrial Ca(2+) uptake and apoptosis., Biochem Biophys Res Commun, 2014.8.22, 451(2): 322~328
12. Ren, Fangli(#); Wang, Ruoke; Zhang, Yanquan; Liu, Chunxiao; Wang, Yinyin; Hu, Jim; Zhang, Linqi; Chang, Zhijie(*), Characterization of a monoclonal antibody against CREPT, a novel protein highly expressed in tumors., Monoclon Antib Immunodiagn Immunother, 2014.12.01, 33(6): 401~408
13. Zhang, Yanquan(#); Liu, Chunxiao; Duan, Xiaolin; Ren, Fangli; Li, Shan; Jin, Zhe; Wang, Yinyin; Feng, Yarui; Liu, Zewen; Chang, Zhijie(*), CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the beta-catenin.TCF4 transcriptional activity in response to Wnt signaling. J Biol Chem, 2014.8.15, 289(33): 22589~22599
14. Li, Shan(#); Shu, Bing; Zhang, Yanquan; Li, Jia; Guo, Junwei; Wang, Yinyin; Ren, Fangli; Xiao, Guozhi; Chang, Zhijie(*); Chen, Di(*), Carboxyl terminus of Hsp70-interacting protein regulation of osteoclast formation in mice through promotion of tumor necrosis factor receptor-associated factor 6 protein degradation. Arthritis Rheumatol, 2014.7.01, 66(7): 1854~1863
15. Qi, Huabing(#); Jin, Min; Duan, Yaqi; Du, Xiaolan; Zhang, Yuanquan; Ren, Fangli; Wang, Yinyin; Tian, Qingyun; Wang, Xiaofeng; Wang, Quan; Zhu, Ying; Xie, Yangli; Liu, Chuanju; Cao, Xu; Mishina, Yuji; Chen, Di; Deng, Chu-xia; Chang, Zhijie(*); Chen, Lin(*), FGFR3 induces degradation of BMP type I receptor to regulate skeletal development. Biochim Biophys Acta, 2014.7, 1843(7): 1237~1247
16. Wang, Yangmeng(#); Ren, Fangli; Wang, Yinyin; Feng, Yarui; Wang, Dianjun; Jia, Baoqing; Qiu, Ying; Wang, Shiyan; Yu, Jun; Sung, Joseph Jy; Xu, Jiake; Zeps, Nikolajs; Chang, Zhijie(*), CHIP/Stub1 functions as a tumor suppressor and represses NF-kappaB-mediated signaling in colorectal cancer. Carcinogenesis, 2014.5.01, 35(5): 983~991
17. Shang, Yu(#)(*); Zhao, Xinghui; Tian, Bo; Wang, Yinyin; Ren, Fangli; Jia, Baoqing; Zhai, Yonggong; Chen, Wei; He, Dacheng; Chang, Zhijie(*), CHIP/Stub1 interacts with eIF5A and mediates its degradation. Cell Signal, 2014.5, 26(5): 1098~1104
18. Geng, Yongtao(#); Ju, Yanfang; Ren, Fangli; Qiu, Ying; Tomita, Yasuhiko; Tomoeda, Miki; Kishida, Mioka; Wang, Yinyin; Jin, Lian; Su, Fuqin; Wei, Chunhong; Jia, Baoqing; Li, Yi; Chang, Zhijie(*), Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/beta-catenin signaling through blocking autophagic degradation of dishevelled2. J Biol Chem, 2014.4.18, 289(16): 11230~11241
19. Shang, Yu(#); Xu, Xialian; Duan, Xiaolin; Guo, Junwei; Wang, Yinyin; Ren, Fangli; He, Dacheng; Chang, Zhijie(*), Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1. Biochem Biophys Res Commun, 2014.3.28, 446(1): 387~392
20. Mei KunRong; Jin Zhe; Ren FangLi; Wang YinYin; Chang ZhiJie(*); Wang XinQuan(*), Structural basis for the recognition of RNA polymerase II C-terminal domain by CREPT and p15RS Science China Life Sciences, 2014.1, 57(1): 97~106
21. Wang, Yangmeng(#); Ning, Hongxiu; Ren, Fangli; Zhang, Yuanjiang; Rong, Yu; Wang, Yinyin; Su, Fuqin; Cai, Chenguang; Jin, Zhe; Li, Zhiyong; Gong, Xinqi; Zhai, Yonggong; Wang, Dianjun; Jia, Baoqing; Qiu, Ying; Tomita, Yasuhiko; Sung, Joseph J Y; Yu, Jun; Irwin, David M; Yang, Xiao; Fu, Xinyuan; Chin, Y Eugene(*); Chang, Zhijie(*), GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis. Mol Cell, 2014.3.6, 53(5): 752~765
22. She, Yaoguang(#); Liang, Jiao; Chen, Lin; Qiu, Ying; Liu, Na; Zhao, Xudong; Huang, Xiaohui; Wang, Yinyin; Ren, Fangli; Chang, Zhijie; Li, Peiyu(*), CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma., Int J Clin Exp Pathol, 2014.01.01, 7(10): 6596~6605
23. Sun, Xiaojun(*); Wang, Yinyin; Yang, Shigao; Ren, Fangli; Xia, Yongjing; Chang, Zhijie(*), Activation of TAK1 by Sef-S induces apoptosis in 293T cells, Cellular Signalling, 2013.10, 25(10): 2039~2046
24. Ren, Fangli(#); Su, Fuqin; Ning, Hongxiu; Wang, Yangmeng; Geng, Yongtao; Feng, Yarui; Wang, Yinyin; Zhang, Yanquan; Jin, Zhe; Li, Yi; Jia, Baoqing; Chang, Zhijie(*), SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. Cell Signal, 2013.11.01, 25(11): 2272~2280
25. Lu, Dongdong(#); Wu, Yinyuan(#); Wang, Yinyin(#); Ren, Fangli(#); Wang, Dianjun; Su, Fuqin; Zhang, Yanquan; Yang, Xi; Jin, Guihua; Hao, Xinbao; He, Dacheng; Zhai, Yonggong; Irwin, David M.; Hu, Jim; Sung, Joseph J. Y.; Yu, Jun; Jia, Baoqing(*); Chang, Zhijie(*), CREPT Accelerates Tumorigenesis by Regulating the Transcription of Cell-Cycle-Related Genes, Cancer Cell, 2012.1.17, 21(1): 92~104
(共同第一作者)
26. Wang, Yangmeng(#); Wang, Dianjun; Ren, Fangli; Zhang, Yuanjiang; Lin, Fuyu; Hou, Ning; Cheng, Xuan; Zhang, Peng; Wang, Yinyin; Jia, Baoqing; Yang, Xiao; Chang, Zhijie(*), Generation of mice with conditional null allele for GdX/Ubl4A, Genesis, 2012.7.01, 50(7): 534~542
27. Yang, Xi(#); Zhang, Yanquan; Li, Shan; Liu, Chunxiao; Jin, Zhe; Wang, Yinyin; Ren, Fangli; Chang, Zhijie(*), Rab21 attenuates EGF-mediated MAPK signaling through enhancing EGFR internalization and degradation. Biochemical and Biophysical Research Communications, 2012.5.18, 421(4): 651~657
28. Su, Fuqin(#); Ren, Fangli; Rong, Yu; Wang, Yangmeng; Geng, Yongtao; Wang, Yinyin; Feng, Mengyao; Ju, Yanfang; Li, Yi; Zhao, Zhizhuang J.; Meng, Kun(*); Chang, Zhijie(*), Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer, Breast Cancer Research, 2012.01.01, 14(2)
29. Guo, Junwei(#); Ren, Fangli; Wang, Yinyin; Li, Shan; Gao, Zhengrong; Wang, Xiaoyan; Ning, Hongxiu; Wu, Jianguo; Li, Yi; Wang, Zhao; Chim, Shek Man; Xu, Jiake; Chang, Zhijie(*), miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression, Journal of Bone and Mineral Research, 2012.7.01, 27(7): 1607~1618
30. Hao, Xinbao(#); Wang, Yinyin(#); Ren, Fangli; Zhu, Shanshan; Ren, Yongming; Jia, Baoqing; Li, Yi-Ping; Shi, Yuguang; Chang, Zhijie(*), SNX25 regulates TGF-beta signaling by enhancing the receptor degradation, Cellular Signalling, 2011.5.01, 23(5): 935~946 (共同第一作者)
31. Wu, Yinyuan(#); Wang, Dianjun; Wang, Xiaodong; Wang, Yinyin; Ren, Fangli; Chang, Donald; Chang, Zhijie(*); Jia, Baoqing(*), Caspase 3 is Activated through Caspase 8 instead of Caspase 9 during H2O2-induced Apoptosis in HeLa Cells, Cellular Physiology and Biochemistry, 2011.01.01, 27(5): 539~546
32. Zhang, Yanquan(#); Wang, Fang; Han, Liang; Wu, Yinyuan; Li, Shan; Yang, Xi; Wang, Yinyin; Ren, Fangli; Zhai, Yonggong; Wang, Dianjun; Jia, Baoqing; Xia, Yongjing; Chang, Zhijie(*), GABARAPL1 Negatively Regulates Wnt/beta-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway, Cellular Physiology and Biochemistry, 2011.01.01, 27(5): 503~512
33. Zhang, Haiwei(#); Zhang, Hui; Zhang, Yanquan; Ng, Ser Sur; Ren, Fangli; Wang, Yinyin; Duan, Yaqi; Chen, Lin; Zhai, Yonggong; Guo, Qinglong; Chang, Zhijie(*), Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/beta-catenin complex., Cell Signal, 2010.11, 22(11): 1753~1760
34. Wu, Yinyuan(#); Zhang, Yanquan; Zhang, Haiwei; Yang, Xi; Wang, Yinyin; Ren, Fangli; Liu, Huitu; Zhai, Yonggong; Jia, Baoqing; Yu, Jun; Chang, Zhijie(*), p15RS Attenuates Wnt/beta-Catenin Signaling by Disrupting beta-Catenin.TCF4 Interaction, Journal of Biological Chemistry, 2010.11.5, 285(45): 34621~34631
35. Wu, Yinyuan(#); Wang, Yinyin; Sun, Yang; Zhang, Liying; Wang, Dianjun; Ren, Fangli; Chang, Donald; Chang, Zhijie(*); Jia, Baoqing(*), RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL, Cellular Signalling, 2010.10.01, 22(10): 1495~1501
36. Li, Ying-Hua(#); Wang, Yin-Yin; Zhong, Shan; Rong, Zhi-Li; Ren, Yong-Ming; Li, Zhi-Yong; Zhang, Shu-Ping; Chang, Zhi-Jie; Liu, Li(*), Transmembrane Helix of Novel Oncogene with Kinase-Domain (NOK) Influences Its Oligomerization and Limits the Activation of RAS/MAPK Signaling, Molecules and Cells, 2009.1.01, 27(1): 39~45
37. Qin, Zhen(#); Ren, Fangli; Xu, Xialian; Ren, Yongming; Li, Hongge; Wang, Yinyin; Zhai, Yonggong; Chang, Zhijie(*), ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription, Molecular and Cellular Biology, 2009.7.1, 29(13): 3633~3643
38. Rong, Zhili(#); Wang, Anan; Li, Zhiyong; Ren, Yongming; Cheng, Long; Li, Yinghua; Wang, Yinyin; Ren, Fangli; Zhang, Xiaoning; Hu, Jim; Chang, Zhijie(*), IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling, Cell Research, 2009.2.01, 19(2): 208~215
39. Wang, Fang(#); Zhang, Haiwei; Zhang, Xinjun; Wang, Yinyin; Ren, Fangli; Zhang, Xiaoning; Zhai, Yonggong; Chang, Zhijie(*), Varp interacts with Rab38 and functions as its potential effector, Biochemical and Biophysical Research Communications, 2008.7.18, 372(1): 162~167
40. Li, Xueni(#); Huang, Mei(#); Zheng, Huiling(#); Wang, Yinyin; Ren, Fangli; Shang, Yu; Zhai, Yonggong; Irwin, David M.; Shi, Yuguang; Chen, Di; Chang, Zhijie(*), CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation, The Journal of Cell Biology, 2008.6.16, 181(6): 959~972
41. Li, T(#); Zhang, Y; Fu, L; Yu, C; Li, X; Li, Y; Zhang, X; Rong, Z; Wang, Y; Ning, H; Liang, R; Chen, W; Babiuk, LA; Chang, Z(*), siRNA targeting the Leader sequence of SARS-CoV inhibits virus replication, GENE THERAPY, 2005.5, 12(9): 751~761
42. Xin, H(#); Xu, XL; Li, LY; Ning, HX; Rong, Y; Shang, Y; Wang, YY; Fu, XY; Chang, ZJ(*), CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation, Journal of Biological Chemistry, 2005.5.27, 280(21): 20842~20850
43. Zhang, YJ(#); Li, TS; Fu, L; Yu, CM; Li, YH; Xu, XL; Wang, YY; Ning, HX; Zhang, SP; Chen, W; Babiuk, LA; Chang, ZJ(*), Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference, FEBS LETTERS, 2004.2.27, 560(1-3): 141~146
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