高丹讲师 电话：　　
邮箱：gao.dan@sz.tsinghua.edu.cn办公地址：
所属学科：化学生物学

【个人简历】
2002年9月-2006年6月 北京服装学院 应用化学专业 本科
2006年9月-2011年6月 北京化工大学与清华大学联合培养 化学工程与技术 博士
2011年7月-2013年6月 清华大学深圳研究生院 分析化学 博士后
2013年8月至今 清华大学深圳研究生院 讲师
【研究领域】
研究方向为生命分析化学，以新型的微流控芯片技术与微液滴技术为特色，结合液质联用技术，建立了具有显著生物医学特色的功能化微流控系统、化学反应新技术和组学分析新方法，应用于新药临床前评价、疾病早期诊断与新型化学反应及机制探索等众多领域。作为项目负责人主持国家自然科学基金面上项目、青年基金，中国博士后基金、广东省自然科学基金项目、深圳市基础研究学科布局、基础研究自由探索等多个项目；作为项目骨干参与新药创制重大专项、973项目、863计划等多个项目，在国际著名学术期刊发表SCI科研论文40余篇。
【论文与专利】
[1]Ning Wang, Shaopeng Chen, Bin Zhang, Shangfu Li, Feng Jin, Dan Gao*, Hongxia Liu and Yuyang Jiang, 8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90α downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells, Scientific Reports, 2018, 8, 309.
[2] Anqi Li, Chunyan Tan*, Tianying Yuan, Jiamei Liang, Dan Gao*, Ying Tan, Yuyang Jiang*, Efficient photocatalytic oxidation sensitized by conjugated polymers in a batch reaction and microreactors under visible light, J. Mater. Chem. A, 2018, 6, 15927-15932.
[3] Yongli Chen, Dan Gao^*, Yanwei Wang, Shuo Lin, Yuyang Jiang, A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems, Analytica Chimica Acta, 2018, 1036, 97-106.
[4] Wenrui Liu, Feng Jin, Dan Gao*, Lu Song, Chao Ding and Hongxia Liu*, Metabolomics analysis reveals aminoquinazolin derivative 9d-induced oxidative stress and cell cycle arrest in A549 cells, RSC Advances, 2017, 7, 13149–13158.
[5] Xiaojian Shao, Dan Gao*, Yongli Chen, Feng Jin, Guangnan Hu, Yuyang Jiang, Hongxia Liu*, Development of a blood-brain barrier model in a membrane-based microchip for characterization of drug permeability and cytotoxicity for drug screening, Analytical Chimica Acta, 2016, 934, 186-193.
[6]Yini Wang, Dan Gao, Bizhu Chu, Chunmei Gao, Deliang Cao, Hongxia Liu*, Yuyang Jiang, Exposure of CCRF-CEM cells to acridone derivative 8a triggers tumor death via multiple mechanisms, Proteomics 2016, 16, 1177–1190.
[7]Weiyi Xie, Dan Gao*, Feng Jin, Yuyang Jiang, and Hongxia Liu*. Study of Phospholipids in Single Cells Using an Integrated Microfluidic Device Combined with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. Analytical Chemistry, 2015, 87, 7052？7059.
[8]Qin Wu1, Dan Gao1, Juntong Wei, Feng Jin, Weiyi Xie, Yuyang Jiang*, Hongxia Liu*. Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening. Chemical Communications, 2014, 50, 2762-2764. (1The two authors contributed equally to this work)
[9]Dan Gao, Hongxia Liu, Yuyang Jiang and Jin-Ming Lin*. Recent advances in microfluidics combined with mass spectrometry: technologies and applications. Lab on a Chip, 2013, 13, 3309-3322.
[10]Dan Gao, Hongxia Liu, Jin-Ming Lin*, Yini Wang and Yuyang Jiang*. Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device, Lab on a Chip, 2013, 13, 978-985.
[11] Dan Gao, Hongxia Liu, Yuyang Jiang and Jin-Ming Lin*. Recent development of microfluidic devices in vitro cell culture for cell biology research, Trends in Analytical Chemistry, 2012, 35, 150–164.
[12]Dan Gao, Haifang Li, Niejun Wang, and Jin-Ming Lin*. Evaluation of the Absorption of Methotrexate on Cells and Its Cytotoxicity Assay by Using an Integrated Microfluidic Device Coupled to a Mass Spectrometer, Analytical Chemistry, 2012, 84, 9230-9237.
[13]Dan Gao, Huibin Wei, Guang-Sheng Guo, and Jin-Ming Lin*. Microfluidic Cell Culture and Metabolism Detection with Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometer, Analytical Chemistry, 2010, 82, 5679-5685.
[14]Dan Gao, Jiangjiang Liu, Hui-Bin Wei, Hai-Fang Li, Guang-Sheng Guo, Jin-Ming Lin*. A Microfluidic Approach for Anticancer Drug Analysis Based on Hydrogel Encapsulated Tumor Cells, Analytica Chimica Acta, 2010, 665, 7–14.
[15]Dan Gao, Hai-Fang Li, Guang-Sheng Guo, and Jin-Ming Lin*. Magnetic Bead Based Immunoassay for Enumeration of CD4+ T Lymphocytes on a Microfluidic Device, Talanta, 2010, 82, 528-533.