林进顺讲师 电话：**　　
邮箱：lin.jinshun@sz.tsinghua.edu.cn办公地址：清华大学深圳研究生院J楼402B
所属学科：化学生物学
主要从事 ：
1、抗肿瘤小分子化合物的设计、合成与生物活性研究；2：手性药物导向的不对称催化有机合成方法学研究。
2、不对称催化的有机合成方法学研究



【个人简历】
2018年至今清华大学深圳研究生院 讲师
2015年-2018年 中国科学院大连化学物理研究所与南方科技大学联合培养 博士后
2013年-2015年 南方科技大学 助理研究员（Research Fellow）
2008年-2013年 清华大学 博士
2005年-2008年 沈阳药科大学 硕士
2001年-2005年 齐齐哈尔大学 学士
【教学】
《合成有机化学》、《有机波谱学》和《药物化学专题实验》
【研究领域】
主要研究方向：(1) 具有生物活性的天然产物的全合成和计算机辅助抗肿瘤活性小分子化合物的设计、合成与抗肿瘤活性研究、 (2)手性药物导向的过渡金属/小分子协同催化的不对称合成。目前已经在化学类国际一流刊物(Angew. Chem. Int. Ed. 2019, DOI:10.1002/anie.. J. Am. Chem. Soc. 2019, 141, 1074. Chem 2017. 3, 979. Nat. Commun 2017, 8, 14841. J. Am. Chem. Soc. 2016, 138, 9357. Angew. Chem. Int. Ed. 2015, 54, 7847. ACS catal. 2015, 5, 2826.)等发表文章20篇，总被引用500多次。
正在主持国家自然科学基金青年基金1项(**)和省部共建肿瘤化学基因组学国家重点实验室自主研究课题项目1项；正在主要参与了国家自然科学基金优秀青年科学基金项目1项、国家自然科学基金青年基金1项、国家自然科学基金面上项目1项，深圳市科技计划1项。
【研究成果】

[1] Jin-Shun Lin, Tao-Tao Li, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and XinYuan Liu*.Chiral Br？nsted Acid-Catalyzed Dynamic KineticAsymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes.Angew. Chem. Int. Ed.2019, DOI:10.1002/anie..
[2] Jin-Shun Lin, Tao-Tao Li, Ji-Ren Liu, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng,Yu-Long Guo,Xin Hong*and Xin-Yuan Liu*.Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes. J. Am. Chem. Soc. 2019, 141, 1074.Highlighted in Synfacts2019, 15, 0255.
[3] Fu-Li Wang#, Xiao-Yang Dong,#Jin-Shun Lin,#Yang Zeng, Guang-YuanJiao,Qiang-ShuaiGu, Xiang-QiGuo, Can-LiangMa, Xin-Yuan Liu*.Catalytic Asymmetric Radical Diamination of Alkenes. Chem 2017. 3, 979.(#Co-first author)Highlighted in Chem2017, 3, 919.
[4] Jin-Shun Lin, Fu-Li Wang, Xiao-Yang Dong,Wei-Wei He, Yue Yuan, Su Chen, Xin-Yuan Liu*. “Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes with Fluoroalkylsulfonyl Chlorides: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines”. Nat. Commun.2017,8, 14841.
[5] Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu*. “A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes”.J. Am. Chem. Soc.2016, 138, 9357.Highlighted in Synfacts, 2016, 1020.Highlighted in Chin. J. Org. Chem.2016, 36, 2247.
[6] Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu*.“Br？nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter”. Angew. Chem. Int. Ed.2015, 54, 7847.Highlighted in Chin. J. Org. Chem., 2015, 35, 1802.
[7] Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu*.“Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles”.Chem. Eur. J.2014, 20, 1332.
[8] Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu*.“Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles”. J. Org. Chem. 2014, 79, 7084.
[9] Peng Yu,Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu*.“Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene”.Angew. Chem. Int. Ed.2014, 53, 11890.Highlighted in Synfacts, 2014, 10, 1281.
[10] Lin Huang, Jin-Shun Lin, Bin Tan,* and Xin-Yuan Liu*.“Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam”. ACS Catal.2015, 5, 2826.
[11] Xue-Fei Li, Jin-Shun Lin,Jian Wang, Zhong-Liang Li, Qiang-Shuai Gu, Xin-Yuan Liu*.“Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Radical-Initiated Aminoarylation of Alkenes”. Acta Chim. Sinica, 2018, 76, 878.
[12] Xue-Fei Li, Jin-Shun Lin, Xin-Yuan Liu*. “Catalytic Radical Intramolecular Aminoperfluoroalkylation and Aminodifluoromethylation of Unactivated Alkenes with Fluoroalkylsulfonyl Chlorides”. Synthesis. 2017, 49, 4213.
[13] Taotao Li, Peng Yu, Yi-Meng Du, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu*.“Dual-Catalyzed Enantioselective Remote C？H Functionalization Triggered by Radical Trifluoromethylation of Alkenes: Highly Selective Formation of C？CF3and C？C Bonds”.J. Fluorine Chem. 2017, 203, 210.
[14] Ping Song, Peng Yu, Jin-Shun Lin,Yang, N.-Y.; Liu, X.-Y. “Transition-Metal-Free β？C？H Bond Carbonylation of Enamides orAmides with a Trifluoromethyl Group as CO Surrogate for theSynthesis of 1,3-Oxazin-6-ones”. Org.Lett.2017, 19, 1330.
[15] Lin Huang,Liu Ye,Xiao-Hua Li,Zhong-Liang Li, Jin-Shun Lin, and Xin-Yuan Liu*.“Stereoselective Radical Cyclization Cascades Triggered by Addition of Diverse Radicals to Alkynes to Construct 6(5)‐6‐5 Fused Rings”.Org. Lett.2016, 18, 5284.
[16] Taotao Li, Peng Yu, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu,*Copper-Catalyzed Redox-Triggered Remote C–H Functionalization: Highly Selective Formation of C–CF3and C–O Bonds”. Chin. J. Chem.2016, 34, 490.
[17] Jin-Shun Lin,XiuliJin, YiwenBu, DeliangCao,NannanZhang, ShangfuLi,QinshengSun, ChunyanTan, ChunmeiGao,YuyangJiang*.“Efficient Synthesis of RITA and its Analogues: Derivation of Analogues with Improved Antiproliferative Activity viaModulation of p53/miR-34a Pathway”.Org.Biomol. Chem.2012.10, 9734.
[18] Jin-Shun Lin,FengLiu,YuyangJiang*.“Antisense Technologies Targeting Fatty Acid Synthetic Enzymes”.Recent PatAnti-Canc, 2012;7, 198.
[19] FengZhu,Chu Qin,Lin Tao,Xin Liu,Zhe Shi,Xiaohua Ma,Jia Jiang,YingTan, ChengCui,Jin-Shun Lin,Chunyan Tan,YuyangJiang*,Yuzong Chen*.“Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting”.PNAS.2011; 108, 12943.
[20] Jin-Shun Lin,WeigeZhang*, NanJiang, et al. “Total Synthesis of Bulbophylol-B”.J.Nat.Prod.2008;71, 1938.
【奖励荣誉】

The winner of SUSTech Presidential Postdoctoral Fellowship (Top 10%), SUSTech, China. 2017.