文献详情
ANTAGONISM AND NEGATIVE SIDE-EFFECTS IN COMBINATION THERAPY FOR CANCER
文献类型：期刊
通讯作者：Friedman, A (reprint author), Ohio State Univ, Math Biosci Inst, Columbus, OH 43210 USA.; Friedman, A (reprint author), Ohio State Univ, Dept Math, 231 W 18th Ave, Columbus, OH 43210 USA.
期刊名称：DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B影响因子和分区
年：2019
卷：24
期：5
页码：2237-2250
ISSN：1531-3492
关键词：Combination therapy; chemotherapy; anti-PD-1; antagonism; side-effects
所属部门：数学科学研究院
摘要：Most clinical trials with combination therapy fail. One of the reasons is that not enough forethought is given to the interaction between the different agents, as well as the potential negative side-effects that may arise in the combined therapy. In the present paper we consider a generic cancer model with combination therapy consisting of chemotherapy agent X and checkpoint inhibitor A. We use a mathematical model to investigate the results of injecting different amounts gamma X of X and gamma ...More
Most clinical trials with combination therapy fail. One of the reasons is that not enough forethought is given to the interaction between the different agents, as well as the potential negative side-effects that may arise in the combined therapy. In the present paper we consider a generic cancer model with combination therapy consisting of chemotherapy agent X and checkpoint inhibitor A. We use a mathematical model to investigate the results of injecting different amounts gamma X of X and gamma A of A. We show that there are some regions in the (gamma A, gamma X)-plane where as increase in gamma X or gamma A actually decreases the tumor volume; such 'regions of antagonism' should be avoided in clinical trials. We also show how to achieve the same level of tumor volume reduction with least negative-side effects, where the side-effects are represented by the level of inflammation of the tumor microenvironment. ...Hide

DOI：10.3934/dcdsb.2019093
百度学术：ANTAGONISM AND NEGATIVE SIDE-EFFECTS IN COMBINATION THERAPY FOR CANCER
语言：外文
人气指数：2
浏览次数：2
基金：Mathematical Biosciences Institute; National Science FoundationNational Science Foundation (NSF) [DMS 0931642]
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