文献详情
How to schedule VEGF and PD-1 inhibitors in combination cancer therapy?
文献类型：期刊
通讯作者：Friedman, A (reprint author), Ohio State Univ, Math Biosci Inst, Columbus, OH 43210 USA.; Friedman, A (reprint author), Ohio State Univ, Dept Math, 231 W 18th Ave, Columbus, OH 43210 USA.
期刊名称：BMC SYSTEMS BIOLOGY影响因子和分区
年：2019
卷：13
ISSN：1752-0509
关键词：Anti-PD-1; Anti-VEGF; Combination therapy; Scheduling; PDE model
所属部门：数学科学研究院
摘要：BackgroundOne of the questions in the design of cancer clinical trials with combination of two drugs is in which order to administer the drugs. This is an important question, especially in the case where one agent may interfere with the effectiveness of the other agent.ResultsIn the present paper we develop a mathematical model to address this scheduling question in a specific case where one of the drugs is anti-VEGF, which is known to affect the perfusion of other drugs. As a second drug we tak ...More
BackgroundOne of the questions in the design of cancer clinical trials with combination of two drugs is in which order to administer the drugs. This is an important question, especially in the case where one agent may interfere with the effectiveness of the other agent.ResultsIn the present paper we develop a mathematical model to address this scheduling question in a specific case where one of the drugs is anti-VEGF, which is known to affect the perfusion of other drugs. As a second drug we take anti-PD-1. Both drugs are known to increase the activation of anticancer T cells. Our simulations show that in the case where anti-VEGF reduces the perfusion, a non-overlapping schedule is significantly more effective than a simultaneous injection of the two drugs, and it is somewhat more beneficial to inject anti-PD-1 first.ConclusionThe method and results of the paper can be extended to other combinations, and they could play an important role in the design of clinical trials with combination therapy, where scheduling strategies may significantly affect the outcome. ...Hide

DOI：10.1186/s12918-019-0706-y
百度学术：How to schedule VEGF and PD-1 inhibitors in combination cancer therapy?
语言：外文
基金：Mathematical Biosciences Institute; National Science FoundationNational Science Foundation (NSF) [DMS 0931642]; Renmin University of China; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [11501568]; International Postdoctoral Exchange Fellowship Program 2016 by the Office of China Postdoctoral Council
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