文献详情
Mathematical modeling in scheduling cancer treatment with combination of VEGF inhibitor and chemotherapy drugs
文献类型：期刊
通讯作者：Lai, XL (reprint author), Renmin Univ China, Inst Math Sci, Beijing, Peoples R China.
期刊名称：JOURNAL OF THEORETICAL BIOLOGY影响因子和分区
年：2019
卷：462
页码：490-498
ISSN：0022-5193
关键词：Combination therapy; Anti-VEGF; Chemotherapy; Scheduling; Mathematical model
所属部门：数学科学研究院
摘要：The present paper considers a treatment of cancer with a combination of anti-VEGF (bevacizumab) and a chemotherapy drug (docetaxel). Since anti-VEGF reduces the perfusion of chemotherapy drugs, the question arises whether it is more effective to administer the two drugs at the same time, or non-overlapping, in order to reduce tumor volume more effectively. To address this question we develop a mathematical model and use it to simulate different schedules. We find that the treatment of cancer wou ...More
The present paper considers a treatment of cancer with a combination of anti-VEGF (bevacizumab) and a chemotherapy drug (docetaxel). Since anti-VEGF reduces the perfusion of chemotherapy drugs, the question arises whether it is more effective to administer the two drugs at the same time, or non-overlapping, in order to reduce tumor volume more effectively. To address this question we develop a mathematical model and use it to simulate different schedules. We find that the treatment of cancer would be far more effective if the two drugs are given non-overlappingly, with the chemotherapy drug at day 0 and anti-VEGF at day 7 in cycles of 21 days. (C) 2018 Elsevier Ltd. All rights reserved. ...Hide

DOI：10.1016/j.jtbi.2018.11.018
百度学术：Mathematical modeling in scheduling cancer treatment with combination of VEGF inhibitor and chemotherapy drugs
语言：外文
被引频次：4
人气指数：2
浏览次数：2
基金：Mathematical Biosciences Institute [DMS 0931642]; National Science FoundationNational Science Foundation (NSF) [DMS 0931642]; Renmin University of China [11501568]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [11501568]; International Postdoctoral Exchange Fellowship Program 2016 by the Office of China Postdoctoral Council
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ROLE OF WHITE-TAILED DEER IN GEOGRAPHIC SPREAD OF THE BLACK-LEGGED TICK IXODES SCAPULARIS : ANALYSIS OF A SPATIALLY NONLOCAL MODEL.Gourley, Stephen A., Lai, Xiulan, Shi, Junping, et al. .MATHEMATICAL BIOSCIENCES AND ENGINEERING. 2018, 15(4), 1033-1054.
A stochastic model that explains axonal organelle pileups induced by a reduction of molecular motors.Lai, Xiulan, Brown, Anthony, Xue, Chuan,.JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2018, 15(148).
ANTAGONISM AND NEGATIVE SIDE-EFFECTS IN COMBINATION THERAPY FOR CANCER.Friedman, Avner, Lai, Xiulan,.DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B. 2019, 24(5), 2237-2250.
How to schedule VEGF and PD-1 inhibitors in combination cancer therapy?.Lai, Xiulan, Friedman, Avner,.BMC SYSTEMS BIOLOGY. 2019, 13.
Global stability analysis of a viral infection model in a critical case.Wang, Wei, Lai, Xiulan,.MATHEMATICAL BIOSCIENCES AND ENGINEERING. 2020, 17(2), 1442-1449.