文献详情
Novel trends for producing plant triterpenoids in yeast
文献类型：期刊
期刊名称：Critical reviews in biotechnology影响因子和分区
年：2019
卷：39
期：5
页码：618-632
ISSN：1549-7801
关键词：Plant triterpenoid,UDP-glycosyltransferase,cytochrome P450,oxidosqualene cyclase,yeast
摘要：Triterpenoids possess versatile biological activities including antiviral, anticancer, and hepatoprotective activities. They are widely used in medicine and other health-related fields. However, current production of such compounds relies on plant culture and extraction, which brings about concerns for environmental, ecological, and infield problems. With increasing awareness of environmental sustainability, various microbes have been engineered to produce natural products, in which yeast turned ...More
Triterpenoids possess versatile biological activities including antiviral, anticancer, and hepatoprotective activities. They are widely used in medicine and other health-related fields. However, current production of such compounds relies on plant culture and extraction, which brings about concerns for environmental, ecological, and infield problems. With increasing awareness of environmental sustainability, various microbes have been engineered to produce natural products, in which yeast turned out to be feasible for the heterologous biosynthesis of triterpenoids on account of its inherent advantages such as the robustness, safety, and sufficient precursor supplementation. This review has focused on recent progress regarding the biosynthesis of triterpenoids in yeast. The key enzymes to reconstruct the triterpenoid pathways in yeast, include: oxidosqualene cyclases, cytochrome P450s and UDP-glycosyltransferases are systematically presented. We then discuss recent metabolic engineering strategies and future prospects of protein engineering, pathway compartmentalization, product transportation, and other aspects for triterpenoid production in yeast. ...Hide

DOI：10.1080/07388551.2019.1608503
百度学术：Novel trends for producing plant triterpenoids in yeast
语言：外文
作者其他论文



Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial.He Jing, Zhang Ruijun, Shao Miao, et al. .Annals of the rheumatic diseases. 2020, 79(1), 141-149.
Too-Much-Of-A-Good-Thing Effect of External Resource Investment-A Study on the Moderating Effect of Psychological Capital on the Contribution of Social Support to Work Engagement.Xi Yiheng, Xu Yangyang, Wang Ying,.International journal of environmental research and public health. 2020, 17(2).
Research on Availability of Corporate Governance Model and Corporate Governance Structure.Li Chun.Exchange Conference on International Marketing Science and Information Technology.2011,139-143.