文献详情
Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites
文献类型：期刊
期刊名称：The EMBO journal
年：2019
卷：38
期：8
ISSN：1460-2075
关键词：SREBP,COPII vesicles,Cideb,fatty liver,lipid metabolism
所属部门：数学科学研究院
摘要：SREBPs are master regulators of lipid homeostasis and undergo sterol-regulated export from ER to Golgi apparatus for processing and activation via COPII-coated vesicles. While COPII recognizes SREBP through its escort protein SCAP, factor(s) specifically promoting SREBP/SCAP loading to the COPII machinery remains unknown. Here, we show that the ER/lipid droplet-associated protein Cideb selectively promotes the loading of SREBP/SCAP into COPII vesicles. Sterol deprivation releases SCAP from Insig ...More
SREBPs are master regulators of lipid homeostasis and undergo sterol-regulated export from ER to Golgi apparatus for processing and activation via COPII-coated vesicles. While COPII recognizes SREBP through its escort protein SCAP, factor(s) specifically promoting SREBP/SCAP loading to the COPII machinery remains unknown. Here, we show that the ER/lipid droplet-associated protein Cideb selectively promotes the loading of SREBP/SCAP into COPII vesicles. Sterol deprivation releases SCAP from Insig and enhances ER export of SREBP/SCAP by inducing SCAP-Cideb interaction, thereby modulating sterol sensitivity. Moreover, Cideb binds to the guanine nucleotide exchange factor Sec12 to enrich SCAP/SREBP at ER exit sites, where assembling of COPII complex initiates. Loss of Cideb inhibits the cargo loading of SREBP/SCAP, reduces SREBP activation, and alleviates diet-induced hepatic steatosis. Our data point to a linchpin role of Cideb in regulated ER export of SREBP and lipid homeostasis.? 2019 The Authors. Published under the terms of the CC BY NC ND 4.0 license. ...Hide

DOI：10.15252/embj.2018100156
百度学术：Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites
语言：外文
人气指数：2
浏览次数：2
作者其他论文



Maximizing multiple influences and fair seed allocation on multilayer social networks.Chen Yu, Wang Wei, Feng Jinping, et al. .PloS one. 2020, 15(3), e0229201.
Attention mechanism enhanced LSTM with residual architecture and its application for protein-protein interaction residue pairs prediction.Liu Jiale, Gong Xinqi,.BMC bioinformatics. 2019, 20(1), 609.
A Novel Index of Contact Frequency from Noise Protein-Protein Interaction Data Help for Accurate Interface Residue Pair Prediction.Lyu Yanfen, Huang He, Gong Xinqi,.Interdisciplinary sciences, computational life sciences. 2020.
Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis.Gao, Lu;Hong, Xiafei;Guo, Xiaopeng,等.ONCOTARGET.2016,7(28),43557-43569.
CLE42 binding induces PXL2 interaction with SERK2.Mou, Shulin;Zhang, Xiaoxiao;Han, Zhifu,等.PROTEIN & CELL.2017,8(8),612-617.