孙玲伟3,
孙诗谣1,2,
戴建军3,
张德福3,
杨俊花1,,,
赵志辉1,2,,
1. 上海市农业科学院农产品质量标准与检测技术研究所, 上海 201403;
2. 上海海洋大学食品学院, 上海 201306;
3. 上海市农业科学院畜牧兽医研究所, 上海 201106
作者简介: 凌阿茹(1995-),女,硕士,研究方向为真菌毒素毒理学,E-mail:larjy123@163.com.
通讯作者: 杨俊花,yangjunhua303@126.com ; 赵志辉,18918162068@163.com
基金项目: 国家自然科学基金资助项目（31901804）中图分类号: X171.5
Research Progress on Toxic Effect of Individual or Combined Mycotoxins Exposure to Leydig Cells
Ling Aru1,2,Sun Lingwei3,
Sun Shiyao1,2,
Dai Jianjun3,
Zhang Defu3,
Yang Junhua1,,,
Zhao Zhihui1,2,,
1. Institute for Agri-Food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China;
2. College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China;
3. Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China
Corresponding authors: Yang Junhua,yangjunhua303@126.com ; Zhao Zhihui,18918162068@163.com
CLC number: X171.5
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摘要:霉菌毒素是由霉菌产生的一系列有毒次级代谢产物，广泛存在于被污染的饲料或饲料原料中。这些代谢物在饲料储藏、运输或加工过程中均可产生，具有分布广、毒性强等特点，是食品和饲料中最主要的污染物，可对雄性生殖系统产生危害。霉菌毒素可导致睾酮合成和分泌能力下降、精子生成缺陷和质量下降，甚至造成不育等。睾丸间质细胞主要负责雄性激素的合成和分泌，对维持雄性机体生殖机能具有重要意义。然而这类细胞对玉米赤霉烯酮、T-2毒素等霉菌毒素比较敏感。研究表明，自然条件下多种毒素共同污染非常普遍，且多种毒素对动物健康和生殖系统的联合毒性比单一毒素的危害更严重。霉菌毒素已被证实可诱导的睾丸细胞DNA损伤、线粒体损伤以及细胞凋亡或自噬等。鉴于此，笔者综述了霉菌毒素对睾丸间质细胞毒性作用的研究进展，旨在为开展单一或多种霉菌毒素暴露对睾丸间质细胞的毒性作用机制研究提供思路和理论支持。
关键词: 霉菌毒素/
玉米赤霉烯酮/
T-2毒素/
睾丸间质细胞/
毒性作用机制
Abstract:Mycotoxins are a group of secondary toxic metabolites produced by a variety of fungi, which could be detected in feedstuffs and feed ingredients at any stage of storage, transport, or processing. Due to high toxicity and widespread distribution, mycotoxins are considered among the most critical contaminants in foods and feeds, which generally results in a significant damage to male reproductive system in animals. The common clinical symptoms and signs are reduction of testosterone synthesis and secretion, defect in sperm production and low quality, and possibly even infertility. Leydig cells (LCs) responsible for the biosynthesis and secretion of androgens, which are critical for the development of the reproductive function in the male. As one of the major testicular cells, LCs are sensitive to certain mycotoxins, such as zearalenone and T-2 toxin. Co-contamination by multiple mycotoxins occurs naturally, and exerts greater negative impacts on health and productivity of animals than contamination by individual mycotoxin. Mycotoxin-induced DNA and mitochondrial damages, even cellular apoptosis or autophagy have been reported. In lights of above-mentioned, this study is aimed to provide theoretical supports for exploring the toxic mechanism of individual or multiple mycotoxins exposure to LCs by summarizing the recent developments of toxic effects of mycotoxins on LCs.
Key words:mycotoxins/
zearalenone/
T-2 toxin/
Leydig cells/
mechanism of toxicity.
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