孙小艳^1,2,
卢坤³,
李奥¹,
高士祥³,
毛亮³,
叶新华¹
1. 南京医科大学第一附属医院, 南京 210029;
2. 南京市栖霞区医院, 南京 210033;
3. 南京大学环境学院, 污染控制与资源化研究国家重点实验室, 南京 210046

作者简介: 孙小艳(1983-),女,硕士研究生、主治医师,研究方向为超声诊断在纳米材料负载药物治疗乳腺癌研究中的应用,E-mail:mlnju@163.com.

基金项目: 2014年国家自然科学基金青年项目(相变型多功能分子探针显像及治疗肝癌射频消融后残余灶，81401427)


中图分类号: X171.5

Application of Graphene-based Materials as Drug Carrier Materials and Their Potential Risks: A Review

Sun Xiaoyan^1,2,
Lu Kun³,
Li Ao¹,
Gao Shixiang³,
Mao Liang³,
Ye Xinhua¹
1. The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China;
2. Nanjing Qixia District Hospital, Nanjing 210033, China;
3. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210046, China

CLC number: X171.5

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摘要:石墨烯作为一种新兴的二维碳纳米材料,近年来受到了医学领域科学家的高度关注。由于石墨烯类纳米材料具有较大的比表面积,易于表面修饰等优点,目前在药物载体方面的研究发展迅速。随着纳米技术的发展,除了氧化石墨烯外,进一步将还原氧化石墨烯、石墨烯量子点、石墨烯纳米带等石墨烯类纳米材料作为药物载体应用到医学领域。本文综述了石墨烯类纳米材料作为药物载体在医学领域的研究进展,并从石墨烯类纳米材料的相关毒性研究角度,提醒了人们负载药物前后石墨烯类纳米材料的迁移规律对其潜在风险研究的重要性。
关键词: 氧化石墨烯/
石墨烯量子点/
石墨烯纳米带/
药物载体/
迁移途径/
潜在风险

Abstract:In the realm of drug delivery, graphene family materials have gained tremendous attention as promising nanocarriers, owing to their distinct characteristics, such as high surface area, enhanced cellular uptake and the possibility to be easily conjugated with many therapeutics, including both small molecules and biologics. Specially, reduced graphene oxide (rGO), graphene quantum dots (GQDs) and graphene nanoribbons (GNRs) are being widely studied as drug carriers. This paper reviews the latest development of graphene-based materials as drug carriers in biomedical research fields and discusses emphatically their translocation pathways and in vivo toxicities, which remind researcher the potential risks of the graphene-based materials as the drugs carrier.
Key words:graphene oxide/
graphene quantum dots/
graphene nanoribbons/
drug carriers/
translocation behaviors/
potential risks.