赵砚彬,
胡建英^,
北京大学 城市与环境学院, 北京 100871

作者简介: 赵砚彬(1984-),男,博士,研究方向为环境毒理学,Email:zhaoyb@pku.edu.cn.

通讯作者: 胡建英,hujy@urban.pku.edu.cn

基金项目: 国家自然科学基金项目(No.41330637)


中图分类号: X171.5

Ecotoxicology of Environmental Progestogens and Glucocorticoids: A Short Review

Zhao Yanbin,
Hu Jianying^,
College of Urban and Environmental Sciences, Peking University, Beijing 100871, China

Corresponding author: Hu Jianying,hujy@urban.pku.edu.cn

CLC number: X171.5

-->

摘要
HTML全文
图(0)表(0)
参考文献(0)
相关文章
施引文献
资源附件(0)
访问统计

摘要:孕激素和糖皮质激素的环境行为和生态毒理效应是即环境雌激素和雄激素之后近年来国内外环境激素研究的又一热点课题。由于广泛应用于临床医疗等，这两类物质通过污水处理厂不完全处理和人类农业或畜牧业活动的直接排放从而进入水体环境，进而对生态系统和人类健康产生潜在危害。环境监测数据显示，在地表水中，多种物质存在ng·L^-1浓度水平；在污水处理厂进出水中，浓度水平更高，甚至达到数百ng·L^-1。孕激素和糖皮质激素类物质主要通过激素受体途径发挥毒性效应，如孕激素受体(PR),糖皮质激素受体(GR)和盐皮质激素受体(MR)。对水生脊椎动物的内分泌系统干扰作用是目前研究的焦点。这两类物质能够影响脑垂体性腺轴转录水平和相应激素合成，影响性腺发育以及导致繁殖能力损伤。这一毒性效应甚至发生在环境浓度水平之下。除此之外，随着组学技术的广泛应用，更多的潜在毒性终点不断被发掘，如对昼夜节律系统和免疫应答的干扰作用。这些研究引导着对环境孕激素和糖皮质激素生态毒理学效应更加深入的理解。
关键词: 孕激素/
糖皮质激素/
环境行为/
生态毒理效应/
内分泌干扰/
昼夜节律/
免疫反应

Abstract:Environmental behavior and ecotoxicological effects of progestogens and glucocorticoids are of increasing concern in recent years. They are used in a range of medical conditions, and reach aquatic ecosystem due to the incomplete removal by wastewater treatment plant (WWTP) and agricultural run-off, then cause the potential hazard to the ecological system and human health. A few ng·L^-1 of progestogens and glucocorticoids were widely detected in surface water while in the influents and effluents of WWTP the concentrations were up to several hundred ng·L^-1. They exert toxic effects primarily via binding to nuclear hormone receptors, for instance, the progesterone receptor (PR), glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). Endocrine disrupts of aquatic vertebrates are of mainly concern. They alter the transcriptional levels of genes involved in hypothalamic-pituitary-gonadal axis and blood hormone concentrations, impact gonadal histology and disrupt fish reproduction, even at environmental relevant levels. Besides, novel targets are uncovered recently by use of "Omics" technology, such as the alterations on circadian rhythm signals and immune responses. These provide us novel insights of potential ecotoxicological effects of progestogens and glucocorticoids.
Key words:progestogens/
glucocorticoids/
environmental behavior/
ecotoxicology/
endocrine disruption/
circadian rhythm/
immune response.