高晓洁^1,2,3,
孔璐^1,2,3,,,
薛玉英^1,2,3,,
1. 东南大学公共卫生学院&苏州纳米科技协同创新中心, 南京 210009;
2. 环境医学工程教育部重点实验室, 南京 210009;
3. 江苏省生物材料与器件重点实验室, 南京 210009

作者简介: 高晓洁(1992-),女,硕士研究生,研究方向为纳米毒理学,E-mail:2534888732@qq.com.

通讯作者: 孔璐,konglu_yaoyu@126.com ; 薛玉英,yyxue@seu.edu.cn

基金项目: 国家重大科学研究计划项目(No.2011CB933404)；国家自然科学基金项目(81502783，81573186,81302461,81473003,,31671034，81673218)


中图分类号: X171.5

Biological Distribution and Its Influence Factor of Silver Nanoparticles: A Review

Gao Xiaojie^1,2,3,
Kong Lu^1,2,3,,,
Xue Yuying^1,2,3,,
1. School of Public Health of Southeast University & Collaborative Innovation Center of Suzhou Nanoscience and Technology, Nanjing 210009, China;
2. Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, Nanjing 210009, China;
3. Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210009, China

Corresponding authors: Kong Lu,konglu_yaoyu@126.com ; Xue Yuying,yyxue@seu.edu.cn

CLC number: X171.5

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摘要:纳米银(Ag NPs)以其独特的抗菌性能在生物医药和消费品中得到大量应用。然而，随着人类接触Ag NPs的机会增多，Ag NPs暴露的潜在危害也不容忽视。体内研究表明，Ag NPs可以通过经口、呼吸、腹腔、静脉等途径进入机体，进而通过血液或淋巴液的流动分散到全身不同组织器官。而不同的暴露方式、暴露剂量、Ag NPs粒径、表面包被和电荷以及暴露器官本身的特点可能对Ag NPs在体内的分布与蓄积产生影响。因此，本文系统地总结了Ag NPs进入生物体的途径及其在生物体内的组织分布，讨论了影响Ag NPs体内生物分布和蓄积的因素。
关键词: 纳米银/
暴露/
分布/
蓄积

Abstract:Silver nanoparticles (Ag NPs) have been applied a lot in biomedicine and other products because of its antibacterial property. However, as we use Ag NPs more frequently, the potential disadvantages of the exposure of Ag NPs can't be ignored. In vivo experiments suggest that Ag NPs can enter into the body through mouth, respiratory tract, abdomen, vein and so on, and then distributed to various tissues and organs through blood or lymph flow. The distribution and accumulation of Ag NPs can be effected by exposure ways, exposure dose, particle size, coat, charge and characteristics of the organ itself. This paper systematically summarizes the ways that Ag NPs enter into the living organism and its distribution among tissues, and discusses the factors influencing the distribution and accumulaiton of Ag NPs.
Key words:Ag nanoparticles/
Ag NPs/
exposure/
distribution.