远期恐惧记忆再巩固更新机制的线索选择性特点

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胡静初¹^,², 张蔚欣¹^,³, 陈小婷¹, 王文清¹, 王子洁¹, 庄楚群¹, 冯彪¹, 郑希付¹(

)

1华南师范大学心理学院
2华南师范大学生命科学学院, 广州 510631
3中山纪念中学, 广东中山 528400

收稿日期:2017-12-05出版日期:2019-03-25发布日期:2019-01-22
通讯作者:郑希付E-mail:zhengxf@scnu.edu.cn

基金资助:* 国家自然科学基金(31771218);广东省自然科学基金博士科研启动基金资助(2018A030310661);中国博士后科学基金第64批面上项目资助(2018M640791)

Cue specificity of reconsolidation update mechanism in remote fear memories

HU Jingchu¹^,², ZHANG Weixin¹^,³, CHEN Xiaoting¹, WANG Wenqing¹, WANG Zijie¹, ZHUANG Chuqun¹, FENG Biao¹, ZHENG Xifu¹(

)

1 School of Psychology, South China Normal University, Guangzhou, 510631, China
2 School of Life Sciences, South China Normal University, Guangzhou, 510631, China
3 Sun Yat-Sen Memorial Secondary School, Zhongshan, 528400, China

Received:2017-12-05Online:2019-03-25Published:2019-01-22
Contact:ZHENG Xifu E-mail:zhengxf@scnu.edu.cn

摘要/Abstract

摘要： 已有动物和人类研究均表明, 通过记忆的再巩固更新机制能有效削弱新形成的条件性恐惧记忆(1天), 并且存在线索选择性特点。然而创伤后应激障碍(PTSD)往往在形成相当一段时间后才能得到治疗, 且现实生活中人们通常一次习得对多个线索的恐惧。因此找到针对多线索创伤记忆的有效治疗方法显得尤为重要。目前未有人研究远期恐惧记忆的再巩固更新机制是否存在线索选择性特点。为探究远期恐惧记忆(>7天)的再巩固更新机制是否同样存在线索选择性特点, 本研究采用被试内实验设计, 以皮肤电作为恐惧反应指标, 多个线索作为条件刺激进行恐惧习得, 习得14天后给被试单独呈现一个线索进行恐惧记忆提取, 10分钟后进行消退训练, 24小时后对不同线索进行自发恢复测试。结果显示：未提取线索的自发恢复程度显著高于提取线索。说明远期记忆(14天)的再巩固更新机制同样存在线索选择性特点, 并确认了提取消退作为一种行为手段对远期恐惧记忆再巩固进行干预的有效性, 对临床干预具有一定指导意义。

图/表 6

图1远期恐惧记忆再巩固实验的刺激材料

图2实验流程

图3实验刺激呈现示意图

图4各阶段不同刺激类型的皮电反应值变化

图5各阶段不同刺激类型的皮电反应均值注：习得阶段(Acquisition)为习得后半段均值(后5个试次的均值); 消退(Extinction)为消退最后一个试次均值, 自发恢复(Recovery)为自发恢复第一个试次均值。

图6CSa+/CSb+与CS-在自发恢复测试阶段第一个试次和消退阶段最后一个试次的皮电差值注：* p < 0.05 CSb+与CS-在自发恢复测试阶段第一个试次的皮电差值与在消退阶段最后一个试次的皮电差值存在显著差异。

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