健康与遗传心理学研究室,副研究员
电话:86-10-64877528
传真:86-10-64872070
通讯地址:北京市朝阳区林萃路16号院中科院心理所
邮政编码:100101
电子邮件:zhengxg@psych.ac.cn
课题组网站:
43岁。中国科学院心理研究所心理健康院重点实验室/实验临床心理学研究室副研究员,专业方向:基础心理学(生物心理学)。主要研究领域:应激相关精神疾病的行为及脑机制研究;在上述相关领域,发表科研论文30余篇。多篇被SCI/SSCI/CSA等国际文献检索系统收录。现任中国心理学会生理心理学会专业委员会委员,中科院心理所学位委员会委员,中科院心理所实验伦理委员会委员,《心理科学进展》杂志编委。
研究领域:
应激相关精神疾病的行为及脑机制研究。
社会任职:
获奖及荣誉:
1.《大鼠成瘾易感性行为学特征及脑内相关基因表达的研究》,2005年度全国优秀博士学位论文提名。2005.12
2.《社会拥挤状态对吗啡精神兴奋性效应及其个体差异的调控》获第八届北京科学技术协会青年优秀科技论文评选二等奖。2005.12
3.《SusceptibilitytoMorphine:Highvs.LowrespondersModel》获2004-2005北京神经科学学会年会青年优秀论文奖。2005.1
4.《大鼠成瘾易感性行为学特征及脑内相关基因表达的研究》,中国科学院首届优秀博士学位论文奖。2004.10
5.中国科学院心理研究所所长奖一等奖。2003
代表论著:
(*通讯作者)
1.XigengZheng,?,OlivierDeschaux,JenniferLavigne,OphélieNachon,CarineCleren,Jean-LucMoreau,RenéGarcia,Prefrontaltetanicstimulationpreventssub-conditioningprocedure-provoked,butnotacutestress-provoked,reemergenceofextinguishedfear,NeurobiologyofLearning&Memory,2013;101:33-38(?:co-firstauthor)
2.OlivierDeschaux?,XigengZheng?,JenniferLavigne,OphélieNachon,CarineCleren,Jean-LucMoreau,RenéGarcia,Post-extinctionfluoxetinetreatmentpreventsbothsub-conditioningprocedure-provokedandacutestress-provokedreemergenceofextinguishedfear,Pychopharmacology,2013;225(1):209-216(?:co-firstauthor)
3.Xian-LiAn,Xi-GengZheng*,JingLiang,andYun-JingBai,CorticosteronecombinedwithintramedialprefrontalcortexinfusionofSCH23390impairsthestrongfearresponseinhigh-fear-reactivityrats,PsychJournal,2012(Accepted)
4.BaiYunjing,PengYonghua,LiangJing,ZhengXigeng*,DifferentialpatternsofNeuronalActivationinRostralversusCaudalVentralTegmentalAreaInvolvedinBehavioralSensitizationInducedbyanEscalatingDoseMorphineAdministrationParadigm,EuropeanJournalofPharmarcology,2012;689:118-124
5.Ding,X.,Liang,J.,Zheng,X.,Bai,Y.Liu,Z.,Li,Y.,Xing,X.,AlteredphosphorylationofGluA1inthestriatumisassociatedwithlocomotorsensitizationinducedbyexposuretoincreasingdosesofmorphine,EuropeanJournalofPharmacology,2013(accepted)
6.JingLiang,XigengZheng*;JihuanChen,YingyingLi,XiaoliXing,YunjingBai,YingcongLi,RolesofBDNF,dopamineD3receptors,andtheirinteractionsintheexpressionofmorphine-inducedcontext-specificlocomotorsensitization,EuropeanNeuropsychopharmacology,2011;21:825-834
7.JingLiang,Ji-HuanChen,Xiao-HongChen,Yong-HuaPeng,Xi-GengZheng*,Geneexpressionofconditionedlocomotionandcontext-specificlocomotorsensitizationcontrolledbymorphine-associatedenvironment,BehaviouralBrainResearch2011;216:321-331
8.YouhongLi,XigengZheng*,JingLiang,YonghuaPeng,CoexistenceofAnhedoniaandAnxiety-independentIncreasedNovelty-seekingBehaviorintheChronicMildStressModelofDepression,BehaviouralProcesses,2010;83:331-339
9.LIANGJing,PENGYongHua,GEXiaoXiang,ZHENGXiGeng*.Theexpressionofmorphine-inducedbehavioralsensitizationdependsmoreontreatmentregimenandenvironmentalnoveltythanonconditioneddrugeffects.ChineseScienceBulletin,2010;55(3):1-5
10.Bai,Y.J.,Li,Y.H.,Zheng,X.G.,Han,J.,Yang,X.Y.,Sui,N.OrexinAattenuatesunconditionedsexualmotivationinmalerats,PharmacologyBiochemistryBehavior,2009;91:581-589
11.LiYonghui,ZhengXigeng,BaiYunjing,YangXiaoyan,SuiNan,OppositeEffectsofMK-801onTheExpressionofFoodandMorphine-inducedConditionedPlacePreferenceinRats,JournalofPsychopharmacology,2006;20(1):40-46
12.YaYang?,XigengZheng?,YongfuWang,JunCao,ZhifangDong,JingxiaCai,NanSui,LinXu.StressEnablesSynapticDepressioninCA1SynapsesbyAcuteandChronicMorphine:PossibleMechanismsforCorticosteroneonOpiateAddiction,TheJournalofNeuroscience,2004;24(10):2412-20.(?:co-1stauthor)
13.ZhengXigeng,LiYonghui,LuoXiaojing,XiaoLin,WangDongmei,LiuJie,YangXiaoyan,SuiNan.Socialcrowdingsensitizeshigh-respondingratstopsychomotorstimulanteffectsofmorphinePharmacologyBiochemistryandBehavior2004;79:213-8
14.X.G.Zheng,B.P.Tan,X.J.Luo,W.Xu,X.Y.Yang,N.Sui.Novelty-seekingbehaviorandstress-inducedlocomotioninratsofjuvenileperioddifferentiallyrelatedtomorphineplaceconditioningintheiradulthoodBehaviouralProcesses2004;65(1):15-23
15.ZhengXigeng,KeXue,TanBeiping,LuoXiaojing,XuWei,YangXiaoyan,SuiNan.SusceptibilitytoMorphinePlaceConditioning:relationshipwithstress-inducedlocomotionandnovelty-seekingbehaviorinjuvenileandadultratsPharmacologyBiochemistryandBehavior2003;75:929-35
16.ZHENGXi-Geng,LIXin-Wang,YANGXiao-Yan,SUINan.Effectsofscopolamineandphysostigmineonacquisitionofmorphine-treatedratsinMorriswatermazeperformance.ActaPharmacologiaSinica2002(23)5:476-80
17.TanBeiping,ZhengXigeng,SuiNan.Effectsofrepeatedmorphineexposureonopen-fieldactivityandnoveltyseekingbehaviorinaplaygroundmazeActaPsychologiaSinica,2003;35:93-98
18.WangDM,LiJ,LiYH,ZhengXG,YangXY,SUIN,Post-traininginfusionsofdopaminereceptorantagonistintothebasolateralamygdalapreventmorphine-induceconditionedplacepreference,ActaPharmacologiaSinica,2006;27:420-420
承担科研项目情况:
1.《“围创伤期”糖皮质激素在条件性恐惧记忆消退中的作用及其与海马、杏仁核pERK及pCREB活动性的关系研究》获中科院心理所“中科院优秀博士学位论文、院长奖获得者科研启动专项资金”资助(2009.8-2011.8)
2.《PTSD条件性恐惧行为的表达及消退的多巴胺神经机制研究》,获中科院心理所“科学发展基金资助(2008.5-2010.5),项目批准号:O8CX093009
3.《中脑边缘叶多巴胺系统活动性与应激诱发的动物抑郁行为的关系研究》,获国家自然科学基金资助(2008.1-2010.12);项目批准号:30770722
4.《药物成瘾易感性大鼠脑核团定位及基因表达研究》,获国家自然科学基金资助(2005.1-2007.12);项目批准号:30470578
5.《中脑边缘叶多巴胺系统活动性与应激诱发的动物抑郁行为的关系研究》,获中国科学院《优秀博士学位论文科研启动专项资金》资助(2008.1-2010.12)。
6.《社会应激调控成瘾易感性的脑机制研究》,获中国科学院心理研究所所长研究基金资助(2003.9-2005.9);项目批准号:049。