邓宏魁 Emailhongkui_deng(at)pku(dot)edu(dot)cn；
联系电话+86-；
所在院系
实验室主页http://www.bio.pku.edu.cn/teacher_dis_oa.php?cid=146&&teaid=16


详细描述
研究方向
如何通过调控细胞命运获得多潜能干细胞和各种功能性细胞，是再生医学领域的关键问题。生命的本质是化学过程，化学小分子调控细胞命运理论上是最有效的方式。我们建立了化学小分子调控细胞命运的技术手段，首次利用化学小分子将小鼠体细胞诱导成为多潜能干细胞和功能性神经元，不仅有助于更好地理解细胞命运决定和转变机制，而且为未来再生医学治疗重大疾病带来新的可能。我们利用化学小分子首次在体外建立了具有全能性特征的干细胞（EPS细胞），该细胞具有更强的发育潜能，为体外制备各种功能成熟的细胞类型提供了更好的来源。我们将利用EPS细胞通过定向分化制备功能性的胰岛细胞、肝脏细胞、血液细胞，并结合基因编辑技术制备新型抗肿瘤的CAR-T细胞，为治疗重大疾病提供新的解决途径。
代表性科研论文
1. Xiang C, Du Y, Meng G, Soon Yi L, Sun S, Song N, Zhang X, Xiao Y, Wang J, Yi Z, Liu Y, Xie B, Wu M, Shu J, Sun D, Jia J, Liang Z, Sun D, Huang Y, Shi Y, Xu J, Lu F, Li C, Xiang K, Yuan Z, Lu S, Deng H. Science. 2019, 364(6438):399-402.
2. Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, Xu Y, Dong J, Wang C, Lai W, Zhu J, Xiong L, Zhu D, Li X, Yang W, Yamauchi T, Sugawara A, Li Z, Sun F, Li X, Li C, He A, Du Y, Wang T, Zhao C, Li H, Chi X, Zhang H, Liu Y, Li C, Duo S, Yin M, Shen H, Belmonte JC, Deng H*. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169 (2) :243-257.
3. Zhao Y, Zhao T, Guan J, Zhang X, Fu Y, Ye J, Zhu J, Meng G, Ge J, Yang S, Cheng L, Du Y, Zhao C, Wang T, Su L, Yang W, Deng H*. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming, Cell. 2015; 163, 1678-91.
4. Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H*. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013, 341 (6146) :651-4.
5. Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C, Zhao Y, Deng H*. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell. 2013, 15 3(5): 963-75.
6. Zhao T, Fu Y, Zhu J, Liu Y, Zhang Q, Yi Z, Chen S, Jiao Z, Xu X, Xu J, Duo S, Bai Y, Tang C, Li C, Deng H. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018, 23:31-45.
7. Li X, Zuo X, Jing J, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z, Zhao Y, Deng H*. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015; 17:195-203.
8. Du Y, Wang J, Jia J, Song N3 Xiang C, Xu J, Hou Z, Su X, Liu B, Jiang T, Zhao D, Sun Y, Shu J, Guo Q, Yin M, Sun D, Lu S, Shi Y, Deng H*. Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell. 2014 ;14:394-403.