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详细描述
研究方向
一、开发以质谱为核心技术的前沿方法。目前专注的研究项目为：1）单细胞蛋白质组学技术开发及其在生物医学中的应用；2）基于新型捕获离子迁移谱质谱(TIMSTOF)的糖蛋白鉴定与定量方法；3）基于碰撞横截面数值(collision cross section)的数据独立采集方法开发。 二、利用基于质谱的蛋白质组学及其他多组学技术的整合，辅以生物，化学生物学等其他跨学科领域的技术和手段，大规模地发掘基于疾病问题和临床队列的生物标志物，同时完成功能验证和机制解析。


代表性论文

1. Li, Z. Y., Huang, M., Wang, X. K., Zhu, Y., Li, J. S., Wong, C. C. L.,* Fang, Q*., Nanoliter-Scale Oil-Air-Droplet Chip-Based Single Cell Proteomic Analysis. Anal Chem, 2018, 90(8):5430-5438.
2. Tao, Z., Meng, X., Han, Y. Q.., Xue, M. M., Wu, S., Wu, P., Yuan, Y., Qiang, Z., Zhang, T.-J.* and Wong, C. C. L.,* Therapeutic Mechanism Studies of ShuFengJieDu Capsule on an Acute Lung Injury Animal Model Using Quantitative Proteomics Technology, Journal of proteome research, 2017, 16(11):4009-4019.
3. Liu, M.-Q., Zeng, W.-F., Fang, P., Cao, W.-Q., Liu, C., Yan, G.-Q., Zhang, Y., Peng, C., Wu, J.-Q., Zhang, X.-J., Tu, H.-J., Chi, H., Sun, R.-X., Cao, Y., Dong, M.-Q., Jiang, B.-Y., Huang, J.-M., Shen, H.-L., Wong, C. C. L.,* He, S.-M.* and Yang, P.-Y.* , pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and one-step mass spectrometry for intact glycopeptide identification, Nature Communications, 2017, 8(1):438
4. Hao, Q., Jiao, S., Shi, Z., Li, C., Meng, X., Wang, W., Song, X., Jiang, Z., Zhao, Y., Wong, C. C. L.,* and Zhou, Z.,* A non-canonical role of the p97 complex in RIG-I antiviral signaling, EMBO Journal, 2015, 34(23):2903-2920
5. Yan, C., Huang, J., Wan, R., Huang, M., Wong, C. C. L., and Shi, Y., Structure of a yeast Spliceosome at 3.6-angstrom resolution, Science, 2015, 349(6253):1182-1191
6. Keck, J. M., Jones, M. H., Wong, C. C. L., Binkley, J., Chen, D., Holinger, E. P., Niepel, M., Rout, M., Vogel, J., Sidow, A., Yates 3rd, J. R., and Winey, M., A Cell Cycle Phosphoproteome of the Yeast Centrosome, Science, 2011, 332(6037):1557-1561
7. Xu, T#., Wong, C. C. L.#(co-first Author), Kashina, A., and Yates 3rd, J. R., Identification of N-terminally Arginylated Proteins and Peptides by Mass Spectrometry, Nature Protocol, 2009, 4(3):325-332
8. Wong, C. C. L, Xu, T., Rai, R., Bailey, A. O., Yates 3rd, J. R., Wolf, Y. I., Zebroski, H., and Kashina, A., Global Analysis of Posttranslational Protein Arginylation, PloS Biol, 2007, 5(10), 2231-42.