陆林LIN LU Email
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详细描述
研究方向
神经精神疾病（如物质成瘾、抑郁症等）已成为二十一世纪危害人类健康的最主要疾病之一。陆林实验室研究抑郁症和药物依赖的神经生物学和临床治疗学。采用动物研究（大鼠及小鼠）及人体研究（抑郁症患者，药物成瘾者）相结合的模式，综合运用分子生物学、药理学、电生理、分子遗传学、心理学及神经影像学手段，探索（1）抑郁症和药物依赖发病后的脑内突触可塑性改变；（2）病理性记忆动态变化的分子生物学机制；（3）抑郁症和药物依赖患者的心理、认知的变化规律及其干预手段。


代表性科研论文
1. Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L. A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012; 336(6078):241-245.
2. Xue YX, Deng JH, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L. Effect of selective inhibition of reactivated nicotine-associated memories with propranolol on nicotine craving. JAMA Psychiatry. 2017; 74(3):224-232.
3. Li SX, Han Y, Xu LZ, Yuan K, Zhang RX, Sun CY, Xu DF, Yuan M, Deng JH, Meng SQ, Gao XJ, Wen Q, Liu LJ, Zhu WL, Xue YX, Zhao M, Shi J, Lu L. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects. Mol Psychiatry. 2018; 23(3):597-608.
4. Xue YX, Chen YY, Zhang LB, Zhang LQ, Huang GD, Sun SC, Deng JH, Luo YX, Bao YP, Wu P, Han Y, Hope BT, Shaham Y, Shi J, Lu L. Selective inhibition of amygdala neuronal ensembles encoding nicotine-associated memories inhibits nicotine preference and relapse. Biol Psychiatry. 2017; 82(11):781-793.
5. Luo YX, Xue YX, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L. A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. Nat Commun. 2015; 6:7675.