栗占国ZHANGUO LI Emailli99(at) bjmu (dot) edu (dot)cn
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详细描述
研究方向
长期从事风湿免疫病发病机制研究及临床诊治，主要研究方向：
（1）类风湿关节炎、红斑狼疮及干燥综合征等自身免疫病致病抗原、免疫细胞及其致病机制；
（2）自身免疫病分子标志物筛选及早期诊断方法的建立；
（3）从新型炎症因子、免疫负调控，探讨自身免疫病的新型免疫干预方法。


代表性科研论文
1. He J;Zhang X;Wei YB;Sun XL;Chen YP;Deng J;Jin YB;Gan YZ;Hu X;Jia RL;Xu CH;Hou ZH;Leong YA;Zhu L;Feng JH;An Y;Jia Y;Li C;Liu X;Ye H;Ren LM;Li R;Yao HH; Li YH ;Chen S;Zhang XW;Su Y;Guo JP;Shen N;Morand EF;Yu D;Li ZG, Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus, Nature Medicine, 22(9)(2016), 991-993.
2. Chen XJ;Sun XL;Yang W;Yang B;Zhao XZ;Chen ST;He LL;Chen H;Yang CM;Xiao L;Chang Z;Guo JP;He J;Zhang FP;Zheng F;Hu ZB;Yang ZY;Lou JZ;Zheng WJ;Qi H;Xu CQ;Zhang H;Shan HY;Zhou XJ;Wang QW;Shi Y;Lai LH;Li ZG;Liu WL, An autoimmune disease variant of IgG1 modulates B cell activation and differentiation, Science , 362(6415) (2018),700-705.
3. Liu Y;Mu R;Gao YP;Dong J;Zhu L;Ma YY;Li YH;Zhang HQ;Han D;Zhang Y;McInnes IB;Zhang JG;Shen BF;Yang G;Li ZG, A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer Cell Homeostasis and Is Shared in Several Autoimmune Diseases, Cell Host & Microbe, 19(3)(2016), 400-408.
4. Li ZG, A new look at rheumatology in China —opportunities and challenges, Nature Reviews Rheumatology, 11(5)(2015), 313.
5. He J;Tsai LM;Leong YA;Hu X;Ma CS;Chevalier N;Sun XL;Vandenberg K;Rockman S;Ding Y;Zhu L;Wei W;Wang CQ;Karnowski A;Belz GT;Ghali JR;Cook MC;Riminton DS;Veillette A;Schwartzberg PL;Mackay F;Brink R;Tangye SG;Vinuesa CG;Mackay CR;Li ZG;Yu D, Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure, Immunity, 39(4)(2013), 770-781.
6. Hu FL,Mu R,Zhu JX,Shi LJ,Li YN,Liu X,Shao WW,Li GY, Li MH, Su Y, Cohen PL,Qiu XY,Li ZG, Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis, Annals of the Rheumatic Diseases, 73(5)(2014), 928-936.
7. Wang T;Sun XL;Zhao J;ZhangJ;Zhu HQ;Li C;Gao N;Jia Y;Xu DK;Huang FP;Li NL;Lu LW;Li ZG, Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood, Annals of the Rheumatic Diseases, 74(6)(2015), 1293-1301.
8. Du, Y., Y. Cui, X. Liu, F. Hu, Y. Yang, X. Wu, X. Ma, X. Zuo, Y. Sheng, J. Xu, P. Zhu, L. Sun, N. Hong, X. Zhang, J. Guo, and Z. Li. Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol.2014; 66:822-830.