教育经历
工作经历
研究概述
发表文章
袭荣文 博士
北京生命科学研究所资深研究员
Rongwen Xi, Ph.D. Investigator, NIBS, Beijing, China
Phone：-8510
Fax：
E-mail：xirongwen@nibs.ac.cn
教育经历
Education
2002
美国肯塔基州大学生物学博士
Ph.D. in Biology, 2002，University of
1998
上海医科大学 理科硕士
Master in Science, 1998，Shanghai Medical University, China
1995
滨州医学院 临床医药学学士
B.S., Department of Clinical Medicine, 1995，Binzhou
工作经历
Professional Experience
2018-
北京生命科学研究所资深研究员
Investigator, National Institute of Biological Sciences, Beijing, China
2011-2018
北京生命科学研究所高级研究员
Associate Investigator, National Institute of Biological Sciences, Beijing, China
2006-2011
北京生命科学研究所研究员
Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2003-2006
美国思达沃医学研究所博士后
Postdoctoral Research Associate with Dr. Ting Xie at the Stowers Institute for Medical Research, USA
1998-2002
美国肯塔基州大学生物系助教，助研
Teaching Assistant, Research Assistant at the Department of Biology,University of Kentucky, USA
研究概述
成体干细胞或组织特异干细胞长期存在于多种组织和器官内，对维持机体的动态平衡及组织的再生或修复能力起决定作用。干细胞本身需要接受严格的调控，调控的紊乱可能导致癌症，衰老或退行性疾病的发生。我们实验室致力于研究组织和器官的成体干细胞在体内是如何长期维持的，它们处在一个什么样的微环境内，如何应对环境的改变，它们基因缺陷如何导致了组织和器官功能的改变和疾病的发生。在过去几年的研究中， 我们在果蝇干细胞的微环境结构，维系干细胞的信号因子及内源性的表观遗传机制等方面有了开创性的发现。这些发现为进一步理解干细胞的干性在遗传和表观遗传方面的分子机制提供了基础。另外， 我们正在建立和研究原位干细胞突变致瘤和组织再生的果蝇及小鼠模型。这些研究将对肿瘤等疾病的发生机制和防治、体外成体干细胞扩增和干细胞治疗提供理论依据和实验基础。
Research Description
Adult stem cells or named tissue-specific stem cells reside in many tissue and organs and have critical roles in maintaining normal tissue homeostasis and regeneration throughout life of each organism. Their dysfunction is believed to be intimately associated with various types of diseases such as cancer, degenerative diseases, and ageing, but the underlying mechanisms are poorly understood. My laboratory is interested in understanding how stem cells are maintained within each tissue, how do they respond to environment, and how their dysfunction leads to diseases. Over the past several years, we have made important progress on understanding the niche structure, maintenance signals, and intrinsic self-renewal mechanisms for Drosophila stem cells. These studies provide the foundation for further understanding the regulatory mechanisms of stem cell self-renewal at both genetic and epigenetic levels. In the near future, we will continue to dissect the molecular and genetic programs underlying stem cell self-renewal in Drosophila, with a new emphasis on the establishment and genetic dissection of stem cell-originated tumorigenesis as well as damage-induced tissue regeneration models in both Drosophila and mouse.
Publications:
1. Yang F*, Quan Z, Huang H, He M, Liu X, Cai T, and Xi R* (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Elife 2019 Jan 16;8. pii: e40806. doi: 10.7554/eLife.40806.
2. Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G (2018). Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants. Dev Cell. pii: S1534-5807(18)31031-1. doi: 10.1016/j.devcel.2018.11.047.5807(18)31031-1
3. Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R* (2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells. Nat Cell Biol. 20(2):152-161
4.Yin C, Xi R* (2018). A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila. Stem Cell Reports. 9;10(1):43-57. doi: 10.1016/j.stemcr.2017.11.014.
5. Huang C, Yang F, Zhang Z, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R*, Zhu B* (2017). Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila. Nat Commun. 8(1):1649. doi: 10.1038/s41467-017-01897-3.
6. Liu X, Wei W, Li X, Shen P, Ju D, Wang Z, Zhang R, Yang F, Chen C, Cao K, Zhu G, Chen H, Chen L, Sui J, Zhang E, Wu K, Wang F, Zhao L, Xi R* (2017). BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. 2017 Aug 2. pii: S0016-5085(17)35976-0. doi: 10.1053/j.gastro.2017.07.044
7. Li Y*, Pang Z, Huang H, Wang C, Cai T, Xi R* (2017). Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells. Sci Rep. 20;7(1):988. doi: 10.1038/s41598-017-01138-z.
8. Yang F, Xi R* (2017). Silencing transposable elements in the Drosophila germline. Cell Mol Life Sci. 74(3):435-448 Review.
9. Chen J., Li J., Huang H. and Xi R*. (2016). Gene Expression Analysis of Sorted Cells by RNA-seq in Drosophila Intestine. Bio-protocol 6(24): e2079. DOI: 10.21769/BioProtoc.2079
10.Li X, Yang F, Chen H, Deng B, Li X, Xi R* (2016). Control of germline stem cell differentiation by polycomb and trithorax group genes in the niche microenvironment. Development. 143(19):3449-3458 pii: dev.137638.
11.Chen J, Xu N, Huang H, Cai T, Xi R* (2016). A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis. Elife. 5. pii: e14330. doi: 10.7554/eLife.14330
12.Wang C, Xi R* (2015). Keeping intestinal stem cell differentiation on the Tramtrack. Fly (Austin). 14:0.
13.Hu Z, Hu Y, Liu X, Xi R, Zhang A, Liu D, Xie Q, Chen L (2015). Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor. Oncotarget. 6(31):31628-39
14.Wang C, Guo X, Dou K, Chen H, Xi R* (2015). Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. Development 142(19):3321-31
15.Yang F, Zhao R, Fang X, Huang H, Xuan Y, Ma Y, Chen H, Cai T, Qi Y, Xi R* (2015). The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep. 16(8):965-74
16.Guo X, Chen J, Li Z and Xi R* (2015). Signaling Pathways Regulating Stem Cells (Book Chapter) in R.C.Zhao (ed.), Stem Cells: Basics and Clinical Translation, Translational Medicine Research 1. Shanghai Jiaotong University Press, Shanghai and Springer Science+Business Media Dordrecht.
17.Wang C, Guo X, Xi R* (2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple cell lineage differentiation of Drosophila gastric stem cells. Cell Research 24(5):610-27
18.Quan Z, Sun P, Lin G, Xi R* (2013). TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation via Rheb-TORC1-S6K but independent of nutrition status or Notch regulation. J Cell Sci. 126:3884-92
19.Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R* (2013). APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression. Developmental Biology 378(2):122-40
20.Lin G, Zhang X, Ren J, Pang Z, Wang C, Xu N, Xi R* (2013). Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila. Developmental Biology377(1):177-87
21.Wen P, Quan Z, Xi R* (2012). The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. Developmental Dynamics 241(3):455-64
22.Xu N, Wang SQ, Tan D, Gao Y, Lin G, Xi R* (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Developmental Biology 354(1):31-43
23.Su Y, Deng B, Xi R* (2011). Polycomb group genes in stem cell self-renewal: a double-edged sword. Epigenetics. 6(1):16-9.
24.Sun P, Quan Z, Zhang, B, Wu T, Xi R* (2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation. Development 137(15):2461-9
25.Wen P, Sun P, Xi R* (2010). Stem cell niche (book chapter) in “Regenerative Medicine – From Protocol to Patient”. The Springer Press.
26.Li X, Han Y, Xi R* (2010). Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes & Development 24(9):933-46.
27.Zhao R, Xi R* (2010). Stem Cell Competition for Niche Occupancy: Emerging Themes and Mechanisms. Stem Cell Rev. 6(3):345-50
28.Lin G, Xu N, Xi R* (2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol 2(1): 37-49.
29.Xi, R* (2009). Anchoring stem cells in the niche by cell adhesion molecules. Cell Adh Migr 3(4): 396-401.
30.Lin G, Xi R* (2008) Intestinal stem cell, muscular niche and wingless signaling. Fly (Austin). 2(6): 310-2.
31.Lin G, Xu N, Xi R* (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 455(7216):1119-23.
32.Zhao R, Xuan Y, Li X, Xi R* (2008). Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila. Aging Cell 7(3):344-54.
33.Xi R, Xie T (2005). Stem cell self-renewal controlled by chromatin remodeling factors. Science310(5753):1487-9.
34.Xi R, Doan C, Liu D, Xie T (2005). Pelota controls self-renewal of germline stem cells by repressing a bam-independent differentiation pathway. Development 132(24):5365-74.
35.Xi R, Kirrily D, Xie T (2005). Molecular mechanisms controlling germline and somatic stem cells: similarities and differences (review). Curr Opin Genet Dev. 15(4):381-7.
36.Rawlings JS, Rennebeck G, Harrison SM, Xi R, Harrison DA (2004). Two Drosophila Suppressors of Cytokine Signaling (SOCS) differentially regulate JAK and EGFR pathway activities. BMC Cell Biol. 15;5(1):38.
37.Song X, Wong, MD, Kawase E, Xi R, Ding BC, McCarthy J, Xie T (2004). BMP signaling from the niche directly represses the transcription of a differentiating gene, bag of marbles, in the germline stem cells of Drosophila ovary. Development 131(6):1353-64.
38.Xi R, McGregor JR, Harrison DA (2003). A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Developmental Cell 4(2):167-77.
39.McGregor JR, Xi R, Harrison DA (2002). JAK signaling is somatically required for follicle cell differentiation in Drosophila. Development 129(3):705-17.
