1. 北京科技大学冶金与生态工程学院,北京 100083 2. 中国科学院过程工程研究所生化工程国家重点实验室,北京 100190
收稿日期:
2018-10-30修回日期:
2018-12-12出版日期:
2019-08-22发布日期:
2019-08-15通讯作者:
金泉基金资助:
牙槽窝填充用组织功能化纳米羟基磷灰石制备及应用研究;表/界面优化的氧化铈多壳层空心结构的构筑及催化性能研究;氧化物半导体复合纳米贵金属的界面微观结构调控及其协同催化性能研究;金属氧化物赝电容电极材料的介尺度多级结构设计与控制合成Preparation and properties of porous hydroxyapatite for orbital implants
Zhenling SHI1, Mei YANG2*, Quan JIN2, Dan MAO2, Nan XU2, Ranbo YU1*1. School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083, China 2. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
Received:
2018-10-30Revised:
2018-12-12Online:
2019-08-22Published:
2019-08-15摘要/Abstract
摘要: 采用均相共沉淀法直接合成了高纯度羟基磷灰石粉体,通过改变反应物加入方式和反应时间调控粉体形貌和组成,分析了体系pH值对产物纯度的影响;以硅溶胶为粘结剂、尿素为造孔剂,室温下压制成型,高温烧结制备了孔隙度高、力学性能良好的多孔羟基磷灰石块体,考察了粉体粒径、造孔剂含量对孔隙度和抗压强度等性能的影响。结果表明,纳米粉有利于块体成型,随造孔剂含量增加,块体密度减小、孔隙度增加,当羟基磷灰石与尿素质量比为1.5:1时,孔隙度达69%,抗压强度达8 MPa,满足义眼台应用需求。
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时振领 杨梅 金泉 毛丹 徐楠 于然波. 义眼台用羟基磷灰石的制备和性能[J]. 过程工程学报, 2019, 19(4): 767-774.
Zhenling SHI Mei YANG Quan JIN Dan MAO Nan XU Ranbo YU . Preparation and properties of porous hydroxyapatite for orbital implants[J]. Chin. J. Process Eng., 2019, 19(4): 767-774.
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参考文献
[1] Harun WSW, Asri RIM, Alias J, et al. A comprehensive review of hydroxyapatite-based coatings adhesion on metallic biomaterials [J]. Ceramics International, 2018, 44(2): 1250-1268. [2] Zhou H, Lee J. Nanoscale hydroxyapatite particles for bone tissue engineering [J]. Acta Biomaterialia, 2011, 7(7): 2769-2781. [3] Suchanek W, Yoshimura M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants [J]. Journal of Materials Research, 1998, 13(1): 94-117. [4] Shah S U, Shields C L, Lally S E, et al. Hydroxyapatite orbital implant in children following enucleation: analysis of 531 sockets [J]. Ophthalmic Plastic and Reconstructive Surgery, 2015, 31(2): 108-114. [5] Thiesmann R. Motility and lid changes with coralline hydroxyapatite orbital implants and cryolite glass ocular prostheses [J]. Ophthalmologe, 2018, 115(9): 794-795. [6] Rubin P, Popham JK, Bilyk JR, et al. Comparison of fibrovascular ingrowth into hydroxyapatite and porous polyethylene orbital implants [J]. Ophthalmic Plastic and Reconstructive Surgery, 1994, 10(2): 96-103. [7] 聂玉红,邢怡桥,郭颖等. 羟基磷灰石义眼台植入后暴露原因分析及处理[J]. 眼科新进展, 2006, 26(9): 691-693. Nie YH, Xing YQ, Guo Y, et al. Analysis on the causes and management of exposure of orbital hydroxyapatite implants [J]. Recent Advances in Ophthalmology, 2006, 26(9): 691-693. [8] Shields CL, Uysal Y, Marr B, et al. Experience with the polymer-coated hydroxyapatite implant after enucleation in 126 patients [J]. Ophthalmology, 2007, 114(2): 367-373. [9] Chalasani R, Poole-Warren L, Conway RM, et al. Porous orbital implants in enucleation: A systematic review [J]. Survey of Ophthalmology, 2007, 52(2): 145-155. [10] Dutton JJ. Coralline hydroxyapatite as an ocular implant [J]. Ophthalmology, 1991, 98(3):370-377. [11] Sun R-X, Lv Y, Niu Y-R, et al. Physicochemical and biological properties of bovine-derived porous hydroxyapatite/collagen composite and its hydroxyapatite powders [J]. Ceramics International, 2017, 43(18):16792–16798. [12] Hong Y,Fan H,Li B, et al. Fabrication, biological effects, and medical applications of calcium phosphate nanoceramics [J]. Materials Science & Engineering R, 2010, 70(3): 225-242 [13] Wang J, Zhu Y, Wang M, et al. Fabrication and preliminary biological evaluation of a highly porous biphasic calcium phosphate scaffold with nano-hydroxyapatite surface coating [J]. Ceramics International, 2018, 44(3): 1304-1311. [14] Liu R, Xu T, Wang CA. A review of fabrication strategies and applications of porous ceramics prepared by freeze-casting method [J]. Ceramics International, 2015, 42(2): 2907–2925. [15] Deville S, Saiz E, Tomsia AP. Freeze casting of hydroxyapatite scaffolds for bone tissue engineering [J]. Biomaterials, 2006, 27(32): 5480-5489. [16] Liu B, Lin P, Shen Y, et al. Porous bioceramics reinforced by coating gelatin [J]. Journal of Materials Science: Materials in Medicine, 2008, 19(3): 1203-1207. [17] 巩梦安, 饶群力, 王鸿烈. 造孔剂和发泡剂结合法制备氟化羟基磷灰石多孔支架研究[J]. 无机材料学报,2014, 29(3): 289-293. Gong M A, Rao Q L, Wang H L. A novel technique to prepare porous 3D fluoridated hydroxyapatite scaffold using pore-forming and foaming agents [J]. Journal of Inorganic Materials, 2014, 29(3): 289-293. [18] 辛晨, 齐鑫, 朱敏等. 三维打印羟基磷灰石晶须增强复合骨修复支架[J]. 无机材料学报,2017, 32(8): 837-844. Xin C, Qi X, Zhu M,et al. Hydroxyapatite whisker-reinforced composite scaffolds through 3D printing for bone repair [J]. Journal of Inorganic Materials, 2017, 32(8): 837-844. [19] Bigi A, Boanini E, Rubini K. Hydroxyapatite gels and nanocrystals prepared through a sol-gel process [J]. Journal of Solid State Chemistry, 2004, 177(9): 3092-3098. [20] Choi D, Kumta P N. An alternative chemical route for the synthesis and thermal stability of chemically enriched hydroxyapatite [J]. Journal of the American Ceramic Society, 2006, 89(2): 444-449. [21] Guo X, Xiao P, Liu J, et al. Fabrication of nanostructured hydroxyapatite via hydrothermal synthesis and spark plasma sintering [J]. Journal of the American Ceramic Society, 2005, 88(4): 1026-1029. [22] Sadat-Shojai M, Khorasani MT, Dinpanah-Khoshdargi E, et al. Synthesis methods for nanosized hydroxyapatite with diverse structures[J]. Acta Biomaterialia, 2013, 9(8): 7591-7621. [23] Aizawa M, Ueno H, Itatani K, et al. Syntheses of calcium-deficient apatite fibres by a homogeneous precipitation method and their characterizations [J]. Journal of European Ceramic Society, 2006, 26(4-5): 501-507. [24] Zhu R, Lai X, Halpert J E, et al. Hierarchical hydroxyapatite microspheres composed of nanorods and their competitive sorption behavior for heavy metal ions [J]. European Journal of Inorganic Chemistry, 2012, 43(36):2665-2668. [25] Zhu R, Yu R, Yao J, et al. Morphology control of hydroxyapatite through hydrothermal process [J]. Journal of Alloys and Compounds, 2008, 457(1-2): 555-559. [26] Uskokovic V, Uskokovic D P. Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents [J]. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2011, 96B(1): 152-191. |
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