Improving the Cpf1-mediated base editing system by combining dCas9/dead sgRNA with human APOBEC3A va

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Meng Lian1, 2, 1,
Fangbing Chen3, 4, 1,
Xingyun Huang3, 4, 1,
Xiaozhu Zhao3, 4,
Shixue Gou3, 4,
Nan Li3, 4,
Qin Jin3, 4,
Hui Shi3, 4,
Yanhui Liang3, 4,
Jingke Xie3, 4,
Weikai Ge3, 4,
Zhenpeng Zhuang3, 4,
Jiaowei Wang3, 4,
Yinghua Ye5, 6, 7,
Yi Yang8,
Kepin Wang9, 10, 11 ,
Liangxue Lai9, 10, 11 ,
Han Wu9, 10, 11
1CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
2Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, China
3CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
4University of Chinese Academy of Sciences, Beijing 100049, China
5CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
6Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou 510530, China
7Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China
8Key Laboratory for Major Obstetrics Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Hospital Affiliated of Guangzhou Medical University, Guangzhou 510150, China
9CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
10Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou 510530, China
11Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China

More InformationCorresponding author: E-mail address: wang_kepin@gibh.ac.cn (Kepin Wang);E-mail address: lai_liangxue@gibh.ac.cn (Liangxue Lai);E-mail address: wu_han@gibh.ac.cn (Han Wu)
Publish Date:2021-01-20

Abstract

PDF全文下载地址:

http://www.jgenetgenomics.org/article/exportPdf?id=68944b27-11a6-4734-ad5c-a17f26566b00&language=en

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