Xinxin Tian
Mengxi Lu
Zhiqian Zhang
aDepartment of Immunology and Microbiology, Basic Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
bTianjin International Joint Academy of Biomedicine, Tianjin 300457, China
cDepartment of Biochemistry and Biophysics, Texas A&M University and Texas AgriLife Research, College Station, TX 77843-2128, USA
dNorth China University of Science and Technology, Tangshan 063210, China
eState Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
More InformationCorresponding author: E-mail address: zhangzhiqian@tjab.org (Zhiqian Zhang)
Received Date: 2017-10-10
Accepted Date:2018-03-04
Rev Recd Date:2018-03-01
Available Online: 2018-03-06 Publish Date:2018-03-20
Abstract
Abstract
Long non-coding RNAs (lncRNAs) have been reported to be of great importance in tumorigenesis and progression of a variety of cancers. However, the role of lncRNAs in ovarian cancer (OC) remains largely unknown. In the present study, we identified a novel lncRNA, LOC100288181 (named as Lnc-OC1), which acted as a key regulator in the development and progression of OC. The combined Gene Expression Omnibus (GEO) database analysis revealed that Lnc-OC1 was significantly upregulated in OC tissues and Kaplan-Meier survival analysis confirmed that high Lnc-OC1 expression was associated with poor prognosis of OC patients. Importantly, we also demonstrated that knockdown of Lnc-OC1 suppressed cell proliferation, colony formation, invasion and migrationin?vitro and inhibited tumorigenicity in?vivo. Mechanistically, Lnc-OC1 repressed the expression of endogenous miR-34a and miR-34c as a sponge and vice versa. Moreover, rescue experiments demonstrated that the oncogenic function of Lnc-OC1 at least partially depended on suppressing miR-34a and miR-34c. In conclusion, our results suggest that the Lnc-OC1-miR-34a/34c axis may play a pivotal role in OC, and may serve as a potential diagnostic biomarker and a powerful therapeutic target for OC.Keywords: Ovarian cancer,
Lnc-OC1,
miR-34a,
miR-34c,
Tumorigenicity
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