程祝宽
职称：研究员

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研究方向：植物分子细胞遗传


程祝宽，博士，研究员，博士生导师
E-mail: zkcheng@genetics.ac.cn; Telephone: 010-6480, 6551
1987年获扬州大学农学系农学学士，1990年获扬州大学农学系作物遗传育种硕士，1999年获中国科学院遗传研究所理学博士，1999年至2002年在美国Wisconsin-Madison大学从事博士后研究。2002年12月入选中国科学院“****”，终期考核为优秀。2003年获国家****基金资助，担任过Chromosome Research、Frontiers in Plant Science、JGG、PLoS One等杂志编委。

主要研究方向——植物减数分裂的遗传调控机制
减数分裂是真核生物有性生殖过程中发生的核心事件，对于有性生殖有着极其重要的意义。一方面，减数分裂产生染色体数目减半的配子，它们通过雌雄配子受精结合，维系了亲代与子代之间染色体数目的恒定。另一方面，减数分裂过程中同源染色体的非姊妹染色单体间发生交换，以及非同源染色体间的自由组合，使得遗传物质在双亲之间充分交流，增加了杂交后代的遗传多样性，亦为自然或人工选择提供丰富的基础材料。
水稻是重要的粮食作物，同时也是单子叶植物分子生物学研究的模式生物。其基因组只有430 Mb，是粮食作物中最小的。加之成熟的遗传转化体系、相对完善的基因组信息以及适中的染色体大小和数目，水稻已日渐成为减数分裂研究的理想材料。到目前为止，我们以水稻为模式植物，克隆了30多个参与减数分裂起始、同源染色体配对、联会、重组、分离等关键事件的功能基因，初步构建了水稻减数分裂遗传调控的基因网络。与酵母、哺乳动物以及拟南芥相比，水稻减数分裂基因功能具有很强的保守性，但有些基因也会有明显的功能分化。例如水稻联会复合体横丝蛋白基因ZEP1，该基因突变导致重组频率显著提高，这与其它物种相比有很大差别。另外，水稻SDS基因参与了DSB的形成，而在拟南芥中SDS并不参与DSB的形成，说明物种之间减数分裂调控机制可能存在一定的差异。
对减数分裂调控机制研究的深入，便可能通过基因工程手段实现对减数分裂过程的遗传调控，更好地服务于育种实践。例如，通过增加重组频率，更容易打破遗传累赘，缩短育种周期，提高育种效率。随着基因编辑手段在减数分裂突变体创制中的应用，以及减数分裂相关蛋白生化功能研究的深入，结合超高分辨显微技术、活体成像技术、单细胞测序技术等，对减数分裂调控机制的解析将愈加深入，相应遗传工程应用也会更有成效。
Corresponding Author
1.Zhao TT, Ren LJ, Chen XJ, Yu HX, Liu CJ, Shen Y, Shi WQ, Tang D, Du GJ, Li YF, Ma BJ, Cheng ZK (2018). A type-B response regulator, LEPTO1, is essential for setting up leptotene status in rice meiosis. Plant Cell (accepted).
2.Zhang C, Shen Y, Tang D, Shi WQ, Zhang DM, Du GJ, Zhou YH, Liang GH, Li YF, Cheng ZK (2018). The Zinc Finger Protein DCM1 is Required for Male Meiotic Cytokinesis by Preserving Callose in RiceThe Zinc Finger Protein DCM1 is Required for Male Meiotic Cytokinesis by Preserving Callose in Rice. PLoS Genet. 10: DOI:10.1371/journal.pgen.**.
3.Li YF, Qin BX, Shen Y, Zhang FF, Liu CZ, You HL, Du GJ, Tang D, Cheng ZK (2018). HEIP1 Regulates Crossover Formation during Meiosis in Rice, PNAS, 2018, DOI:10.1073/pnas. .
4.Liu CZ, Xue ZH, Tang D, Shen Y, Shi WQ, Ren LJ, Du GJ, Li YF, Cheng ZK (2018). Ornithine？d-aminotransferase is critical for floret development and seed setting through mediating nitrogen reutilization in rice, Plant J, 2018, doi: 10.1111/tpj.14072.
5.Ren LJ, Tang D, Zhao TT, Zhang FF, Liu CZ, Xue ZH, Shi WQ, Du GJ, Shen Y, Li YF, Cheng ZK (2018).OsSPLregulates meiotic fate acquisition in rice.New Phytologist 218: 789–803.
6.Wu ZG, Tang D, Liu K, Miao CB, Zhuo XX, Li YF, Tan XL, Sun MF, Luo Q, Cheng ZK (2018). Characterization of a new semi-dominant dwarf allele of SLR1 and its potential application in hybrid rice breeding. JXB. 69: 4703-4713.
7.Wu ZG, Fang DM, Yang R, Gao F, An XY, Zhuo XX 1, Li YF, Yi CD, Zhang T, Liang CZ, Cui P, Cheng ZK, Luo Q (2018). De novo genome assembly of Oryza granulata reveals rapid genome expansion and adaptive evolution. Communications Biology 1: DOI:10.1038/s42003-018-0089-4.
8.Hu Q, Zhang C, Xue ZH, Ma LJ, Liu W, Shen Y, Ma B, Cheng ZK (2018). OsRAD17 is required for meiotic double-strand break repair and plays a redundant role with OsZIP4 in synaptonemal complex assembly. Front. Plant Sci. 9:1236. doi: 10.3389/fpls. 2018.01236.
9.Zhang F, Tang D, Shen Y, Xue ZH, Shi WQ, Ren LJ, Du GJ, Li Y, Cheng ZK (2017). The F-box protein ZYGO1 mediates bouquet formation to promote homologous pairing, synapsis, and recombination in rice meiosis. Plant Cell 29: 2597-2609.
10. Hu Q, Li YF, Wang HJ, Shen Y, Zhang C, Du GJ, Tang D, Cheng ZK (2017). Meiotic chromosome association 1 interacts with TOP3a and regulates meiotic recombination in rice. Plant Cell 29: 1697-1708.
11. Ji JH, Tang D, Shen Y, Xue ZH, Wang HJ, Shi WQ, Zhang C, Du GJ, Li YF, Cheng ZK (2016). P31^comet, a Member of the Synaptonemal Complex, Participates in Meiotic DSB Formation in Rice. Proc Natl Acad Sci U S A. 113: 10577-10582.
12. Xin Q, Shen Y, Li X, Lu W, Wang X, Han X, Dong FM, Wan LL, Yang GS, Hong DF, Cheng ZK (2016). MS5 mediates early meiotic progression and its natural variants may have applications for hybrid production in Brassica napus. Plant Cell 25: 1263-1278.
13. Wang HJ, Hu Q, Tang D, Liu XF, Du GJ, Shen Y, Li YF, Cheng ZK (2016). OsDMC1 is not required for homologous pairing in rice meiosis. Plant Physiol. 171: 230-41.
14. Hu Q, Tang D, Wang HJ, Shen Y, Chen XJ, Ji JH, Du GJ, Li YF, Cheng ZK (2016). The exonuclease homolog OsRAD1 promotes accurate meiotic double-strand break repair by suppressing non-homologous end joining. Plant Physiol. 172: 1105-1116.
15. Xue ZH, Li YF, Zhang L, Shi WQ, Zhang C, Feng MS, Zhang FF, Tang D, Yu HX, Gu MH, Cheng ZK (2016). OsMTOPVIB Promotes Meiotic DNA Double-Strand Break Formation in Rice. Molecular Plant. 9: 1535-1538.
16. Liu XF, Li M, Liu K, Tang D, Sun MF, Li YF, Shen Y, Du GJ, Cheng ZK (2016). Semi-Rolled Leaf2 modulates rice leaf rolling by regulating abaxial side cell differentiation. JXB. 67: 2139-50.
17. Yang R, Li YF, Su Y, Tang D, Luo Q, Cheng ZK (2016). A functional centromere lacking CentO sequences in a newly formed ring chromosome in rice. Journal of Genetics and Genomics. 43: 694-701.
18. Li Y, Cheng ZK (2016). Fluorescence in situ hybridization on rice chromosomes. Methods in Molecular Biology, 1370: 105-112.
19. Wu ZG, Ji JH, Tang D, Wang HJ, Shen Y, Shi WQ, Li YF, Tan XL, Cheng ZK, Luo Q (2015). SDS is essential for DSB formation in rice meiosis. Front. Plant Sci. 6: 21.
20. Zhang BW, Wang M, Tang D, Li YF, Xu M, Gu MH, Cheng ZK, Yu HX (2015). XRCC3 is essential for faithful DSB repair and homologous recombination in rice meiosis. JXB. 66: 5713-5725.
21.Che LX, Wang KJ, Tang D, Liu QQ, Chen XJ, Hu Q, Shen Y, Yu HX, Gu MH, Cheng ZK (2014). OsHUS1 facilitates accurate meiotic recombination in rice. PLoS Genet. 10: e**.
22.Tang D, Miao CB, Li YF, Wang HJ, Liu XF, Yu HX, Cheng ZK (2014). OsRAD51C is essential for double-strand break repair in rice meiosis. Front. Plant Sci. 5:167. doi: 10.3389/fpls. 2014. 00167
23.Luo Q, Li YF, Shen Y, Cheng ZK (2014). Ten years of gene discovery for meiotic event control in rice. Journal of Genetics and Genomics. 41:125-137.
24.Zhang L, Tang D, Luo Q, Chen XJ, Wang HJ, Li YF, Cheng ZK (2014). Crossover formation during rice meiosis relies on interaction of OsMSH4 and OsMSH5. Genetics. 198: 1447-1456.
25.Cheng ZK (2013). Analyzing meiotic chromosomes in rice. In Methods in Molecular Biology: Plant Meiosis. 990: 125-134.
26.Miao CB, Tang D, Zhang HG, Wang M, Tang SZ, Yu HX, Gu MH, Cheng ZK (2013). CRC1, a novel synaptonemal complex component, is essential for meiotic recombination initiation in rice. Plant Cell. 25: 2998-3009.
27.Ji JH, Tang D, Wang M, Li YF, Zhang L, Wang KJ, Li M, Cheng ZK (2013). MRE11 is required for homologous synapsis and DSB processing in rice meiosis. Chromosoma. 122: 363–376.
28.Wu XR, Tang D, Li M, Wang KJ, Cheng ZK (2013). Loose plant architecture 1, an INDETERMINATE domain protein involved in shoot gravitropism, regulates plant architecture in rice. Plant Physiology. 161: 317-329.
29.Luo Q, Tang D, Wang M, Luo WX, Zhang L, Qin BX, Shen Y, Wang KJ, Li YF, Cheng ZK (2013). The role of OsMSH5 in crossover formation during rice meiosis. Molecular Plant 6: 729-742.
30.Wang M, Tang D, Luo Q, Jin Y, Shen Y, Wang KJ, Cheng ZK (2012). BRK1, a Bub1-related kinase, is essential for generating proper tension between homologous kinetochores at metaphase I of rice meiosis. Plant Cell.24: 4961-4973.
31.Wang K, Wang M, Tang D, Shen Y, Hu Q, Miao C, Lu T, Cheng ZK (2012). The role of rice HEI10 in the formation of meiotic crossovers. PLoS Genet 8: e**.
32.Hong LL, Tang D, Zhu KM, Wang KJ, Li M, Cheng ZK (2012). Somatic and reproductive cell development in rice anther is regulated by a putative gutaredoxin. Plant Cell 24: 577-588.
33.Shen Y, Tang D, Wang KJ, Wang M, Huang J, Luo WX, Luo Q, Hong LL, Li M, Cheng ZK (2012). The role of ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis. Journal of Cell Science 125: 2581-2591.
34.Ji JH, Tang D, Wang KJ, Wang M, Che LX, Li M, Cheng ZK (2012). OsCOM1 deficiency results in defective homologous recombination and in aberrant recombination between nonhomologous chromosomes in rice meiosis. The Plant Journal 72: 18-30.
35.Hong LL, Tang D, Shen Y, Hu Q, Wang KJ, Li M, Lu TG, Cheng ZK (2012).MIL2 regulates early cell differentiation in the rice anther. New Phytologist 196: 402-413.
36.Hong LL, Qian Q, Tang D, Wang KJ, Li M, Cheng ZK (2012). A mutation in the rice chalcone isomerase gene causes the golden hull and internode1 phenotype. Planta 236: 141-151.
37.Shao T, Qian Q, Tang D, Chen J, Li M, Cheng ZK, Luo Q. (2012). A novel gene IBF1 is required for the inhibition of brown pigment deposition in rice hull furrows. Theor. Appl. Genet. 125: 381-390.
38.Wang M, Tang D, Wang KJ, Shen Y, Qin BX, Miao CB, Li M, Cheng ZK (2011).OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis. The Plant Journal 67: 583-594.
39.Shao T, Tang D, Wang KJ, Wang M, Che LX, Qin BX, Yu HX, Li M, Gu MH, Cheng ZK (2011). OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis. Plant Physiol. 156: 1386-1396.
40.Qin BX, Tang D, Huang J, Li M, Wu XR, Lu LL, Wang KJ, Yu HX, Chen JM, Gu MH, Cheng ZK (2011). Rice OsGL1-1 is involved in leaf cuticular wax and cuticle membrane. Molecular Plant 4: 985-995.
41.Li M, Tang D, Wang KJ, Wu XR, Lu LL, Yu HX, Gu MH, Yan CJ, Cheng ZK (2011). Mutations in the F-box gene LARGER PANICLE improve the panicle architecture and enhance the grain yield in rice. Plant Biotechnology Journal 9: 2001-2012.
42.Wang KJ, Wang M, Tang D, Shen Y, Qin BX, Li M, Cheng ZK (2011). PAIR3, an axis-associated protein, is essential for the recruitment of recombination elements onto meiotic chromosomes in rice. Mol. Biol. Cell 22: 12-19.
43.Che LX, Tang D, Wang KJ, Wang M, Zhu KM, Yu HX, Gu MH, Cheng ZK (2011). OsAM1 is required for leptotene-zygotene transition in rice. Cell Research 21: 654-665.
44.Yu HX, Wang M, Tang D, Wang KJ, Chen FL, Gong ZY, Gu MH, Cheng ZK (2010). OsSPO11-1 is essential for both homologous chromosome pairing and crossover formation in rice. Chromosoma 119: 625-636.
45.Wang M, Wang KJ, Tang D, Wei CX, Li M, Shen Y, Chi ZC, Gu MH, Cheng ZK (2010). The central element protein ZEP1 of the synaptonemal complex regulates the number of crossovers during meiosis in rice. Plant Cell 22: 417-430.
46.Wang KJ, Tang D, Hong LL, Xu WY, Huang J, Li M, Gu MH, Xue YB, Cheng ZK (2010). DEP and AFO regulate reproductive habit in rice. PLoS Genet. 6: e**.
47.Zhu KM, Tang D, Yan CJ, Chi ZC, Yu HX, Chen JM, Liang JS, Gu MH, Cheng ZK (2010). ERECT PANICLE2 encodes a novel protein that regulates panicle erectness in indica rice. Genetics 184: 343-350.
48.Hong LL, Qian Q, Zhu KM, Tang D, Huang ZJ, Gao L, Li M, Gu MH, Cheng ZK (2010). ELE restrains empty glumes from developing into lemmas. J. Genet. Genomics 37: 101-115.
49.Huang J, Tang D, Shen Y, Qin BX, Hong LL, You AQ, Li M, Wang X, Yu HX, Gu M, Cheng ZK (2010). Activation of gibberellin 2-oxidase 6 decreases active gibberellin levels and creates a dominant semi-dwarf phenotype in rice (Oryza sativa L.). J. Genet. Genomics 37: 23-36.
50.Wang KJ, Tang D, Wang M, Lu JF, Yu HX, Liu JF, Qian BX，Gong ZY, Wang X, Chen JM, Gu MH, Cheng ZK (2009). MER3 is required for normal meiotic crossover formation, but not for presynaptic alignment in rice. Journal of Cell Science 122: 2055-2063.
51.Li M, Xiong GY, Li R, Cui JJ, Tang D, Zhang BC, Pauly M, Cheng ZK, Zhou YH (2009). Rice cellulose synthase-like D4 is essential for normal cell-wall biosynthesis and plant growth. The Plant Journal 60: 1055-1069.
52.Huang J, Zhang KW, Shen Y, Huang ZJ, Li M, Tang D, Gu MH, Cheng ZK (2009). Identification of a high frequency transposon induced by tissue culture, nDaiZ, a member of the hAT family in rice. Genomics 93: 274-281.
53.Zhang DF, Yang QY, Ding Y, Cao XF, Xue YB, Cheng ZK (2008). Cytological characterization of the tandem repetitive sequences and their methylation status in the Antirrhinum majus genome. Genomics 92: 107-114.
54.Yu HX, Wang X, Gong ZY, Tang D, Gu MH, Cheng ZK (2008). Generating of rice OsCENH3-GFP transgenic plants and their genetic applications. Chinese Science Bulletin 53: 2981-2988.
55.Cui JJ, Fan SC, Shao T, Huang ZJ, Zheng DL, Tang D, Li M, Qian Q, Cheng ZK (2007). Characterization and fine mapping of the ibf mutant in rice. J. Integr. Plant Biol. 49: 678-685.
56.Tang XM, Bao WD, Zhang WL, Cheng ZK (2007). Identification of chromosomes from multiple rice genomes using a universal molecular cytogenetic marker system. J. Integr. Plant Biol. 49: 953-960.
57.Zhang KW, Qian Q, Huang ZJ, Wang YQ, Li M, Hong LL, Zheng DL, Gu MH, Chu CC, Cheng ZK (2006). GOLD HULL AND INTERNODE2 (GH2) encodes a primarily multifunctional cinnamyl-alcohol dehydrogenase (CAD) in Oryza sativa. Plant Physiol. 140: 972-983.
58.Bao WD, Zhang WL, Yang QY, Zhang Y, Han B, Gu MH, Xue YB, Cheng ZK (2006). Diversity of centromeric repeats in two closely related wild rice species, O. officinalis and O. rhizomatis. Mol. Gen. Genomics 275: 421-430.
59.Zhang WL, Yi CD, Bao WD, Liu B, Cui JJ, Yu HX, Cao XF, Gu MH, Liu M, Cheng ZK (2005). The transcribed 165bp CentO satellite is the major functional centromeric element in the wild rice species Oryza punctata. Plant Physilol. 139: 306-315.
60.Zhang DF, Yang QY, Bao WD, Zhang Y, Han B, Xue YB, Cheng ZK (2005). Molecular cytogenetic characterization of the Antirrhinum majus genome. Genetics 169: 325-335.
Co-author
61. Wang D, Qin BX, Li X, Tang D, Zhang YE, Cheng ZK, Xue YB (2016). Nucleolar DEAD-box RNA helicase TOGR1 regulates thermotolerant growth as a pre-rRNA chaperone in rice. PLoS Genetics. 12: e**.
62. Zhang BW, Xu M, Bian SQ, Hou LL, Tang D, Li YF, Gu MH, Cheng ZK, Yu HX (2015). Global identification of genes specific for rice meiosis. PLoS One. 10: e**.
63.Zhang J, Liu XQ, Li SY,Cheng ZK, Li CY (2014). The rice semi-dwarf mutant sd37, caused by a mutation in CYP96B4, plays an important role in the fine-tuning of plant growth. PLoS One. 9: e88068.
64. Yang CH,Li DY,Liu X,Ji CJ,Hao LL,Zhao XF,Li XB,Chen CY,Cheng ZK,Zhu LH (2014). OsMYB103L, an R2R3-MYB transcription factor, influences leaf rolling and mechanical strength in rice (Oryza sativa L.). BMC Plant Biology.14:158.
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66.Xu J, Sun XJ, Jing YD, Wang M, Liu K, Jian YL, Yang M, Cheng ZK, Yang CL (2012). MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells. Cell Research 22: 886-902.
67.Xu CH, Cheng ZK, Yu WC (2012). Construction of rice minichromosomes by telomere mediated chromosomal truncation. The Plant Journal 70: 1070-1079.
68.Li J, Jiang JF, Qian Q, Xu YY, Zhang C, Xiao J, Du C, Luo W, Zou GX, Chen ML, Huang YQ, Feng YQ, Cheng ZK, Yuan M, Chong K (2011). Mutation of rice BC12/GDD1, which encodes a kinesin-like protein that binds to a GA biosynthesis gene promoter, leads to dwarfism with impaired cell elongation. Plant Cell 23: 628-640.
69.Wang GX, He QY, Liu F, Cheng ZK, Talbert PB, Jin WW (2011). Characterization of CENH3 proteins and centromere-associated DNA sequences in diploid and allotetraploid Brassica species. Chromosoma 120: 353-365.
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71.Chai CL, Fang J, LiuY. Tong HN, Gong Y, Liu M, Wang YH, Qian Q. Cheng ZK, Chu CC (2011). ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice. Plant Mol. Biol. 75: 211-221.
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