中文关键词:环丁烯酮开环反应喹啉 英文关键词:CyclobutanonesRing opening reactionQuinoline 基金项目:江西省重点研发计划项目（20192BBG70060）、江西省****人才资助计划项目（20192BCB23027）和江西省科学院重点科研项目（2017-YZD2-18）资助 摘要点击次数:529 全文下载次数:0 中文摘要: 在酸催化作用下，成功实现了3-氨基-2-环丁烯酮开环重排一步合成喹啉类化合物，对反应溶剂、催化剂、温度、投料比等影响因素进行了考察，在优化反应条件下催化合成了一系列喹啉类化合物，获得了较好的产率。该合成方法具有反应温度低、产率高以及反应迅速等优点，为喹啉类衍生物的合成建立了一种简单有效的新方法。 英文摘要: A series of quinoline derivatives were successfully obtained through opening-cyclization reaction of 3-amino-2-cyclobutanones in the presence of acid. By screening the reaction solvent, catalyst, temperature, feed ratio and other factors, the optimal reaction conditions were obtained. The method exhibits many advantages such as low temperature, high yield, rapid response and so on, and it establishes a simple and effective new method for the synthesis of quinoline derivatives. 查看全文查看/发表评论下载PDF阅读器 相关附件：版权转让声明书 -->